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» LymeNet Flash » Questions and Discussion » Medical Questions » Rhodiola rosea

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Author Topic: Rhodiola rosea
Marnie
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Thanks to Treepatrol...I'm looking at Rhodiola rosea.

Those of you who are already taking this, might be interested in what I found that is one of the many beneficial nutrients (tyrosol) in Rhodiola rosea:

cerevisiae Compound: tyrosol

Synonyms: p-hydroxyphenylethanol

Superclasses: Aromatic Compounds

Empirical Formula: C8H10O2

Molecular Weight: 138.17

Smiles: C(O)Cc1(ccc(O)cc1)

In Pathway Reactions as a Product:

tyrosine degradation :
p-hydroxyphenylacetaldehyde + NADH = tyrosol + NAD

Tyrosol comes FROM tyrosine?!!!

Tyrosine is supposed to -> norepinephrine. Instead is it broken down to provide tyrosol as an antioxidant defense?

Too many dangerous free oxygen radicals reacting with lipids:

Superoxide has an extra electron which it donates to other free radicals making a toxic compound.

This will cause peroxidation and

*nitration of tyrosol hydroxide*

groups on proteins, most dangerous to membrane proteins. Their highest target is the molecule with the lowest degree of oxidation. (e.g. Lipids).

Tyrosine nitration has been shown to be commonly found in a large number of diseases tissues including ALS, artherosclerotic arteries, lungs of septic and ARDS patients, MS, Alzheimer's disease and Parkinson's disease.

In addition, we examined the ***protective effects exerted by tyrosol***, 2-(4-hydroxyphenyl)ethanol, the major phenolic compound present in olive oil.

Caco-2 cell treatment (24 and/or 48 h) with oxidized LDL (0.2 g/L) resulted in cytostatic and cytotoxic effects characterized by a series of morphological and functional alterations: membrane damage, modifications of cytoskeleton network, microtubular disorganization, loss of cell-cell and cell-substrate contacts, cell detachment and cell death.

The oxidized LDL-induced alterations in Caco-2 cells ***were almost completely prevented by tyrosol***

which was added 2 h before and present during the treatments. Our results suggest that some biophenols, such as those contained in olive oil, may counteract the reactive oxygen metabolite-mediated cellular damage and related diseases, by improving in vivo antioxidant defenses.

PMID: 10395586

Too many free radicals!!!

Too few antioxidants and antioxidant enzymes!!!

SOD by Solaray and vitamin E (good kind, taken with a meal) should help...along with good old olive oil.

Better yet...

Halt VLDL release from the liver (stopping the cholesterol pathway) thus prevent VLDL -> LDL.

Halt VLDL release by INactivating the enzyme HMG CoA reductase.

Cholesterol lowering drugs and/or (better) Mg.

Newbies...VLDL is very low density lipoproteins LDL is low density lipoproteins...the "lousy" kind of cholesterol. This is the kind that forms plaques on the blood vessel walls and likely is "sheltering" Bb.

Posts: 9402 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
lymemomtooo
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Marnie, I am just so overwhelmed currently that I can not get this..Are you saying it is a good thing? It was recommended to me that I get it for my daughter and have it on my list..lmt
Posts: 2360 | From SE PA | Registered: Mar 2004  |  IP: Logged | Report this post to a Moderator
Carol in PA
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For those of you interested in this, you can read "The Rhodiola Revolution."

Amazon.com has a good review for this under the hardcover edition. (The softcover is less expensive if you want to buy.)

http://www.amazon.com/gp/product/1579549241/

This herb shows alot of promise to help us with stamina. The Russian military has been doing research on it for years.

Rhodiola helps modulate the HPA axis (hypothyroid - pituitary - adrenal glands).
Lyme Disease disrupts the HPA axis.

Carol

Posts: 6942 | From Lancaster, PA | Registered: Feb 2004  |  IP: Logged | Report this post to a Moderator
Marnie
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HPA axis...

So does the following:

The nutrient...Phosphatidyl Serine (100mg 3x/day) helps to restore that axis...restore the cortisol level if it is too high OR if it is too low! This supplement also usually contains choline and inositol...not surprising!

Get Vitamin E up. Get Vitamin A from your normal one-a-day vitamin-mineral formula.

SOD from Solaray contains all 3 antioxidant enzymes.

There is a product called Alka Max by TriMedica. Run it past your LLMD.

And yes...it certainly looks like this will help, but to get to the ROOT of the problem...

put the brakes on the cholesterol pathway. Halt VLDL release from the liver.

Instead, eat the "good fats" because we have to have SOME cholesterol.

Posts: 9402 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
Marnie
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When things cycle, I always wonder if it is due to the normal life cycle of the cells it is impacting.

Note to others...our cells die and new ones are formed at different times. Some only last one day, others last weeks, others last months.

It depends on which kind of cell...

"It is hypothesized that increase in the concentrations of tyrosol will lead to a decrease in cell number and viability of LLC-PK1 epithelia."

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treepatrol
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Cats out of the bag [Big Grin]
I have been on this for a couple months and it has helped me sleep better take in morning.
I can now sleep when I want I am calmer my wife loves that.
Bp was running high at restarting abx's it was 156/80 and 157/90 since being on it now its been 120/70 128/80 and Iam am really overwieght right now to really over.
Iam thinking clearer and stamina has increased or at least the ability to deal with stressful days better.
So I can say its doing some neat stuff I think even quicker and better thinking out of the box.


ps I put some links about it in NewbieLinks

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
timaca
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I've been on it for a couple of months. I was taking 200 mg twice a day (before breakfast and before lunch) for a total of 400 mg daily. It stabilized my mood very well. I had NO weepiness at all prior to my menstruation. Very level headed and upbeat, which was nice since I've been feeling awful lymewise. It has done NOTHING for my lyme symptoms. Absolutely nothing.

