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» LymeNet Flash » Questions and Discussion » Medical Questions » WARNING: cranberry and warfarin = BAD!!

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Author Topic: WARNING: cranberry and warfarin = BAD!!
CaliforniaLyme
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Just so you know, don't drink cranberry juice or take cranberry supplements if you are on this because it can cause fatal uncontrolled bleeding!! Yuck!!!

Just cause a lot of us are on a lot of supplements and a lot of meds- thought I would post a general heads up!!!!!!! Just ran across it and since I had never heard that thought others may not have either-

QUOTE:
Warfarin (also known under the brand names of Coumadin, Jantoven, Marevan, and Waran) is an anticoagulant medication that is administered orally or, very rarely, by injection. It is used for the prophylaxis of thrombosis and embolism in many disorders. Its activity has to be monitored by frequent blood testing for the international normalized ratio (INR). It is named for the Wisconsin Alumni Research Foundation.

Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in licorice, lavender and various other species. Warfarin was originally developed as a rat poison, but it is no longer used for that purpose as modern poisons are much more potent and toxic (e.g. brodifacoum). However, warfarin and contemporary rodenticides belong to the same class of drugs (coumarins) and both decrease blood coagulation by interfering with vitamin K metabolism.

Aston JL, Lodolce AE, Shapiro NL.

Interaction between warfarin and cranberry juice.
Pharmacotherapy. 2006 Sep;26(9):1314-9.
PMID: 16945054

Rindone JP, Murphy TW. Related Articles, Links

Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding.

Am J Ther. 2006 May-Jun;13(3):283-4.
PMID: 16772772


Niklasson A, Andren L. Related Articles, Links

Interaction between Waran and cranberry juice

Lakartidningen. 2006 Mar 15-21;103(11):853-4. Swedish. No abstract available.
PMID: 16613116

Grenier J, Fradette C, Morelli G, Merritt GJ, Vranderick M, Ducharme MP. Related Articles

Sylvan L, Justice NP. Related Articles, Links

Possible interaction between warfarin and cranberry juice.

Am Fam Physician. 2005 Sep 15;72(6):1000; author reply 1000. No abstract available.
PMID: 16190498



Adverse drug reactions in Canada.
Can Fam Physician. 2004 Oct;50:1417-8. English, French. No abstract available.
PMID: 15526880

Isele H. Related Articles, Links

Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?

MMW Fortschr Med. 2004 Mar 11;146(11):13. German. No abstract available.
PMID: 15152759

12: Grant P. Related Articles, Links

Warfarin and cranberry juice: an interaction?

J Heart Valve Dis. 2004 Jan;13(1):25-6.
PMID: 14765835


Suvarna R, Pirmohamed M, Henderson L. Related Articles, Links

Possible interaction between warfarin and cranberry juice.
BMJ. 2003 Dec 20;327(7429):1454. No abstract available.
PMID: 14684645

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Posts: 5639 | From Aptos CA USA | Registered: Apr 2005  |  IP: Logged | Report this post to a Moderator
sizzled
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Interesting info!
Posts: 4258 | From over there | Registered: Jul 2001  |  IP: Logged | Report this post to a Moderator
pq
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Marnie
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Up.

Odd that so many abstracts are unavailable.

Posts: 9402 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
klutzo
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Wow! [Eek!] My husband is on Warfarin and we don't drink cranberry juice, but we do eat whole cranberry sauce, all the time. Do you know if that would count as being as bad? Juice is much more concentrated,and he doesn't eat a lot of the sauce, but this is pretty scary.

Klutzo

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Virginia of Yore
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Thanks for posting this!
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pq
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