This is topic Zinc supplementation AND Nutreval test in forum Medical Questions at LymeNet Flash.


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Posted by Jasmin (Member # 19959) on :
 
I got my son's Nutreval test (Genova Diagnostics) back. He's very low on zinc.

Any advice on buying a supplement?

I also thought I'd share some of the results. I haven't consulted my doctor yet, and I haven't

seen his version of the results which are supposed to have more info... I'd appreciate

any thoughts on these results.

And BTW - his Western Blot had NO bands. The first time he was tested he was only one short

for CDC positive. I know the test is not reliable... but I really wish I could just have

something - ANYTHING - in black and white on paper.

quote:

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--2-HIBA was elevated and is a

metabolite of a gasoline additive. This was just

one decimal

point from not being above the reference range,

and I am guessing it isn't a problem...


--Kynurenic Acid/Quinolinic Acid ratio was low

which is associated with inflammation and overall

neurotoxicity.


--He has low levels of a dietary peptide called

anserine.

"There is no clinical significance for low

anserine."


--Another dietary peptide, carnosine, was

measured to be lower than the reference range.

This is

typically low or absent for individuals who eat

low protein diets... NOT the case in our house!


--The amino acid cystine was elevated, but

without corresponding elevations in other amino

acids.

This is consistent with cystinuria - a genetic

disorder that causes kidney stones. One of the

symptoms is week fingernails, and his fingernails

have crumbled right in the middle many times. It

is also is associated with inflammatory responses

and reduced ability to detoxify if limited

glutathione results.

I'm glad we caught this one because, if he does

have cystinuria maybe he can

prevent stones and never have a problem with it.


--Phenylalanine measured elevated...

This is linked to iron deficiency, subnormal

tissue oxygenation, anemia, pulmonary disorders,

cardiovascular

problems, magnesium deficiency, aluminum excess,

b3 and b1 deficiency, mitochondrial damage,

biopterin insufficiency, adrenocortical

insufficiency, addisons disease and insulin

insufficiency, genetic weakness AND MORE.

Symptoms with mild

moderate hyperphenylalaninuria include fatigue,

headaches, brain fog or mental confusion, nausea

or diarrhea. Artificial sweeteners need to be

avoided. We already do that.


--Ethanolamine was elevated. Magnesium deficiency

is frequently observed to coincide with this, and

could be caused by excess microbial production of

ethanolamine in the intestines and rate-limited

formation of phosphoethanolamine from

ethanolamine. A stool sample is needed to tell

the difference. Other markers for intestinal disbiosis didn't get flagged.


--Phosphoserine is an intermediary metabolite of

serine formation from phosphoglycerate

(glycolysis). It was elevated but serine is not.

Also, phosphoethanolamine is not elevated. This

suggests a rate limitation specific to the

phosphoglycerate-to-serine pathway.

This could be elevated due to a magnesium

deficiency {which he has} or b6 deficiency

{which he has} or coenzyme dysfunction of

pyridoxal 5-phosphate. This elevated

phosphoserine can cause vitamin D dysfunction, or

hormone/steroid imbalances.


--Methionine -amino acid- was elevated. This

implies rate-limited impaired metabolism of this

essential amino acid. This could have

far-reaching consequences and multiple

symptomatology. Magnesium may help.


--Glutamic acid is elevated and dicarboxylic

hyperaminoaciduria is not present.

The known conditions consistent with this are

ingestion of MSG, ingestion of nutritional

supplements containing large amounts of glutamic

acid, gout or pregout, some imbalance or

impairment in purine metabolism, metabolic or

renal acidosis.


--Sarcosine is elevated wich suggests three

possibilities.

1.recent dietary supplementation of

dimethylglycine.

2.Deficiencies of folic acid, THF, b2,

roboflavin. Blah blah cycle blah... can form

formaldehyde and slow down sarcosine's catabolism

while making it somewhat toxic.

3. Genetic weakness which is rare.

Unpublished clinical observations associate some

cases of acquired, mild sarcosinuria with past

exposures to organic chemical solvent and

petrochemicals. It's not known to be toxic,

however, folic acid supplementation is suggested

whenever sarcosine is elevated. He was low on

folic acid.


--Linoleic acid was within reference range but

below the functional physiologic range. Found in

virtually all vegetable oils. Linoleic acid

stimulates normal cellular division and cellular

repair. Inadequate LA may result in eczema-like

skin eruptions, behavioral disturbances,

increased thirst, growth retardation, and

impaired wound healing.


--Arachidonic acid was within the reference

range, but above the functional physiologic

range. AA is

also the main precursor for pro-inflammatory

eicosanoid synthesis. It may contribute to a

feed-forward inflammatory cascade and increased

immune system activation.


--Pentadecanoic acid and/or Tricosanoic acid are

above the reference range. May indicate an

increased need for b12 and biotin,

or may result from an exceptionally high water-soluble fiber diet.


--His lead, antimony, and arsenic were measurable

but not high. This is his second

heavy metals test with the same metals

elevated... but they didn't test for as many

metals this time. He's had two rounds of DMSA so

far.


--And last but not least, his zinc was very low.

He was also low on Thiamin, B6, Folic acid,

magnesium, and lysine and the papers suggest we

supplement them and omega 3's.


Immune dysfunction with impaired T-lymphocyte

activity can be secondary to zinc insufficiency.

In children, delayed growth or stunted growth may

occur. The immune dysfunction was interesting

to me.

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quote:

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Originally posted by Razzle:
Looks to me like methylation is affected. Has he had the Yasko Methylation Panel or MTHFR tested?

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