http://www.ncbi.nlm.nih.gov/pubmed/20625435 2010 Jul 6 Interleukin-10 Mediated Autoregulation of Murine B-1 B-Cells and Its Role in Borrelia hermsii Infection B cells are typically characterized as positive regulators of the immune response, primarily by producing antibodies. However, recent studies ...indicate that various subsets of B cells can perform regulatory functions mainly through IL-10 secretion.
Here we discovered that peritoneal B-1 (B-1P) cells produce high levels of IL-10 upon stimulation with several Toll-like receptor (TLR) ligands.
High levels of IL-10 suppressed B-1P cell proliferation and differentiation response to all TLR ligands studied in an autocrine manner in vitro and in vivo.
IL-10 that accumulated in cultures inhibited B-1P cells at second and subsequent cell divisions mainly at the G1/S interphase.
IL-10 inhibits TLR induced B-1P cell activation by blocking the classical NF-kappaB pathway.
Co-stimulation with CD40 or BAFF abrogated the IL-10 inhibitory effect on B-1P cells during TLR stimulation.
Finally, B-1P cells adoptively transferred from the peritoneal cavity of IL-10(-/-) mice showed better clearance of Borrelia hermsii than wild-type B-1P cells.
This study described a novel autoregulatory property of B-1P cells mediated by B-1P cell derived IL-10, which may affect the function of B-1P cells in infection and autoimmunity. ----------------------------------------- More stealth descriptions, but awfully glad to see them working on it. Go Big Blue!