Topic: Berberine shortened, info. added and linked
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Do NOT add this to your "protocol" without first discussing it with your doctor!!!
Berberine�the benefits.
NOTE�in many abstracts berberine is indicated to have a very positive effect, but the abstracts don�t usually IDENTIFY which FORM of berberine was used i.e, berberine chloride or berberine sulfate?
We need to know which form to use and at what doses and what timing (likely 3 times per day).
Hopefully Bb will not �spit it out� (efflux pump = MDR- multidrug resistant pump). If so, we may need to add an efflux inhibitor.
Now the many ways berberine works and the diseases it impacts (from my many files):
16. Berberine lowers the retinOl binding protein 4�which would (theroretically) expose Bb�s rhodopsin � if Bb is photosynthetic - (which binds to retinOl) to oxidative stress.When retinol binding protein 4 (RBP4) - a ***cytokine ***secreted by fat cells - is up, a glucose transporter protein called GLUT4 is down. Berberine helps restore GLUT4.
23. Berberine activates AMPK and AMPK activates catabolic pathways to generate ATP. Phosphofructokinase (PFK) is inhibited by high concentrations of one of its substrates, ATP. Bb is PFK dependent (general knowledge). AMPK in macrophages:
38. Inhibits PTP1B (enzyme- Tyrosine-protein phosphatase non-receptor type 1) � negative regulator of the insulin pathway. It mimics insulin action. (Light is absorbed by rhodopsin which is bleached and activates PTP1B which Berberine inhibits.)
40. Berberine inhibits liver gluconeogenesis. Lactate from glucose fermentation + H -> lactic acid + alanine -> glucose (in the liver). To compensate if that pathway is inhibited and to maintain glucose levels, the kidneys do this: lactate +H -> lactic acid + glutamine (which cancer cells love) -> glucose. Thus the levels of glutamine drop and the alanine is free�d up for use. Glutamine is our most abundant amino acid, alanine is second.
Berberine might decrease how quickly the liver breaks down some medications. Taking berberine along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking berberine, talk to your healthcare provider if you are taking any medications that are changed by the liver.
NOT TO BE TAKEN DURING PREGNANCY. May stimulate labor. Likely no need as lyme symptoms are downregulated during pregnancy perhaps because mannose binding lectin is upregulated.
sammy
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Member # 13952
posted
For all those taking GSE, I found that berberine can negatively interact with GSE. I did not keep the link because I was disappointed. If I have time, I'll try to find it again.
Posts: 5237 | From here | Registered: Nov 2007
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Keebler
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- Marnie,
Thanks so much for this streamlined annotated bibliography. Very nice. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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Keebler
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- Adding to those above (and with TCM meaning Traditional Chinese Medicine): ----------------------------
PHELLODENDRON � from One Earth Herbal Sourcebook (Tillotson, et.al.)
Excerpts:
. . . �Huang� means yellow in Chinese, and phellodendron bark is one of the "three huangs," or bright yellow plants used for treating inflammation and infection (the other two are scute root and coptis rhizome).
The yellow color comes from an alkaloid called berberine, a substance that is slightly-to-mildly toxic in pure form, which is why it is not recommended for use in pregnancy.
Berberine is also found in goldenseal root (Hydrastis canadensis), Oregon grape root(Mahonia aquifolium) and several other well-known herbs.
The clinical differentiation among these three yellow TCM plants serves as an excellent argument against concentrating on a single chemical or group of chemical compounds in a plant.
While valuable at times, this practice can limit our perspective. It is tempting to make a general statement that all plants containing berberine are basically the same in their actions.
However, TCM doctors tell us that scute root is most useful for treating inflammation in the lungs and upper respiratory tract, including allergies.
On the other hand, coptis rhizome is useful for treating upper body inflammation, but not allergy. Rather, it is most effective when there is strong heat in the heart and other organs, high fever, and sore throat.
Phellodendron bark is more appropriate for treating inflammation in the lower parts of the body and for heat cause by deficiency. . . .
