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» LymeNet Flash » Questions and Discussion » Medical Questions » What's your explanation of brain fog?

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Author Topic: What's your explanation of brain fog?
cigi
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I'm confused (why not?) I feel I'm intellect ok (not Einstein,but can add...work, still play my guitar, converse like myself...) but am on an emotional vacation. I look in the mirror, don't identify myself, take care of my dad, son, sisters that need help, and am doing regular tasks, without identity. I guess the meds I'm on aren't making me panic about the "missing me", but does anyone feel like this. On 2g rocephin now. In my regular frame of mind, I'd be insane about this, but I guess lexapro and xanax are taking care of that. On flagyl, I had absolutely no short term memory, phone #, lost car, at work had to ask the same woman 3 times what kind of product she wanted...Spect says global hypoperfusion and heterogenous...

What's your brain fog and intellect/emotional status? Anyone cursed with the same? Did that happen and you got yourself back with treatment? I know everyone's different, but knowing some have gotten better would make a difference. June 3 + in the IGM and 7+ in the IGG from Igenex. November low positive from Stony Brook.

Appreciate all info.

Thanks much -

Cigi


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Lymetoo
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I would say the lexapro and xanax are causing the "missing me"...just my opinion. I define brain fog as that state in which you can't concentrate, think clearly, or remember simple things. That's not an all inclusive list!

------------------
oops!
Lymetutu


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david1097
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I think that the exact deficit that you see is depedant on which part of the brain is affected. I is different for each person (sort of like MS lesions) It may be a result of lower blood flow, local metabolism or maybe something to do with the bacteria and what it releases, or mre Probably all these combined. The global hypo perfusion is liely descriptive of of a large number of low perfusion area scattered throughout the brian as opposed to the whole brain showing low flow. In fact if the whole bran had low flow, it would be difficult to quantify the fact the it was hypoperfuse. Its that some of these spots of low perfusion are in the spots that cotrol those thought processes. At least thats my thought. Maybe the member durameter can give more info on this, he/she is very conversant on the function of the brain.

I had a bout where could not easily identify my own name. It eventuallyt cleared up with treatment.

All of this stuff came and comes in wave for me. Every two weeks it is worse, then it clears up and was better than before. Prior to treatment the two week cycles would still appear but after each cycle I cleared up a bit but was always worse than I had been before the cycle peak occured.
Thus the trend was roller coaster like but the long term trend was down with no treatment and up wth treatment.

The first round of flagyl made things worse (again in this cycle pattern) but in the end helped a lot. The second round had some what effect.


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Areneli
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Lyme can influence our thinking with two different mechanisms:
1. Bb biotoxin produced in bacteria anywhere in the body but not necessarily in the brain (treatment with Questran and any oral antibiotic for Lyme should be sufficient)
2. Bb growing right inside of the brain (treatment with antibiotics penetrating BBB such as Rocephin i.v. or Minocycline p.o.)
Sometimes it is hard to tell with which mechanism we deal with at the moment, or perhaps both.

[This message has been edited by Areneli (edited 12 February 2005).]


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3greatkids
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Yes,I have been cursed with the fog,my 1st Dr. dismissed it and blamed it on my taking pain meds.

I have been lost,developed severe ADD,could not read more than a few sentences from a novel,forgotten where I was going(hung up my keys).I have been a zombie and stared at the telly just to feel apart of the world.

I have slowly come out of that,the Mino and BBB abx have helped,rough though and I know there is damage there.

I am fortunate to feel the brain working again.I am able to read novels once again and my love of writing letters to friends and loved ones has returned.

Yes, the fog is scary,horrible and a true test of patience.Time and treatment will bring one out of it.Muti tasking will come back but until then Simple Pleasures and one step at a time!Do only what is Most important and keep a list at all times.Pencil and paper will be your best friend,write down reminders as soon as they enter your mind.

This is wild,when I firt began Flagyl,I felt like I was going to crawl out of my skin.I needed Ativan to offset it.Now the Flagyl seems to give me the jump start I need and I do not get the edge it once gave me.Guess it has been working.

Hang in there and give it time,you will come out of the dreaded fog and be able to feel normal again.Good luck.


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TheCrimeOfLyme
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inflammation, hypoprofusion ( i know I spelled that wrong- Im blaming brain fog

the disease itself, vaso constriction, killing the infection.

Yeast can do it too!

There is too many to mention that can cause it, Im sure one day they will find out for sure what does.

I can't limit it down to two specific things that cause it though.

Mine went away on 4000 mg of amoxy daily. I still get it from time to time.


