I believe Quest runs a full thrombosis panel but you'd also want to rule out Factor V Leiden which is a genetic condition causing hypercoagulation issues.
Posted by FYRECRACKER (Member # 28568) on :
Perfect! Thanks Posted by Lymetoo (Member # 743) on :
Thinning the blood and hypercoagulation treatment are really two different things.
With hypercoagulation, you need to address the problem of fibrinogen. Aspirin, for example, does nothing to act against fibrinogen.
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Quoting....
Hypercoagulation, or thrombophilia, may be defined as reduced capillary blood flow or a greater tendency than normal for blood to coagulate, or clot. Of approximately 900 borreliosis patients that I have tested, 90 percent have hypercoagulation. Comparatively, only five percent of the general healthy population has hypercoagulation.
Two major aspects of hypercoagulation are infections and hereditary or genetic abnormalities. Chronic infections such as borreliosis, Epstein-Barr virus, cytomegalovirus, human herpes virus 6 and mycoplasma have all been associated with hypercoagulation. These infections appear to be the driving force behind the greater tendency to form blood clots. Infections may elevate levels of fibrinogen, fibrin, thrombin/antithrombin complexes, fragment 1+2, and Factor II (prothrombin) activity which may decrease capillary blood flow..
When you get a cut, the fibrinogen in your blood converts into fibrin, which in turn forms a mesh to create a blood clot to help stop the bleeding. Antithrombin binds to thrombin to form a complex to prevent thrombin from causing blood to clot. Antithrombin protects against too much clotting, when it binds thrombin.
When thrombin is forming a clot it produces fragment 1+2. Prothrombin (Factor II) converts into thrombin, which causes blood to clot. When these coagulation components are high, it indicates that the blood has a greater tendency to clot., and may inhibit blood circulation in capillaries.
Inherited or genetic disorders may also predispose to blood clotting. Some of these hereditary defects include antithrombin activity deficiency, protein C activity deficiency, protein S activity deficiency, Factor II gene mutation, APC resistance (Activated Protein C resistance is also called Factor V Leiden deficiency), elevated lipoprotein(a) or Lp(a), elevated PAI-1 (Plasminogen Activator Inhibiter-1), and elevated homocysteine. Hereditary hypercoagulation test panels are abnormal in 66 percent of borreliosis patients, as opposed to about 25 percent of the general healthy population.
Treatment for hypercoagulation caused by infections is heparin, which is a blood thinner. Typically, heparin is given subcutaneously (under the skin) by injection twice a day in low doses for not more than nine months. It can also be compounded into a troche that dissolves in the mouth, but that is usually more expensive and is often less effective than injections.
Symptoms that improve with heparin are pain, fatigue, cognitive problems and neurological problems. About 80 percent of borreliosis patients feel better with heparin, and it has been a safe treatment so far. One patient did develop bleeding from the rectum, but then a colonoscopy revealed a colon cancer that had not yet spread to the local lymph nodes. In other words, the heparin unmasked a hidden malignancy, so in this case the side effect was a blessing.
Heparin is not only a blood thinner, it is also anti-inflammatory, antiviral, antibacterial, and may even be anti-cancer (unproven). Therapy with heparin usually lowers the level of the coagulation components fibrinogen, fibrin, thrombin/antithrombin complexes, fragment 1+2 and Factor II activity. This is desirable, because elevated levels of these coagulation components can cause decreased capillary blood flow, if they are high enough. Capillaries are microscopic blood vessels that are about eight microns wide. A normal red blood cell, which travels through the capillaries, is about seven microns wide. When elevation of coagulation components occur, they could conceivably attach to the inside surface (endothelial surface) of capillaries, thereby narrowing them. For example, fibrinogen attached to the inside surface could make it harder for a seven-micron-wide red blood cell to squeeze through the narrowed capillary. Reduced blood flow in capillaries would in turn reduce oxygen and nutrients, and reduce removal of toxins from tissues. It stands to reason that if heparin could improve blood flow, antibiotics and hormones would be more effective because they could pass through capillaries easier.
Life is in the blood. Less blood flow means less �life,� and possibly more symptoms and diseases -- perhaps even death.
Hypercoagulation is associated with other chronic diseases, not just borreliosis. It is my opinion that how hypercoagulation is treated will become a paradigm shift in medicine, once further research has been accomplished.
---DR C of MO
Posted by FYRECRACKER (Member # 28568) on :
I've heard of someone who took Heparin injections and all they did for her was make her tummy an icky yellowish color. I mean she said they helped kind of, but sticking yourself on a regular basis and the skin color change, she said it wasn't worth it. The patient is a lyme patient!
Any thoughts? Is Heparin undoubtedly superior to Nattokinase?
Posted by elizzza811 (Member # 24713) on :
I had an ISAC Panel done through Esoterix, which included Fibrinogen Activity, Prothrombin Fragments, and Alpha 2 Antiplasmin - and mine came back abnormal.
I'm actually supposed to start heparin. The only thing delaying my starting it is I'm afraid my recent 24-hour EEG will come back 'normal' and I'll need to have a 48-hour or 72-hour EEG to prove I'm having seizures. And if my sticky blood and Lyme are causing these seizures, I kind of don't want to be on abx and heparin for the retest EEG. So I'm holding off on starting both.
Posted by Lymeorsomething (Member # 16359) on :
I suspect Heparin is more consistently effective but I would try the natural supps before moving to Hep.
Hep is not without its side effects.
Posted by Lymetoo (Member # 743) on :
quote:Originally posted by FYRECRACKER: I've heard of someone who took Heparin injections and all they did for her was make her tummy an icky yellowish color. I mean she said they helped kind of, but sticking yourself on a regular basis and the skin color change, she said it wasn't worth it. The patient is a lyme patient!
Any thoughts? Is Heparin undoubtedly superior to Nattokinase?
--Well.. I was a lyme patient too!
I agree that unless you have the hereditary form, that natural stuff is probably the way to go. I got good results from the heparin, but had to go to the oral form after a month on the shots because of an allergic reaction.
Consider Boluoke (best form of lumbrokinase)
Posted by elizzza811 (Member # 24713) on :
I've tried nattokinase, lumbrokinase, and serrapeptase. The only one I seem to be able to tolerate is the serrapeptase for some reason?
I especially have problems with the lumbrokinase. What could be causing this reaction? The only other ingredients in the capsules are gelatin and maltodextrin.
Posted by FYRECRACKER (Member # 28568) on :
hmm, not sure elizzza, what dosages of Nattokinase were you trying? Just curious..
Yes Lymetoo! Your information was very helpful Glad you keep coming back here.
Posted by Lymetoo (Member # 743) on :
Thanks, Fyre!...
elizza... you may just be sensitive to it... Also maltodextrin sometimes contains gluten.
Posted by kday (Member # 22234) on :
Hmmm... I had test through Quest.
They were pretty comprehensive, and showed that I had a relatively severe DIC (Disseminated Intravascular Coagulation).
I would start at Quest or Labcorp especially if your insurance will cover the tests.
And heparin would probably be easier to tolerate than enzymes, as when the enzymes dissolve the fibrin you can feel like crap. From what I've heard, most people report feeling better on Heparin. Heparin does not directly dissolve fibrin. It prevents it from forming.
I got rid of my coagulation with enzymes in a short amount of time. Never touched heparin, so couldn't tell you if I liked it or not. And heparin is natural.....
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