The berberine alkaloid can be found in the roots, rhizomes, stem, and bark of the plants. Berberine-containing plants are used medicinally in many traditional medical systems, including Ayurvedic herbal and Chinese herbal medicine.
Coptis chinensis rhizome -- Golden Thread -- Huang Lian -- Intense yellow color most likely due to high content of berberine, which is very bitter in taste.
. . . some PubMed links include:
. . . Effect of berberine on regression of pressure-overload induced cardiac hypertrophy in rats.
Excerpted from �Nutrition & Healing� newsletter, Vol. 17, Issue 9, November 2010 -
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Catgirl
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posted
Thanks for providing all of this Marnie!
Sammy is this it? ..."Berberine may decrease the efficacy of tetracycline, thus, in theory, berberine may decrease the efficacy of herbs with antibacterial activity...
This link has lots of warnings on it (regarding mixing it with other things), for example it may decrease the metabolism of vitamin B, so concurrent use of berb and B should be avoided.
-------------------- --Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together). Posts: 5418 | From earth | Registered: Mar 2011
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Marnie
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posted
I am currently trying GlycoX 250 at *dinnertime* (we eat late)...once a day...going slowly to see how I react to it.
No problems. Stools a little more frequent and softer.
It maybe impacting my ability to fall asleep (somewhat) because I can't stop "thinking"...brain has the glucose it needs, perhaps?
I counter with ONE Niquil or Unisom sleep TAB if nec.
But I don't have lyme and I'm not on any meds.
I've read it does NOT impact the beneficial bacteria.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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nonna05
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Does anybody have a LLMD treating /giving this as part of their protocol??
Marnie,,No Lyme???? Do you have co-infections?? were treated and well or just never had it??
It's amazing what medical info you have upstairs Posts: 2563 | From Denver,CO | Registered: Aug 2011
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
My sis has lyme and coming from a med. background (retired OB RN) I didn't understand why abxs (all) and a ton of supps didn't cure her.
So I began to research and research and...
Nonstop 12 years now.
I have to accept the fact that it is everyone's choice which route to go...alternative (Rife, infrared, nutrition) or traditional.
I'm dedicated to finding the safest and most affordable cure for lyme patients. Safety first.
There have been (and maybe currently are) other persons on this board who have a medical background too. We have had a dentist here and a vet.
I'm hoping there maybe someone else reading who has a medical background and can take my links and run with the information.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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posted
Dr.Buhner's new book discusses berberine but not the specific type to take. He just suggests berberine for specific issues.
-------------------- Faithful
Just sharing my experience, I am not a doctor. Posts: 2682 | From Colorado | Registered: Oct 2009
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lymeinhell
Frequent Contributor (1K+ posts)
Member # 4622
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My LLMD gave me a Burbur (NutraMedix) tincture to use. Would it have the same benefits?
Oddly enough, a few days after I started it, I started seeing dead parasites in the toilet.
I'm not on abx, and haven't been for almost 7 years now. But I do take a beta blocker and Zyrtec. Should I be concerned?
-------------------- Julie _ _ ___ _ _ lymeinhell
Blessed are those who expect nothing, for they shall not be disappointed. Posts: 2258 | From a better place than I was 11 yrs ago | Registered: Sep 2003
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Run this by a couple of pharmacists (more than one):
Ask him/her if berberine (name the one you are interested in ...berberine sulfate or berberine chloride) reacts with your (name of) beta blocker and if the berberine (you selected) reacts with Zyrtec.
If necessary, you can call the drug companies that make the above and ask them.
I don't know which berberine maybe the best form and I don't know if Bb will/can "export" it.
What I have found (so far):
Berberine (Barberry) (Berberis aquifolium)
Berberine may increase the antihypertensive action of antihypertensives; use cautiously. (LSR)
Berberine may increase the effect of calcium channel blockers. (LSR)
lymeinhell
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posted
Thanks so much. I will do that.
-------------------- Julie _ _ ___ _ _ lymeinhell
Blessed are those who expect nothing, for they shall not be disappointed. Posts: 2258 | From a better place than I was 11 yrs ago | Registered: Sep 2003
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