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Areneli
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I may agree that there are also other ways, but believe that the other reasons such as yeasts or lack of vitamins would rather cause minor fogginess but a lot of fatigue.
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lymeHerx001
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sugar feeds the bacteria and then they release toxins which make brain fog.

Acetaldehyde is one of them.
The same toxin that produces a hangover.

I ate lots of sugar in the past 3 days and today I feel confused as all hell.
LOST

[This message has been edited by lymeHerx001 (edited 12 February 2005).]


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duramater
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Can anyone point me to data/papers/references indicating that Borrelia bacteria produces toxins?

Many thanks
~DM


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HaplyCarlessdave
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Sorry for the extra clutter, but I feel I must leave your post on here, since you answered much of your question (described "brain fog") yourself.
As to whether ot gets better, in a word yes. In many words:
Well. it gets alot better, but many people experience some irreversible damage from lyme etc.that's definitely noticeable.
In my case, I seem to have gotten back nearly to where I was, but I'm definitely not quite "all there" yet. I say "yet" because I see signs occasionally that I'm still improving. But my scenario is extremely complex. I have been missing some brain function in specific area, but not at all across the board, due to my being a head injury survivor since long before I had Lyme. It is an extremely frustrating disability. And I got lyme with babs and ehrlichia on top of that, which was made much more serious because I also lost my spleen from the same original traumatic occurence that gave me the head injury. The neuro effecvts of lyme were still quite noticeable, though. "Brain fog describes one aspect of these effects.
But I still played piano- I was playing quite a bit of jazz the year after I got lyme. But it was mostly tunes I've been doing for years, that are more or less "fried in". And the way music is for me, I get very good at ignoring pain when I hear or play music. (I needed lots of help carrying the equipment, though!). So I imagine playing guitar helps you stand the pain, too. But learning and writing new stuff may be slower.
It's the long-term distracting nature of the lyme that makes it SO hard-- yeah, with enough pain killers (though I would avoid ...'celebrex'.... like the plague, I will warn you!) you can muddle through the night, make isolated replies to comments, announce tunes, etc. But "one's best" kind of like goes on vacation when you have lyme, etc- sustained concentration is impossible.
As I said, though it will get MUCH better. Do you have babesia, too?
quote:
Originally posted by cigi:
I'm confused (why not?) I feel I'm intellect ok (not Einstein,but can add...work, still play my guitar, converse like myself...) but am on an emotional vacation. I look in the mirror, don't identify myself, take care of my dad, son, sisters that need help, and am doing regular tasks, without identity. I guess the meds I'm on aren't making me panic about the "missing me", but does anyone feel like this. On 2g rocephin now. In my regular frame of mind, I'd be insane about this, but I guess lexapro and xanax are taking care of that. On flagyl, I had absolutely no short term memory, phone #, lost car, at work had to ask the same woman 3 times what kind of product she wanted...

Spect says global hypoperfusion and heterogenous...

What's your brain fog and intellect/emotional status? Anyone cursed with the same? Did that happen and you got yourself back with treatment? I know everyone's different, but knowing some have gotten better would make a difference. June 3 + in the IGM and 7+ in the IGG from Igenex. November low positive from Stony Brook.

Appreciate all info.

Thanks much -

Cigi



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HaplyCarlessdave
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I thought I better add the "caveat":
Don't be in a hurry, though-- I was treated for over 2 years! These are some nasty "bugs"!
DS

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cigi
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My doc wants to treat me for babesia (mepron) also and also for bartonella -I'm just having such a hard time on the rocephin. WBC constantly dropping, sodium...I tested positive in the IGG bartonella last year, then it went back in range. She said bartonella peaks - that's when I tested positive.

Who knows with this disease. I just know at one time I had confidence, look in the mirror, slept sound, recognized myself and now, like everyone, has to take five minutes at a time because you don't know where this is going next.

Thanks much for your replies.
God bless -

Cigi


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minoucat
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DM, I've been looking this up too. I found the Bb neurotoxin issue a very confusing one. I don't think I've seen anything that definitively links Bb with neurotoxins; rather, there's evidence (gene sequences; similarities with other toxin-producing pathogens; symptoms, etc.) that Bb could/does produce it.

Some articles associate tick-borne disease (especially tick paralysis) with neurotoxins, without specifying Bb as the origin of the neurotoxin.

I think there is a very broad use on this board of the word "neurotoxin", ranging from a specific family of lipoproteins to anything that has a negative impact on cognitive/emotional function. Which is fine by me, since I've experienced brainfog that I think was caused by everything from yeast to hypoglycemia to painmeds to LD/Co. But it would help to know what is what, when you're trying to eliminate the culprit...

