This is topic Primaquine/Chloroquine experiences? in forum Medical Questions at LymeNet Flash.


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Posted by BoxerMom (Member # 25251) on :
 
Has anyone done this combo for Babesia? Did you take it for more than 14 days?

It's used for the immature liver forms in Malaria. The combo kills both liver and RBC forms.

I need antimalarials that my Babesia hasn't seen yet. Coartem was great, but the 3 day course was too short.

I am tired of taking a bajillion herbs. I want to knock this d@mn infection out!!
 
Posted by Pocono Lyme (Member # 5939) on :
 
A friend and I did the combo at the same time.
She felt better with the Chloroquine and I felt better with the Primaquine.

It did help just doing the 14 days but I felt better yet doing the Primaquine and followed with Coartem.

Primaquine IMHO is key as it's the only drug that I'm aware of that will get the dormant/liver buggers.
 
Posted by BoxerMom (Member # 25251) on :
 
Got my scripts. Starting as soon as labs come back.
 
Posted by BoxerMom (Member # 25251) on :
 
And, yes, will follow with Coartem.
 
Posted by geronimog (Member # 34875) on :
 
I've been diligently battling duncani for the last six months with alinia, cryptolepis, sida acuta, wormwood, flagyl, doxy, proguanil, and clindamycin in all sorts of combinations. Unfortunately all these therapies seem to do is stun the bug, whereby I enjoy symptom relief for a day or so, and then go back to where I was before, seemingly not making any progress. It costs a fair bit of money too.

It used to be I'd get good sustained relief from using only wormwood and garlic. This is before I even knew what I was treating. Years later, though, this no longer works. I attribute this to a weakening of intracellular immunity. I believe this is the real problem in Chronic Lyme. If anybody has any ideas of how to reverse this, I'd love to hear it.

My problem is not with the bug itself, but with the toxin it produces. As such I've never had the typical sweats. The toxin just really aggravates my immune system, causing oxidative stress throughout my body. I think it's a sort of CIRS, as Shoemaker describes it.

So I've been taking chloroquine and primaquine for the past week, and this seems to be more effective than anything I've tried of late. I've been taking 30mg primaquine and just upped my dose of chloroquine to 1g. Now I've never herxed with babs, so I'm wondering if that's what I'm dealing with. I'm experiencing a weird dizziness on the higher dose. It's an odd feeling that I can't really put into words. And I'm also actually getting night and day sweats too. The dizziness does wear off through the day. And my EMF sensitivity is worse.

I'm wondering what other people's babs herxes are like, just to confirm I'm on the right track.
 
Posted by gz (Member # 43818) on :
 
Glad to hear this is having some effect for you!

My babs hasn't changed much since I started treating it, I'm just stunning it with treatment, as you have been. When something is hitting it I just get an increase in babs sx, never had any herxing. So it can be different for everyone, depending on how their babs affects them.

When I hit babs my balance gets messed up, I sweat constantly, drenching at night. I get more fatigue, and increase in tinnitus. The intensity and frequency of my sx is new to me, so hopefully it's a good thing.

If I can't clear it with other methods, I am definitely going to try the chloroquine/primaquine combo and coartem.
 
Posted by geronimog (Member # 34875) on :
 
The thing I'm most concerned about is ototoxicity. The idea of tinnitis scares me.

I took hydroxychloroquine for a couple weeks and for some time after this, whenever I took doxy, I noticed a sort hearing hypersensitivity. This combination has been reported to cause ototoxicity.

I get the same hearing sensitivity with opioids of any kind sp I think I'm probably more susceptible to ototoxicity. I'm feeling it a bit since increasing my dose of chloroquine, which makes me nervous, especially because of its huge half-life and deposits into tissues, but babesia has really messed up my life. So it's a tough call.
 
Posted by Judie (Member # 38323) on :
 
Ugh! I was totally refloxed with primaquine.

It's a quinolone like levaquin and cipro. My LLMD didn't even know this when I asked point blank.

Took it because I trusted the doc and was floxed my 3rd time. God help me, I hope my tendons heal.

I even brought a scientific paper in to show the LLMD the next visit to educate. What a waste. Never went back and still healing from that poison.
 


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