I recently had a reactive 41 KD Band on the Western Blot test. Does this definitely mean that I have Lyme, or are there other possibilities? There was no other reactive band on the test, and it is the only test that I have had thus far.
Thanks!!
Posted by adamm (Member # 11910) on :
Check out Dr. C's Western Blot explanation. If you have Lyme symptoms in addition to this band, you need to treat.
Posted by METALLlC BLUE (Member # 6628) on :
No it doesn't mean you have Lyme Disease, but it's a very important indication however -- that many ignore -- that Lyme Disease should be pursued with further testing and clinical observation with a Lyme Specialist.
The reason is, if you're running a variety of tests and have a variety of symptoms, and everything is showing up negative, then it only makes sense to pursue Lyme Disease to rule it in or out given what is known about the controversy, poor testing accuracy, as well as a great deal that is unknown about the various strains of the infection.
If a 41kd was seen on a regular laboratory report, such as Quest or Labcorp, then more testing should be performed thru Igenex (in my opinion). A western blot #188 and #189. This test is a better indication. Additionally, a small trial of antibiotics can be run before testing. It doesn't have to be done, but If the infection is present, the dying bacteria will trigger an immune response, leading to higher antibody levels that will show up on the Igenex testing (high probability, not absolutely).
Posted by METALLlC BLUE (Member # 6628) on :
quote:
Icon 1 posted February 13, 2009 11:31 AM Profile for lymestop Send New Private Message Edit/Delete Post Reply With Quote what does it mean when on one test it had a IGM 41 positive and on the next test it had both IGG AND IGM 41 and on the old test a IGG band of 39 is not gone?
Probably nothing right>?? Just curious though?
It mean 41kd is showing up as active as well as a long term or older infection. If 39kd is present on an IGM or IGG, it would immediately peak my interest even further because it is specific to "only" borrelia burdorferi (the cause of traditional Lyme Disease)
When two bands show up together, especially 41 and 39, I would immediately recommend an immediate consult with a Lyme Disease specialist -- again, to rule in, or out the illness. The probability -- if history supports it, with that evidence, that Lyme Disease is more likely than not, to be present.
Posted by sutherngrl (Member # 16270) on :
Thanks Lymestop! This just confirms for me what my LLMD said about band 41.
It is the only band that showed up for me, WB done through Labcorp.
My LLMD considered it very significant for LD.
Posted by METALLlC BLUE (Member # 6628) on :
Lymestop, The coming and going of various bands isn't uncommon during treatment. If you still have IGM 23 and 41 showing up, that of course means treatment should be ongoing and necessarily.
As far as the IGG bands of 39 disappearing, it doesn't mean much, since the IGG 41 indicates indirectly thru the IGM 23 that a borrelia specific infection is still present. 39, 23 -- doesn't matter basically. Even if all the bands disappeared, but you were still symptomatic, it meant treatment should continue. Of course this is assuming your doctor is taking into account the vast array of co-infections and other subtle aspects of metals, detox and such too.
Posted by Dekrator48 (Member # 18239) on :
I agree that you should have an Igenex western blot IgG and IgM, if that's not where your test was done.
Make sure you get a copy of your results and compare them to western blot info on page 7 of:
Even if it says negative, the results can still indicate lyme.
Posted by She R Lock (Member # 18823) on :
Hi Lymestop, My labs are same as you. Started out in July with all three bands of IGM(23,39,41). I'm still positive for bands 23 and 41 both IGM and IGG. I believe I still have an active infection...
Posted by seekhelp (Member # 15067) on :
All docs I've spoken to say everyone has band 41 and it's meaningless. The things written here do not concur with general MD opinions. I was told nearly the entire population shows the 41kDA band.
Posted by Lymetoo (Member # 743) on :
This was mentioned, so I decided to bring the link to you:
The number of people exposed is in the millions. The reason you can't get treated is they have decided that only early disease merits diagnosis and treatment. The bacterium itself is the most bizarre human bacterial pathogen known, and is poorly understood.
They don't know how many people are carrying a permanent relapsing brain infection. you can't get diagnosis or treatment because they have to pretend it doesn't exist and use labels like 'post lyme' and 'CFS' etc. for those who manifest illness.
Look at what Steere did in his 1992 study which is the foundation for the CDC serodiagnostic standard. He and others often look back on this and refer to a 'normal' control, but in fact the control was taken from sick people...MS sufferers, CFS sufferers, in sum, conditions which could have been caused or complicated by late Bb infection. Moreover, he threw in 25 syphilitic patients which constituted 20% of the control. Hoever, syphilis itself has an annual US incidence of 3 per 100,000.
This statistical chicanery, which fudged the result at 41 kDa on Bb blot by many multiples, is significant, because syph serum will cross react at 41 kDa to Bb western blots. It allowed them to 'swift boat' the importance of the reaction to 41 kDa, which is the earliest and most consistent human ab response to Bb infection, being present in all stages as opposed to the rest of the proteins which are variably expressed according to stage, tissue type, even temperature.
Flagellin {41kDa} is necessary for Bb to survive under all conditions, and is constantly expressed, including in late CNS infection. Yet they chose to swift-boat this response.
Why? It's for political and economic reasons. telling the truth about diagnosis and treatment results in mass panic and probable economic collapse/political revolution. it's likely a bioweapon. North American disease is different from European disease...lack of CSF antibodies, for instance.
A much larger range of serum resistance to host species in wild{allows Bb to infect a much wider range of species, important in disease spread and maintenance in wild}. The CDC has found that Bb 31 goes intracellular in CNS cells.
Telling the truth threatens the careers and livelihoods of the very individuals who control this issue and who have actively lied and deceived and otherwise operated a scientific propaganda campaign for the past 15+ years, profitting from the campaign as they went.
Lyme disease, which in the US also perhaps includes other pathogens notably a bioweaponized bartonella, threatens the entire establishment. If late disease was rare, we'd be able to get treatment. Unfortunately, the EIS/CDC,DOD totally screwed this up and tried to make money off of the disease, making profitability their first priority as opposed to protecting the health of americans.
Think about this...Allen Steere wouldn't listen to Polly Murray in early 90's when she reported a big incidence of neuropsychiatric disease in lyme. She had to call Fallon. Now, Fallon has overwhelming evidence of a serious disabling relapsing brain condition which is not easily treated.
Global hypoperfusion on spect/pet ain't normal folks. Don't you think the CDC etc. should be breaking their balls trying to figure it out? Instead, we see nothing at all, only continued attempts to deny illness and obstruct treatment.
Obviously, they know what is going on, and have determined that the best course is to do nothing, to cover up, knowing that in doing so, they are condemning large numbers of people to perpetual diagnostic and treatment hell.
Think about it. It's a horrific scandal and I'm not sure how much longer these *******s can keep control of it."
[ 02-18-2009, 07:56 PM: Message edited by: Lymetoo ]
Posted by disturbedme (Member # 12346) on :
seek - that's because nearly the entire population has lyme. Some LLMDs believe up to 80% of people have lyme unknowingly -- meaning they have lyme and/or co's but are asymptomatic or nearly asymptomatic.
Posted by seekhelp (Member # 15067) on :
80%? Ummmm...I just don't agree. I'll leave it at that. W
Posted by Lymetoo (Member # 743) on :