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» LymeNet Flash » Questions and Discussion » Medical Questions » This is the one in Humans expression!! Vaccine 2007 OspC

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Author Topic: This is the one in Humans expression!! Vaccine 2007 OspC
treepatrol
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Vaccine. 2007;25(3):466-80(ISSN: 0264-410X Earnhart CG; Buckles EL; Marconi RT Department of Microbiology and Immunology,Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678, USA.


Lyme disease is the most common arthropod-borne disease in North America and Europe. At present, there is no commercially available vaccine for use in humans. Outer surface protein C (OspC) has antigenic and expression characteristics that make it an attractive vaccine candidate; however, sequence heterogeneity has impeded its use as a vaccinogen. Sequence analyses have identified 21 well defined OspC phyletic groups or "types" (designated A-U). In this report we have mapped the linear epitopes presented by OspC types B, K, and D during human and murine infection and exploited these epitopes (along with the previously identified type A OspC linear epitopes) in the development of a recombinant, tetravalent, chimeric vaccinogen. The construct was found to be highly immunogenic in mice and the induced antibodies surface labeled in vitro cultivated spirochetes.


Importantly, vaccination induced complement-dependent bactericidal antibodies against strains expressing each of the OspC types that were incorporated into the construct. These results suggest that an effective and broadly protective polyvalent OspC-based Lyme disease vaccine can be produced as a recombinant, chimeric protein.

[ 03. May 2007, 07:21 AM: Message edited by: treepatrol ]

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treepatrol
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yoooooohhhhhhooooooooooooooo

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treepatrol
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up

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Truthfinder
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But just the same.... who would volunteer to be a guinea pig to test it?

Would you, Tree (assuming there were no other barriers like already having Lyme)? [confused]

Tracy

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Tracy
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treepatrol
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Yes I would as Long as they are using the right peptides. This is OspC the one that all warm blooded recognize

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lou
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Hope they will be checking it to make sure it does not cause the same kind of problems that the OspA vaccine (LymeRix) caused.
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