Here are 3 abstracts, pretty representative of what I found, publications about it.

Pub Med
Przegl Epidemiol. 2002;56 Suppl 1:57-67. Related Articles, Links

[New aspects of the pathogenesis of lyme disease]

[Article in Polish]

Zajkowska JM, Hermanowska-Szpakowicz T.

Klinika Chorob Zakaznych i Neuroinfekcji AM w Bialymstoku.

Morphological changes of B. burgdorferi as well as changes in expression of surface proteins caused by environmental determinants are essential in pathogenesis of Lyme disease.

Cysts, spherical form (spheroplasts, L-form) and "blebs" (gemmae) can be responsible for long lasting antigenic stimulation, signs of chronic borreliosis, and even probably connected with MS and Alzheimer disease.

Mechanisms to avoid elimination and persistence in the host include: expression of low heterogenic Osp A, B replaced by polymorphic in sequence and antigenic reactivity OspC, the hindrance of access to some membrane proteins by other proteins on the spirochete's surface, effects of tick saliva proteins action.

Hiding of spirochetes is possible by invagination into fibrocytes membrane as well as, coating by antigens derived from lymphocytes B. Distribution of spirochetes is facilitated by binding to platelets through integrin aIIb b3, and to the endothelial cells through integrins av b3 i a5b1, recognition of decorin by lipoproteins DbpA i DbpB, receptor for NAG (N-acetyl glucosamina).

Endothelial cells, toxic products of granulocytes, monocytes, macrophages as well as phagocytosis counterpart in pathogenesis. Induced cytokines are connected with activation subsets of T lymphocytes involved in inflammatory response. Cytokines produced by Th1 as cytotoxic CD8 accompany the disease. Important are also dendritic cells regarded as initiators of Th1 response with participation of IL-12.

In pathogenesis of Lyme disease participation of autoimmunity is notified, especially molecular similarities between OspA and human lymphocytic antigen (hLFA-1). Neurotoxin, produced by B. burgdorferi Bbtox1 was identified. Encephalopathy signs in Lyme borreliosis could be result of releasing toxico-metabolic products, ability of spirochetes to pass the blood-brain barrier as well as, effect of lymphocytes migration. Active invasion of brain endothelium as ability to adherence to endothelial wall could be the source of focused or disseminated inflammation of brain vessels. Antiaxonal antibodies could disturb axon conduction without damaging. But damage of white matter could be connected with damage of mielin production cells, probably by antibodies, induced in cross reaction.

*****************

Abstract: Mol. Micro. (1997)

We cloned the gene encoding a membrane-interactive protein of Borrelia burgdorferi by means of its haemolytic activity in Escherichia coli. The haemolytic activity was erythrocyte-species specific, with progressively decreasing activity for erythrocytes from horse, sheep, and rabbit, respectively.

Genetic analysis of the haemolytic determinant revealed two borrelia haemolysin genes, blyA and blyB, that are part of a predicted four-gene operon which is present in multiple copies on the 30 kb circular plasmid(s) of B. burgdorferi B31.

blyA encodes a predicted alpha-helical 7.4 kDa protein with a hydrophobic central region and a positively charged C-terminus, which is structurally homologous to a large group of pore-forming toxins with cytolytic activity. blyB encodes a soluble protein which stabilized BlyA and enhanced haemolytic activity.

While the majority of BlyA in E. coli was membrane-associated, only soluble protein was haemolytically active. The haemolytic activity was shown to be highly protease sensitive, heat labile, independent of divalent cations, and extremely dependent on protein concentration, consistent with a requirement for oligomerization as the mechanism of action. BlyA was highly purified from E. coli in a single step utilizing Triton X-114 phase partitioning. Genetic analysis of blyA and blyB mutants indicated that the stability, membrane association, and activity of BlyA was dependent on subtle changes in its sequence and on the BlyB protein. The bly genes were found to be expressed at a very low level in cultured B. burgdorferi.

************

Lyme Borreliosis is a permanent infection of the brain:
Eur J Immunol. 2003 Sep;33(9):2539-50.
Pathogenesis of Lyme neuroborreliosis: Borrelia burgdorferi lipoproteins induce both proliferation and apoptosis in rhesus monkey astrocytes.

Ramesh G, Alvarez AL, Roberts ED, Dennis VA, Lasater BL, Alvarez X, Philipp MT.

Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, USA.

Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis.

In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis.

