This is topic Got test results, need help understanding. in forum Medical Questions at LymeNet Flash.


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Posted by Gerifrog (Member # 17990) on :
 
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I was treated with 27 days IV Rocephin last Aug-Sept for neuro Lyme and declared cured, despite continuing

symptoms. My new primary sent me for a lot of bloodwork, including a Lyme test. Quest did it (I can't afford

IGeneX, had to use insurance).


The ELISA was positive at 1.95 - the reference range (or index value)is 0.00-0.90

On the Western Blot I tested:

IgG: Negative
Reactive: 41KD Nonreactive: 18KD, 23KD, 28KD, 30KD, 39KD, 45KD, 58KD, 66KD, 93KD

IgM: Positive
Reactive: 23KD, 41KD Nonreactive: 39KD

There's a comment below it that says:

"Caution must be used in supporting a diagnosis of B.burgdorferi infection when sera are Western Blot IgM

positive and Western Blot IgG negative after the initial 4 week period from onset. Because the likelihood of a

false-positive test result is high for these individuals, a positive IgM test alone is not reccommended for use in

determining active disease in persons with illness of longer than 1 month."


My symptoms are: fatigue, joint pain with mild swelling, headache, sore throat with sporadic laryngitis, memory and

speech problems, comprehension & retention problems, lousy co-ordination and a very poor sense of balance with

gait abnormality. I developed A-fib during my abx treatment. It keeps showing up.

Primary feels it's Lyme and is sending me back to Dr.K, the ID dr who treated me initially. I'm afraid he'll say it's

not Lyme. I don't know what the comment on IgM really means. Does anybody understand this?

Geri
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Posted by Pinelady (Member # 18524) on :
 
The comment sounds like it came directly from the

IDSA and CDC. A lab is not in the business to treat

and I would hang on to that one. I think all

symptoms considered you need treatment. They cannot

have proof of false positives if they have no

proof of chronic Lyme. Or it is all in their

heads. See what I mean. It contradicts everything we know about Lyme.
 
Posted by timaca (Member # 6911) on :
 
EBV can cause a false positive IgM lyme WB. So, have the ID doctor check you for EBV (which can cause the same symptoms as lyme). Also, don't rule out lyme (because of your positive lab tests) but know that other pathogens can be causing your problems.

Timaca
 
Posted by Gerifrog (Member # 17990) on :
 
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What's EBV?

Geri
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Posted by tickssuck (Member # 15388) on :
 
EBV = Epstein Barr Virus. I'm sure if you do a search you'll find lots of info. TS
 
Posted by disturbedme (Member # 12346) on :
 
If you had a positive ELISA, that's Lyme... no doubt about it.
 
Posted by Snailhead (Member # 18091) on :
 
I have a question: how can EBV imitate the lyme antibodies? Do you know which bands specifically can actually be EBV and not lyme, or is it all? For example, if you show a 23-25IGm (which is supposedly lyme specific) can that actually be EBV and NOT lyme???????
 
Posted by timaca (Member # 6911) on :
 
See link:

http://www.springerlink.com/content/631rx51r28577w4

Timaca
 
Posted by Gerifrog (Member # 17990) on :
 
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Timaca - The website says: The page cannot be found.

I did a search for info on EBV - that I know of, I never had mono.

Geri
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Posted by timaca (Member # 6911) on :
 
so weird. Here is the link again
http://www.springerlink.com/content/631rx51r28577w46/
but if it doesn't work, then google search the following words:

"false positive lyme western blot EBV"

Then click on the first article that comes up.

I never had mono either. And I ended up with chronic EBV infection, along with HHV-6, enterovirus and Cpn infection.

If you don't seroconvert to IgG (meaning don't end up with positive bands on the IgG --besides band 41) then it is more likely that you don't have lyme...that it could be a virus.

Best, Timaca
 
Posted by timaca (Member # 6911) on :
 
also, see my post in this thread:

http://flash.lymenet.org/ubb/ultimatebb.php/topic/1/82675

Best, Timaca
 


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