so I would welcome advice from anyone who has already figured this out. thanks!
Posted by sillia (Member # 23994) on :
I think that link describes pretty well how complicated this is -- over methylating as bad as under methylating.
I am hetero for 3 MTRR's. According to my notes this may tend to deplete my B12. I'm also homozygous for MTHFR and have the dreaded CBS +/+. I barely understand any of this, but it does seem like this is one of the factors explaining why I can't get well.
I am just tunneling along, working on this piece by piece as well as I can. I think it is part of my puzzle.
Posted by GretaM (Member # 40917) on :
Hey WP,
I am homozygous for the MTRR mutation also. Aren't we lucky?
I take 15 mg (milligrams, not a typo) of methylcobalamin B12 daily. One tablet under the tongue every morning.
I had to work up to the 15mg.
So far have not noticed an impact in feeling better.
Regards, Greta
Posted by WPinVA (Member # 33581) on :
Thanks Greta! From what I'm reading, it seems better to start the B12 before the methylfolate.
So are you just taking B12?
Right now I'm taking a multiproduct with both methyl B12 and the folate. But I'm thinking I need to stop that and just do the B12 for a while....