While I think disulfiram is very promising and should be considered in any protocol, I promised previously and have been approached by several to finally publish the Goode protocol. It was based on J. Hopkins research on most effective against persisters and research at Northeaster and others on pulsing. Doses aren't shown since these should be adjusted individually, but we used "standard" doses. These were pulsed 2 weeks (all taken at the same time) on with 2 weeks off based on research on pulsing. It's nice to be on meds only 50% time and to give yourself recovery time. 2 weeks is time to disrupt the Lyme growth cycle and two weeks off allows the persisters to start to grow and be killed during next cycle.
Minocycline (against vegetative cells, good brain penetration), Ceftin (close cousin to persister drug identified by J.Hopkins but more readily available), Alinia (biofilm, bartonella, but may have babesia and B.b activity too) and Plaquenil (lower intracellular pH and enhances antibiotic kill and lowers inflammation).
Please share experiences with the protocol here. Best wishes
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