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» LymeNet Flash » Questions and Discussion » Medical Questions » Resveratrol abstract

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Author Topic: Resveratrol abstract
Vermont_Lymie
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Abstract: Neurochemistry International 2008 Nov 8. [Epub ahead of print]

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.

Karuppagounder SS, Pinto JT, Xu H, Chen LH, Beal MF, Gibson GE.

Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Ave., White Plains, NY 10605, United States.

Abstract

Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses a wide range of biological effects.

Since resveratrol's properties seem ideal for treating neurodegenerative diseases, its ability to diminish amyloid plaques was tested.

Mice were fed clinically feasible dosages of resveratrol for forty-five days.

Neither resveratrol nor its conjugated metabolites were detectable in brain.

Nevertheless, resveratrol diminished plaque formation in a region specific manner.

The largest reductions in the percent area occupied by plaques were observed in medial cortex (-48%), striatum (-89%) and hypothalamus (-90%).

The changes occurred without detectable activation of SIRT-1 or alterations in APP processing.

However, brain glutathione declined 21% and brain cysteine increased 54%.

The increased cysteine and decreased glutathione may be linked to the diminished plaque formation.

This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against β- amyloid induced neuronal damage.

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gemofnj
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Hi Vermont,

I did a litte research on reseratrol, and it seems to be a very good antioxidant.

One site claimed one dose can give the amount of antioxidants in 170 glasses of red wine.

I was going to look into the different brands and figure out which one would be best.

My dad is almost 92 and he is sharp as a tack. His brother on the other hand died of dementia, so it runs in the family.

I would rather die of something else other than alzheimers.. its terrible! [Eek!] [Eek!]

Posts: 1127 | From atlantic city, nj | Registered: May 2008  |  IP: Logged | Report this post to a Moderator
Vermont_Lymie
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Hi Gem,

When I started treating lyme a couple of years back, I was taking Source Natural's brand of Resveratrol, which is reasonably priced.

It is the brand recommended by Buhner (author of "Healing Lyme"), who recommends resveratrol and andrographis for lyme tx, along with some other herbs.

I took this resveratrol for the first year of treatment as a supplement to my main tx; high-dose abx; and I think it helped, along with the andrographis.

Buhner's book is well researched, and I think his suggestions are some of the best of any alternative approach to dealing with tick-borne diseases.

After two plus years of tx, I know the strongest things that have aided my recovery are taking abx, multiple and prolonged. I still like the buhner herbs as a supplement and take andrographis and resveratrol occassionally.

Dementia is scary; I had a cousin who died of it, though given her outdoor exposures in lyme-endemic areas, I wonder if it was really lyme or not.

And the standard caveat -- I am not a doctor, and have no financial ties to anyone/thing mentioned above!

Hope that helps.

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Pinelady
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Be careful of the soybeans though. Some years back. 1980's they were genetically crossed with Brazil Nuts for reasons of increasing the nutritional values to feed the masses. Now I suspect for all of us with increased hypersensitivity to allergens there could be cause for alarm in ingesting soy bean products. It has been proven in medical literature that people that are allergic to nuts are equally allergic to the genetic crossed soybeans.

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

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