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» LymeNet Flash » Questions and Discussion » Medical Questions » A slightly different babesia treatment (lower cost)

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Author Topic: A slightly different babesia treatment (lower cost)
david1097
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http://www.ajtmh.org/cgi/reprint/59/4/509.pdf
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Al
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Thanks David ! I've been looking for an alternative treatment for Babesia as I developed severe itching from Mepron, (Poss allergy ?).
Al

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dharmacleaning
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I was just about to say the cost of babesiosis treatment isn't bad - I took clindamyacin and quinine. Had doxy before and after this combo. I don't remember if I ever did zith. Sigh. Maybe.
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treepatrol
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Differential efficacy of drug combinations in the elimination of Babesia infection in humans Combination of drugs Daily dosage (mg) Weeks after treatment Babesia detected in patient by Giemsa-stained blood smears Hamster inoculation


Combination A
Clindamycin plus quinine--
Daily Dosage Clindamycin 1200mg
quinine 1950mg
Weeks 2=positive 4=pos 8=pos 12=pos

Combination B
Azithromycin plus quinine
Daily Dosage Azithromycin 1000mg, Quinine 1950mg
Weeks 2=Negative 4=Neg 8=Neg 12=Neg


A 10-day course of therapy with combination A was given and combination B was administered for another 10 consecutive days two months after initial treatment, and hamsters inoculated with 1 ml of the patient's blood were used to verify the clearance of babesial infection.


Looks like that cured it?
Camp B wins combination B !!!!

Your Link Dave

ABILITY OF AZITHROMYCIN IN COMBINATION WITH QUININE FOR THE ELIMINATION OF BABESIAL INFECTION IN HUMANS


By:

CHIEN-MING SHIH AND CHIH-CHIEN WANG


Department of Parasitology and Tropical Medicine,National Defense Medical Center, Taipei,Taiwan, Republic of China: Department of Pediatrics, Tri-Service General Hospital, Taipei,Taiwan, Republic of China


Quinine

Azithromycin

Atovaquone=Malarone-Mepron

Artesunate
Artemisinin

MathewGoss

Malaria

Babesiosis
Babesia

[ 08. May 2007, 08:02 AM: Message edited by: treepatrol ]

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Do unto others as you would have them do unto you.
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Lymetoo
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I never took mepron either. Cleared it with clindamycin/quinine and artemisinin.

My doctor has stats on HIS patients who have been treated with clindy/Q or mepron/zith. He has about a 5% better result with clindy/Q!!

Thanks for the link, david.

--------------------
--Lymetutu--
Opinions, not medical advice!

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treepatrol
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up

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

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Vermont_Lymie
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Thanks all for the valuable information.

I just got my Quest test results back yesterday --
with a very strong positive for Babesia.

Seven months after starting tx for lyme --
it is good to know.

My llmd prescribed malarone, which I have not yet
started to take. Will pick it up tonight.
Also taking 7g/amoxy/day for lyme.

any of you wonderful experts know how malarone
compares with these other treatments, zith & quinine?

Many thanks!

Yours,
VL [Smile]

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Lymetoo
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Malarone is known as "mepron lite."

--------------------
--Lymetutu--
Opinions, not medical advice!

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CaliforniaLyme
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With tissue stage Babesiosis- which WA1 is but not Microti I believe (could be wrong here- correct me if I am!*) Malarone is a better choice!!! Better tissue penetration thahn Mepron- was a paper on it years back-

--------------------
There is no wealth but life.
-John Ruskin

All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer

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jasonsmith
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quote:
Originally posted by CaliforniaLyme:
With tissue stage Babesiosis- which WA1 is but not Microti I believe (could be wrong here- correct me if I am!*) Malarone is a better choice!!! Better tissue penetration thahn Mepron- was a paper on it years back-

How does that compare to the combo of Azithromycin plus quinine?
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oxygenbabe
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Here's a newer study

http://www.ajtmh.org/cgi/content/abstract/74/3/401

I can't recall-is quinine hard on the system, or was it clindamycin? If its the latter, this might be a good regimen. But how many days? Plus on giemsa smear my babesia doesn't show up but its positive on FISH. So, I don't know how I'd re-test, I guess FISH.

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Boomerang
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I don't know the answers, but hubby is on Clindamycin/quinine combo now. Sounds like his stomach is about to erupt.
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bpeck
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Excellent article...
Read the last page on immunocompromised patients w/Babs.. interesting.

Barb

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treepatrol
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quote:
Originally posted by treepatrol:
Differential efficacy of drug combinations in the elimination of Babesia infection in humans Combination of drugs Daily dosage (mg) Weeks after treatment Babesia detected in patient by Giemsa-stained blood smears Hamster inoculation


Combination A
Clindamycin plus quinine--
Daily Dosage Clindamycin 1200mg
quinine 1950mg
Weeks 2=positive 4=pos 8=pos 12=pos

Combination B
Azithromycin plus quinine
Daily Dosage Azithromycin 1000mg, Quinine 1950mg
Weeks 2=Negative 4=Neg 8=Neg 12=Neg


A 10-day course of therapy with combination A was given and combination B was administered for another 10 consecutive days two months after initial treatment, and hamsters inoculated with 1 ml of the patient's blood were used to verify the clearance of babesial infection.


Looks like that cured it?
Camp B wins combination B !!!!

Your Link Dave

ABILITY OF AZITHROMYCIN IN COMBINATION WITH QUININE FOR THE ELIMINATION OF BABESIAL INFECTION IN HUMANS


By:

CHIEN-MING SHIH AND CHIH-CHIEN WANG


Department of Parasitology and Tropical Medicine,National Defense Medical Center, Taipei,Taiwan, Republic of China: Department of Pediatrics, Tri-Service General Hospital, Taipei,Taiwan, Republic of China


Quinine

Azithromycin

Atovaquone=Malarone-Mepron

Artesunate
Artemisinin

MathewGoss

Malaria

Babesiosis
Babesia

up for everyone.

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

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ElaineC
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Thanks for posting this! Good to know of other options apart from Mepron and Malarone.
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treepatrol
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quote:
Originally posted by ElaineC:
Thanks for posting this! Good to know of other options apart from Mepron and Malarone.

Yep no problem all this stuff is also free for te reading in Newbie links [Big Grin]

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
treepatrol
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upsy

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
   

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