thread. But maybe this is more appropriate for the
"medical".
Just got my results from Igenex and I don't know
what any of it means.
IGM: 23-25 +, 41++
IGG 31++,34+, 39IND, 41++, 58+
I have an appointment in Hermitage PA with Dr. J
on April 28 and I am not sure what I should do in
meantime.
Any help here greatly appreciated.
I see you all listing these results on your
signatures. I just don't know what they mean.
Thanks in advanced!
Posted by Hoosiers51 (Member # 15759) on :
Looks like Lyme to me. To be CDC positive on the IgM, you need 2 out of 3 specific bands, and 23 and 41 are 2 of those bands (39 is the other one I believe), so that is an IgM positive.
You have some response on your IgG, which can sometimes be an indication that you may respond well to treatment. (not trying to get your hopes up, because it's different for everyone.....)
Even if you tested negative for babesia and bartonella (and don't have any of their symptoms, for that matter), PLEASE don't rule them out, because the testing for those is very inaccuate. I made that mistake, and my first doctor did too, and it cost me.
Sometimes not getting better on just Lyme treatment is a reason by itself to suspect you have the coinfections. (sorry....this may be too much info in the beginning, but my LLMD who was not Dr. J was also out of hermitage PA, and he is the one that missed my coinfections, so that is why I'm warning you).
Just be an informed patient and you will be fine. Good luck!!!! Posted by CheriAnn (Member # 19673) on :
Thanks Hoosiers51. Are there specific treatments
that are different than Lymes treatment for the
co-infections? My contact here in Cinci is
pressing for me to see the other Doc in Hermitage
but he is not covered under my ins. and Dr. J is.
I was feeling uncomfortable but you ma have
helped me there.
Please explain how a positive on my Igm is a good
indicator.
Thanks.
Posted by Lymetoo (Member # 743) on :
WElcome, CheriAnn!! Glad you found us!!! Looks like you have a bit of Lyme there. Sorry you've had to join our lovely club.
The world's best explanation of all those numbers (bands) is right here:
Print it out and read it several times. It will soon begin to make sense! I'll come back and post some info from it, so refresh your screen in a bit.
From the above link, by Dr C of MO:
"On the outer surface of the Lyme bacteria are various proteins. As they have been discovered, they have been assigned letters, such as outer surface proteins A, B, and C.
The following is a brief explanation of the test results. Again, each band is an antigen complexed (bound together) with an antibody made by the immune system, specifically for that antigen (part) of Borrelia burgdorferi.
18: An outer surface protein.
22: Possibly a variant of outer surface protein C.
23-25: Outer surface protein C (osp C).
28: An outer surface protein.
30: Possibly a variant of outer surface protein A.
31: Outer surface protein A (osp A). 34: Outer surface protein B (osp B).
37: Unknown, but it is in the medical literature that it is a borrelia-associated antibody. Other labs consider it significant.
39: Unknown what this antigen is, but based on research at the National Institute of Health (NIH), other Borrelia (such as Borrelia recurrentis that causes relapsing fever), do not even have the genetics to code for the 39 kDa antigen, much less produce it. It is the most specific antibody for borreliosis of all.
41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.
45: Heat shock protein. This helps the bacteria survive fever. The only bacteria in the world that does not have heat shock proteins is Treponema pallidum, the cause of syphilis.
58: Heat shock protein.
66: Heat shock protein. This is the second most common borrelia antibody.
73: Heat shock protein.
83: This is the DNA or genetic material of Borrelia burgdorferi. It is the same thing as the 93, based upon the medical literature. But laboratories vary in assigning significance to the 83 versus the 93.
93: The DNA or genetic material of Borrelia burgdorferi.
In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.
These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93.
This is true regardless of whether it is IgG or IgM.. ----------------------------------
This is from his update written sometime around 2005. Note the bands are different from above.
"The significant antibodies, in my opinion, are the 18, 23-25, 28, 30, 31, 34, 39, 58, 66 and 93."
Posted by CheriAnn (Member # 19673) on :
Thank you , thank you!
Posted by Lymetoo (Member # 743) on :
You're welcome! You have plenty of positive bands, so in my humble non-medical opinion .. little doubt.
Did the IgG and/or IgM come out CDC or Igenex positive?
Posted by CheriAnn (Member # 19673) on :
Yes lab positive on both. and CDC on the IGM. I am
going to go to my regular MD tomorrow, I think. I
wonder if he will Honor these results and prescribe
something?
Posted by Dekrator48 (Member # 18239) on :
CheriAnn,
Don't count on your regular MD knowing anything about lyme (or coinfections).
If he even believes you have it, he will likely tell you that 3 weeks of doxycycline will cure it.
Nothing could be further from the truth.
Only a good LLMD will know how to treat you properly.
![[Smile]](smile.gif)