This is topic Immunoglobulins/Antibodies - Facts and Thoughts in forum Medical Questions at LymeNet Flash.


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Posted by susank (Member # 22150) on :
 
I again encourage folks to have their total serum levels checked. IGA,IGM, IGG and subclasses.

Read:
http://lymemd.blogspot.com/2008/12/chronic-lyme-and-poor-igg-response.html

http://www.textbookofbacteriology.net/immune.html

Script below fig 5:
....IGG effectively neutralizes bacterial extracellular toxins...
Script below fig 6:
IGA, IGM and IGG ...neutralizing of toxins.....including exotoxins....

Further down:
Function of Antibodies in Host Defense

http://www.ncbi.nlm.nih.gov/pubmed/15006732
http://www.ncbi.nlm.nih.gov/pubmed/12678861

So - defiency in IGG appears to:
Effect the LD western blot,
Makes treatment more difficult,
Makes detoxing more difficult !!??,

I am on IVIG.

Thoughts:
Instead of antibiotics I would prefer to get hyper-immune antibody specific injections to treat Bb and other pathogens.

What has happened to the research on this?
Variations have been successful in the past with serum from humans and horses.

I'll try to find the article in this regard titled "Back to the Future....."

Here: http://www.ncbi.nlm.nih.gov/pubmed/12102547
and related citations listed to the right.
 
Posted by Tracy9 (Member # 7521) on :
 
"Thoughts:
Instead of antibiotics I would prefer to get hyper-immune antibody specific injections to treat Bb and other pathogens."

Thank you. I thought I was the only person in the world who thought it was better to get a human blood product for treatment than a bunch of drugs that damage our organs!!!!
 
Posted by Razzle (Member # 30398) on :
 
Some doctors will give their patients a "vaccine" made from the patient's own blood. This was how my Grandfather was cured of a strange, undiagnosed skin condition, and I've seen/heard about it being done for other diseases as well.

Also, when I was a child, my Mom had a homeopathic practitioner make me a remedy from my hair, to treat the whole "me." I often wonder what would have happened if I had been able to continue with this practitioner...(she passed away when I was still a teen)...
 
Posted by seibertneurolyme (Member # 6416) on :
 
Well the way I see it the 2 predominant LLMD's who use IVIG both happen to be neurologists. And neither of them know much about coinfections which kind of bias their research.

I do not think Dr K in Connecticut who is a professor at Yale has published anything.

Dr Y at NYU has published some things but I have not read the articles. Here is a link.

http://www.lymeneuroborreliosisprogram.org

All the research concerning IVIG and lyme has concentrated on peripheral neuropathy and dysautonomia I think.

Hubby has actually seen both of the docs listed as well as the other neuro who moved from Connecticut to California last year.

Even though he has been sick 11 years now and has a low WBC every time it has been tested hubby's totals and subclasses still are in the normal range. So for him this treatment is not even an option.

From discussions with patients who have done IVIG I have gotten the impression that it is maybe 50% effective at best. And I think one of the major issues is the lack of understanding and/or treatment of coinfections.

This is just my opinion based on hubby's experiences.

Bea Seibert
 


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