Rhesus monkeys infected by us with B. burgdorferi showed evidence of astrogliosis, namely astrocyte proliferation and apoptosis. We formulated the hypothesis that astrogliosis could be caused by spirochetal lipoproteins.

We established primary cultures of rhesus monkey astrocytes and stimulated the cells with recombinant lipidated outer surface protein A (L-OspA), a model B. burgdorferi lipoprotein, and tripalmitoyl-S-glyceryl-Cys-Ser-Lys(4)-OH (Pam(3)Cys), a synthetic lipopeptide that mimics the structure of the lipoprotein lipid moiety.

L-OspA elicited not only astrocyte proliferation but also apoptosis, two features observed during astrogliosis.

Astrocytes produced both IL-6 and TNF-alpha in response to L-OspA and Pam(3)Cys.

Proliferation induced by L-OspA was diminished in the presence of an excess of anti-IL-6 antibody, and apoptosis induced by this lipoprotein was completely suppressed with anti-TNF-alpha antibody.

Hence, IL-6 contributes to, and TNF-alpha determines, astrocyte proliferation and apoptosis, respectively, as elicited by lipoproteins.

Our results provide proof of the principle that spirochetal lipoproteins could be key virulence factors in Lyme neuroborreliosis, and that astrogliosis might contribute to neuroborreliosis pathogenesis.


____________

I dunno what it all means. But I did note that the most prominent people who publish about the neuropsychiatric aspects of LD -- Bransfield, Fallon, and Rissenberg -- seem to avoid specifically attributing Bb neurotoxins as the cause of the dysfunction, although they mention it as a possible, yet-to-be-proven factor.

[This message has been edited by minoucat (edited 12 February 2005).]


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GiGi
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It doesn't really matter which neurotoxins give us the brain fog. Somewhere I posted "What are Neurotoxins", listing many the different types of neurotoxins. Everyone of them or a multitude of them can give us the brainfog. Decreased hormonal output of the gonads and adrenals is a neurotoxin mediated problem for us. Central inhibition of the pineal gland, the hypothalamus and pituitary
is often an issue. The biotoxins from the infectious agents have a synergistic effect with heavy metals, xenobiotics and thioethers from infected teeth and root canals. It is not caused by one lowly bug - I can assure you.

The difficulty is to chose the right agent and the proper method to release the neurotoxins from their binding sites; so they can be transported to the liver and processed to eventually be carried out of the body.

I got rid of the major part of my brainfog that had lasted for almost two years - with Neural Therapy, the injection into the various ganglia (nerve centers) with a tiny needle prick and procaine to "kick" the nerve centers into action. You will have to look up Neural Therapy and how it is done and used. There is plenty of info on the net. My doctor teaches it all over the world and this is one of the first therapies he usually does. Very brief and tolerable.

I was treated for almost three months several times a week, that started to set many actions in my body in motion. Every method available followed to eliminate all neurotoxin causing foci - the main ones were the teeth in my case. It was major work. Many patients are affected by the teeth.

We also use the KMT22 (not a Rife machine). It runs a 5- hour- long channel called "Brain Clarity" addressing every focus and possible infectious agent that affects our brain function.
The KMT22 (Klinghardt Matrix Therapy) frequencies are designed to not only interefere with the reproduction of the microbes and parasites, but also to awaken the immune system, alert or entrain the white cells to recognize the invaders and at the same time help to take the medication to the body compartment where the infection actually is. Less critters, less neurotoxins to keep our brain in turmoil is the result. It does not work overnight. But steady and without major herxing.

Take care.



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Areneli
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Can you analyze snake venom from the blood?
No, there is very little of it in the blood and it is too complex to pick up with test.
That is why it is so important to get to know the species of the snake before treatment.

The biotoxin is like venom - you cannot find its presence with tests, at least not today. Its existence it deduced from clinical observations.


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Mo
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A six year old boy who proceeded to tear up Doc J's office within minutes..looked up and said:

"Mommy, I can't help it..I have bugs in my brain"

Mo


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GiGi
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Every neurotoxin, whether metals, biotoxin, xenobiotics, of which I carried enough in my body to add to my illness, could be tested by ART and treated on that basis. As they were found with ART testing, they were treated with the appropriate medicine, also determined by ART. It takes minutes to diagnose in minutes, rather than days.

Some of them can be tested by lab also, but I dare say ART is a lot quicker, costs a lot less, and is as good a guide through the disease process as any lab test. In fact, if the neurotoxin is located in a specific part of the body, that can also easily be ascertained and treated accordingly.

