I still think some of us suffered from a sub-clinical immune deficientcy prior to borrelia exposure---there's plenty of proof to back up my assumption
Could very well be a reason why many of us present as auto-immune, while many others do not.
Most healthy immune systems will literally go into *overdrive* fighting the borrelia
Hence, elavated IgG subclasses, and elavated IgM classes, and circulating immune complexes
To the uninformed....that shouts "AUTOIMMUNE"----they never look for an infectious agent that would cause the immune system to mount an attack in this manner---and this is WHAT the immune system is ment to do.
So it gets labeled auto-immune--since neurologist are not trained to recconize the infectious pathology of many neurologicial disease states....and are just too darn lazy to try!!!
Now back to immune deficientcys, or an immune deficient state:
Do notice all the co-factors that many lyme sufferers share.....not just Lyme and other TBD co-infections
Having to deal with molds, funguses, metals, dental infections, staph, strep, mycoplasmas, multiple viral titers that are off the wall, parasites, morgellons like syndrome...I could go on
But I won't...suffice it to say....most immune comptent people don't have the problems dealing with some of the above listed agents that we all ( or most) seem to!!
Lyme is capable of immune supression...no doubt in my allied health mind (PharmD)
But can it cause a permanent aquired mutation?
Immuno-supressed borrelia patients present with a b-cell defect--per common immune status testing measures---bet your glad to hear that! Huh?
For your further reading pleasure, check out the google combo's below
CVID and Toxoplasmosis
CVID and Babesia
CVID and Erlichia
CVID and Bartonella
Lots of immuno-supressive/possiably immune destructive agents that many of us are dealing with
Intialily, the immune system mounts one hell of an attack with regards to the above infectious agents.....this lack of immune responce, or immune recconiztion(SP) later in the disease state, has been linked to those who are late-stage, chronic infection--the worst of us
Does borrelia "Really" invade the immune system?(yes, we have proof positive of that factoid-it enters both the red and white cells and literally destroys the cell---simple explaination...I know!!)) But can it be truly Evasive?(no, or your body would not recconize the pathogen and mount a response in the first place---ever)
Can it cloak it'self--yes, but not be truly evasive--it uses the lipids and clotting factors within us to evade the immune system--so in and of it'self...it doesn't just slink around the immune system unnoticed.
Is that the aquired mutation that triggers CVID and other immune deficientcys???
What's first? The chicken or the Egg?
I'm playing the Devils' advocate here....since I happen to appreciate Zip's posting of abstracts that are both Yey, and nay--with regards to some well loved current lyme beliefs
You gotta look at it from both angles
Many are not getting well--maybe we need to start addressing the immune system more
And not with just supplements and detoxes'