This month, I decided to drop the before lunch dose and see if my mood got a bit worse. And I do appear to be a bit more emotional and sad. That is because my lyme is worse, I'm sure.

I'll stay on the one dose for the rest of the month, then most likely add a 100 or 200 mg tablet before lunch again if indeed my mood is worse on the lower dose.

I asked Dr. Z about it...he said it is a mood stabilizer. That's about it.

My LLMD who rarely suggests herbs, did suggest I try it. His feedback to me was that it helps about half his patients to some degree.

My report is that it helped my mood. That's it.

How much are the rest of you taking?

Timaca

Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005  |  IP: Logged | Report this post to a Moderator
treepatrol
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I forgot to say that this stuff is very sutle in its changes they come on like sneaking in changes {{"mellow"}}.

Dont take anywhere near bedtime will crank your mind up all you will want to do is think.

Iam also on cq10,bcomplex vitamin,magnesium c,magnesium also in pill form,multi vitamin,this may be why my effects are the way they are all working together.

Ill keep ya posted. [hi]

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
timaca
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I ended up adding back in the 200 mg at lunchtime....I was getting too weepy at the lower dosage. Amazing.

I'll be at 400 mg for a month or two, then I may try dropping the dose a bit again.

Timaca

Posts: 2872 | From above 7,000 ft in a pine forest | Registered: Feb 2005  |  IP: Logged | Report this post to a Moderator
GiGi
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Hormones and Adrenals ---

Vitamins that need to be present in enough amounnts - to avoid the bottleneck of the adrenals:

Vitamin C
Vitamin B5
Vitamin B6

Choleserol levels between 180 to 220. If lower than 180, cancer risk goes up; sex drive and joy of life goes down. If it is below, people don't produce their hormones.

Good oils - fish oil, coconut oil, evening primrose, safflower, sunflower, all the omega 6's, 9's, hemp oil. Often Beta TCP from Biotics to make sure that oils are absorbed. Oil can only be absorbed if the bile squirts out bile salts so the oils can be absorbed. If the bile doesn't squirt, oils are not absorbed (stool floats!)

Choice between Rhodiola, Ashwaganda, and Rehmannia. Rhodiola is a great one. In ART testing Ashwaganda comes up most often. Ashwaganda - affects virtually every regulatory process inside the adrenals and up-regulates the whole adrenal function. For those that can't tolerate it, the other two are good picks.

I learned this from Dr. K.'s practice and on myself.

Check with your doctor.

If your cholesterol is higher, check your metal levels.

Take care.

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northstar
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This is an interesting product that contains two of the herbs that Gigi mentioned, plus some. Made by Pure Encapsulations.....and I do not have any ties/whatever.
It was recommended to me 2 years ago, but only took it for a short time.

I bought a new one to have checked by ND, and it tested positive/of benefit.

She also tested that it was to be am, noonish, no later, because of (what I interpreted as) an energizing effect. This was the same thing the first MD said without the AK (applied kin.) testing.

each vegetable capsule contains:
calcium pantothenate (B5) 150 mg.
Panax ginseng extract (root) 150 mg.
(standardized to contain 27-30% total ginsenosides)
Eleutherococcus senticosus extract (root) 100 mg.
(standardized to contain 0.8% eleutheroside E & B)
ashwagandha (Withania somnifera) extract 150 mg.
(standardized to contain 5% withanolides)
Rhodiola rosea extract (root) 50 mg.
(standardized to contain 3% total rosavins and min. 1% salidrosides)
Astragalus membranaceus extract (root) (8:1) 150 mg.
vitamin C (as ascorbyl palmitate) 15 mg.
(hypo-allergenic plant fiber added to complete capsule volume requirement)

Not to be taken by pregnant or lactating women

2-4 capsules per day, in divided doses, between meals.

Phyto-ADR
Vegetarian adrenal support formula


*This vegetarian formula provides wide range herbal and nutritional support for the adrenal glands. Panax ginseng and Eleutherococcus senticosus, or eleuthero, are highly recognized adaptogens, promoting physiological balance and resistance to stress. In part, they help to moderate the production of adrenocorticotrophic hormone (ACTH) and ultimately corticosterone activity. Corticosterone promotes the conversion of amino acids into carbohydrates and glycogen by the liver and stimulates glycogen formation in the tissues, supporting optimal energy reserves. Rhodiola rosea, containing rosavins and salidrosides, also acts to balance hypothalamic- pituitary-adrenal activity. Rhodiola can have a calming effect on the central nervous and supports healthy thyroid, thymus, and adrenal gland function. In particular, rhodiola may moderate the effects of physical and emotional stress. Recently, a double blind cross-over study suggests that rhodiola may help to moderate fatigue under stressful conditions. Astragalus and ashwagandha promote immune support and complement the adaptogenic activity of this formula. Calcium pantothenate, a vitamin B5 derivative, is essential for activating the adrenals. Collectively, these ingredients support the health and activity of the adrenal glands.

Phyto-ADR provides comprehensive support for healthy adrenal function.

REFERENCE: Darbinyan V, et al. Rhodiola rosea in stress induced fatiguea double blind crossover study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000 Oct;7(5):365-371

Northstar

Posts: 1331 | From hither and yonder | Registered: Sep 2005  |  IP: Logged | Report this post to a Moderator
   

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