LymeNet Home LymeNet Home Page LymeNet Flash Discussion LymeNet Support Group Database LymeNet Literature Library LymeNet Legal Resources LymeNet Medical & Scientific Abstract Database LymeNet Newsletter Home Page LymeNet Recommended Books LymeNet Tick Pictures Search The LymeNet Site LymeNet Links LymeNet Frequently Asked Questions About The Lyme Disease Network LymeNet Menu

LymeNet on Facebook

LymeNet on Twitter




The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

LymeNet Flash Discussion
Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive


The Lyme Disease Network is a non-profit organization funded by individual donations.

LymeNet Flash Post New Topic  New Poll  Post A Reply
my profile | directory login | register | search | faq | forum home

  next oldest topic   next newest topic
» LymeNet Flash » Questions and Discussion » General Support » Parasitic Spirochetes

 - UBBFriend: Email this page to someone!    
Author Topic: Parasitic Spirochetes
treepatrol
Honored Contributor (10K+ posts)
Member # 4117

Icon 1 posted      Profile for treepatrol     Send New Private Message       Edit/Delete Post   Reply With Quote 
THE HONG KONG UNIVERSITY OF SCIENCE & TECHNOLOGY
Biology Departmental Seminar


Unique Physiological and Pathogenic Features of Leptospira interrogans Revealed by Whole Genome Sequencing

by

Guoping ZHAO, Ph.D.
Professor and Executive Director
Chinese National Human Genome Center at Shanghai (CHGCS)


Abstract

Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as hemorrhage and jaundice. In more severe cases, massive pulmonary hemorrhages, including fatal sudden haemoptysis, may occur. Here we report the complete genomic sequence of a representative virulent serovar type strain Lai of Leptospira interrogans serogroup Icterohaemorrhagiae consisting of a 4.33-megabase large chromosome (GB: AE010300) and a 359-kilobase small chromosome GB: AE010301 , with a total of 4,769 predicted genes. In terms of the genetic determinants of physiological characteristics, the facultatively parasitic L. interrogans differs extensively from two other strictly parasitic pathogenic spirochetes, Treponema pallidum and Borrelia burgdorferi, though similarities exist in the genes that govern their unique morphological features. A comprehensive analysis of the L. interrogans genes for chemotaxis/motility and LPS synthesis provides a basis for in depth studies of virulence and pathogenesis. The discovery of a series of genes possibly related to adhesion, invasion, and the hematological changes that characterize leptospirosis has provided clues about how an environmental organism might evolve into an important human pathogen.

Abstract

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
treepatrol
Honored Contributor (10K+ posts)
Member # 4117

Icon 1 posted      Profile for treepatrol     Send New Private Message       Edit/Delete Post   Reply With Quote 
Lastly, a recently developed animal model now allows us to generate large numbers of mammalian host-adapted spirochetes for further molecular studies. We are utilizing this novel animal model in conjunction with several differentially expressed, plasmid-encoded proteins to help elucidate the signal(s) that result in B. burgdorferi "switching" to the host-adapted phenotype. The overall goal of this research is to gain a better understanding of the dynamics of the host-adaptation process which appears to be an important part of the parasitic strategy of the Lyme disease spirochete.

abstract

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
   

Quick Reply
Message:

HTML is not enabled.
UBB Code is enabled.

Instant Graemlins
   


Post New Topic  New Poll  Post A Reply Close Topic   Feature Topic   Move Topic   Delete Topic next oldest topic   next newest topic
 - Printer-friendly view of this topic
Hop To:


Contact Us | LymeNet home page | Privacy Statement

Powered by UBB.classic™ 6.7.3


The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA


| Flash Discussion | Support Groups | On-Line Library
Legal Resources | Medical Abstracts | Newsletter | Books
Pictures | Site Search | Links | Help/Questions
About LymeNet | Contact Us

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to Terms and Conditions.