Mitogen-activated protein kinases (MAPK) are protein kinases that are specific to the amino acids serine, threonine, and tyrosine. MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group.
MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines.
They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis (me = cell death).
Wikipedia
Look closely at H4R and Th17 cells (memory)...and the implication in "autoimmune" MS:
Lyme disease-causing borreliae profit specifically from the broadly conserved ***tick histamine release factor (tHRF)***, and from cysteine-rich glycoproteins represented by Salp15 from Ixodes scapularis and Iric-1 from Ixodes ricinus ticks which they recruit to their outer surface protein C (OspC).
PMID:26352137 2015
Me...B6 + CBS (enzyme) -> cysteine -> taurine (lowers cholesterol = autism symptoms) + glutathione + sulfate in the transsulfuration pathway to lower homocysteine versus the "remethylation" pathway to lower homocysteine.
"Tick histamine release factor is critical for Ixodes scapularis engorgement ***and transmission*** of the lyme disease agent.
These findings suggest that blocking tHRF might offer a viable strategy to complement ongoing efforts to develop vaccines to block tick feeding and transmission of tick-borne pathogens."
PMID:21124826 2010
High histamine levels, whatever the cause, increase one's proneness to allergies.