I'm working with my doctor to find alternative products to what is recommended because I am allergic to ingredients in many of the products recommended by Dr. Yasko. It is a long process.
Most helpful supplements for me thus far:
I have the dreaded CBS variant, and it's a double + so I need Molybdenum and Vitamin B12 just to survive all the sulfites, aldehydes, purines, xanthines, etc. (stuff that is processed through the transulfuration enzymes), that are unavoidable in daily living. I also must avoid high levels of B-vitamins (except B12) until I get on the full protocol for the CBS variant...otherwise, the B-vitamins act like neurotoxins to my body.
Magnesium is also a requirement for most of the variants - magnesium is involved in over 300 enzymes in the body, including methylation & related enzymes. A deficiency of magnesium will affect methylation, and doubly so if one has variants in enzymes requiring magnesium to do their job.
Nettle leaves are also on the protocol and I find them helpful for joint pains from Lyme, too.
I've not tried Yucca Root yet (for the CBS variant), but did just get some recently.
Feel free to ask me more questions via email or PM...