This is topic Does pulsing make a drug less effective? in forum Medical Questions at LymeNet Flash.


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Posted by bcb1200 (Member # 25745) on :
 
So...I've been pulsing Tindamax for 5 days every other week.

Given all of the hype on the latest research re the benefits of Tindamax vs lyme, I'd like to try to take it continuously for 1-2 months.

My question is...when I start to take it continuously, will Tindamax be less effective since I have already been pulsing it? (Meaning...have I missed out on doing a "sneak attack" on the bugs and now they have already "seen" Tindamax?)
 
Posted by Maradona (Member # 24552) on :
 
You should be OK with continuous tinda.
well if we had normal immunity and we add meds they should clear infection very fast but we do not have.So you did nothing wrong with tinda because i think Tinda kills germs by acumulating toxic waist on them .
 
Posted by TF (Member # 14183) on :
 
I don't see any reason for the Tindamax to be less effective when taken continuously after pulsing.

However you take it, the Tindamax will do what it is good at doing--killing cysts.

My lyme doc had me stop all meds for 1 week, then take amoxi and flagyl continuously. The 1 week stop got the lyme out of the cyst form. Then, the flagyl killed lyme as it tried to go back into the cyst form (to evade the amoxi) for the next 2 months.

That's how I got rid of lyme.

In fact, after 1 month of both of these meds, my doc stopped the amoxi and I took only flagyl for the 2nd month (along with Levaquin to hit bartonella).
 
Posted by t9im (Member # 25489) on :
 
bcb:

JMO but I would recommend against taking Tindamax more than pulsing 3 days a week.

What good is killing the lyme but developing a cancer. It is one of the side effects when taking at an increased dossage.

The pulse opens up the cysts and if your on another drug it take care of the spirochets.
 
Posted by bcb1200 (Member # 25745) on :
 
THanks Tim. Except Dr. B says it must be taken for 3-4 weeks to be effective. So I'd at least like to try and get a month in.
 
Posted by migs (Member # 16496) on :
 
Yes Dr. B has stated a few times in the past couple years that Flagyl (and Tinda, presumably) need at least 2 weeks to be effective. He hasn't stated WHY or why he has come to believe this in recent years, as compared to when he was practicing.

I know many practicing and respected LLMDs do not subscribe to that theory but he is, of course, the guru. I wish he would explain himself better on that point. Most of us would take the cancer risks if we believed it would make a big difference but we need an explanation.
 
Posted by Jamers (Member # 28016) on :
 
My LLMD who has gotten many people well says she does not always use a cyst buster on everyone. Why do some need it and others dont???
 
Posted by TF (Member # 14183) on :
 
Why do some need it and others don't?

My guess is that some people have a very strong immune system (say, they have not been ill with lyme for a long time but just for less than a year). So, when the meds are stopped and the lyme comes out of the cyst form, their immune system is able to kill it on its own.
 
Posted by Fuel1212 (Member # 29312) on :
 
I am only on GSE for breaking down cysts and my immune system is shot (CD57 19)

Wonder if I should be on something other than just Ceftin and Azith?

Interesting
 
Posted by t9im (Member # 25489) on :
 
B:

I believe the reason Tindamax is pulsed is due to its side effects. I just think taking it on a constant basis over a period of time runs other risks.

My daughter pulsed two days a week. One pill a day. She started in Sept and we started to see positive results in mid Dec. but her neuro really imporved by March.

We stopped in April due to auto immune issues plus she developed anorexia. Both of these issues are know side effects of taking Tindamax.

I would think the cancer risk comes more into play if you increase the dosage and length.

Our LLMD did try to increase her dossage in Jan but that is when the auto immune (severe itching reaction) kicked in. She didn't have it for the first 3 months on Tindamax.

I'll post more tomorrow because my overall feeling is once we are done with this I'd like her to take 2 months of tindamax just as a precaution (we did like the drug as her symptoms improved considerably).
 


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