LymeNet Flash: Help interpreting Quest CD-57

This is topic Help interpreting Quest CD-57 in forum Medical Questions at LymeNet Flash.

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Posted by lacyndora (Member # 44278) on :

Hey all,

I received my Quest CD-57 test results today and am stymied.

(I've read through several posts suggesting IGenex is best, and Labcorp is better, but right now, I can only use Quest.)

I copied and pasted exact results below. They certainly don't make it easy to read.

CD57, CD3, CD8, FLOW EZ

CYTOMETRY

CD57+/CD3- OF % LYMPHS 3 (range 1-10%)

CD57+/CD3- OF % WBC 1 (range 1-4%)

CD27+/CD3- ABSOLUTE 58 (range 20-258 cells/uL)

CD57+/CD3-/CD8- OF %

LYMPHS 2 (range 1-5%)

CD57+/CD3-/CD8- OF % WBC 1 (range 1-3%)

CD57+/CD3-/CD8- ABSOLUTE 39 (range 20-114 cells/uL)

CD57+/CD8- OF % LYMPHS 4 (range 1-15%)

CD57+/CD8- OF % WBC 1 (range 1-4%)

CD57+/CD8- ABSOLUTE 78 (range 20-248 cells/uL)

In this thread (http://flash.lymenet.org/ubb/ultimatebb.php/topic/1/126846#000007) @seibertneurolyme mentions that for Quest, the important thing to look at is the "absolute" number, but that threw me off because I see 3 absolutes.

Does anyone know which "absolute" to go by?

Posted by MichaelTampa (Member # 24868) on :

Quest doesn't do the same test. It is not of interest.

Posted by SickSci (Member # 43849) on :

The "CD" stands for "Cluster Determinants", and they're like nametags for different types of cells.

The R. Stricker paper that put CD57 NK1 testing on the map focusses on CD57+/CD8- cells.

So that final Abs value (78 cells/uL) would be your focus, and would be considered "low".

However, the usefullness of this test is really controversial, now. For example, my labcore CD57 result was 15 - scary low and a slam dunk for Lyme by Stricker standards, but my LLMD was not conccerned.