If a neurotoxin is found in the brain, it can be treated there in a variety of ways, such as neural therapy with the medication, laser, etc.,

If found in the kidney, same thing.

They are individually very treatable if the doctor knows how. There is no guessing.

I wish everyone had the opportunity to get help that way.

Take care.


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MADDOG
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Well,I will tell you as soon as i remember what the qusetion was. MADDOG
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MADDOG
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How funny,i reread my last post,I was about to fix the turned arround letters in the word QUESTION,then realised it was a perfect answer to the QUESTION. MADDOG
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Marnie
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An old file (cut and paste and drop it into a MS word file to print out and study):

BRAIN FOG

Brain fog includes symptoms of forgetfulness, spaciness, feelings of confusion and inability to focus and think clearly. Many people have been this way for most of their life and think this is normal.

Brain fog can be due to hypoglycemia, candida overgrowth, chronic fatigue, food reactions, nutrient deficiencies, mineral toxicity, liver, kidney or bowel toxicity, poor oxygenation, structural misalignments, medications, genetics and other causes.

Let us examine the causes.

HYPOGLYCEMIA

Hypoglycemia can cause starvation of the brain for fuel. The brain uses about one-third of all our calories. Unlike the muscles, the brain does not store any fuel. Therefore, it must have a continuous supply. If for any reason the supply varies, it is like someone varying the voltage on a delicate computer or other piece of equipment.

Common symptoms are confusion, irritability and forgetfulness and blackouts. One patient called me during a hypoglycemic episode. She couldn't remember her own name. Symptoms usually occur several hours after a meal, and may come on suddenly. Eating something that contains sugar usually relieves the symptoms in about 10 minutes.

Many people, including school-age children and many adults experience huge blood sugar swings all day long! Their breakfast of sweetened cereal, donuts or juice drives up their blood sugar. This is followed by a drop at mid-morning that is relieved by a sweet snack, more juice, soda pop or a cup of coffee. This rockets the sugar up again, followed by a fall around noon.

Lunch may include soda pop, sweetened ketchup, mustard, sweet salad dressing, sweetened rolls, chocolate milk or other sugared food. The sugar rises again, then falls rapidly at mid-afternoon. It is time for another pick-up, or maybe time for happy hour, since alcohol will lift the blood sugar again for a short time. And we wonder why many students have difficulty learning, and why thousands can't think clearly?

CANDIDIASIS

Brain fog symptoms due to candidiasis are often due to the production of alcohol and acetaldehyde by the candida organism. It causes a person to behave as if slightly inebriated, although one consumes no alcohol. Acetaldehyde is also toxic to the brain. At times, the candida organisms can themselves invade the brain.

Fruit, juices, sugar or other sweets feed the yeast organisms and in susceptible people can bring on symptoms rapidly. Carbohydrates break down to sugar in the intestines. Excessive carbohydrate in the diet can also cause symptoms, usually of a more chronic nature.

Occasionally, brain fog may be caused by yeast die-off. This may occur due to a dietary change or health program, or just a shift in metabolism. As the yeast die, they may release various toxins that induce temporary symptoms of brain fog.

CHRONIC FATIGUE

Fatigue from any cause can cause mental confusion and other symptoms of brain fog. Causes include infections, illnesses, nutritional imbalances, toxins and other fatigue syndromes. The brain requires a lot of energy. Impaired energy production for any reason profoundly affects brain function.

Infections not only drain the body's energy. They produce endo and exotoxins that may cause brain fog. Chronic illnesses such as cancer or diabetes may directly affect brain function and impair normal metabolism causing fatigue.

Nutritional imbalances are a common cause of fatigue. Toxins from insect bites, impaired digestion, exposure to chemicals and many other sources affect energy production and cause fatigue.

FOOD REACTIONS

Allergic reactions to food or beverages may directly affect energy production, leading to fatigue and brain fog. Still other food reactions cause histamine release within the nervous system. These are sometimes called `brain allergies'. Nervous system allergies can be severe, inducing irritability, confusion and even psychotic behavior.

Very commonly, food reactions irritate the intestine, causing leaky gut syndrome and the absorption of excessive toxins into the bloodstream. The most common allergic foods are wheat and cow's milk dairy. Anyone with brain fog ought to eliminate these foods from the diet, as this will often help speed recovery. Gluten-containing foods - rye, oats, and barley - also cause reactions in susceptible individuals that may affect the brain.

Some food or water-borne substances are directly toxic to the brain. These include pesticide residues, heavy metals, bacterial toxins and fungal toxins, fluoride, chlorine and other substances added to drinking water, and other water contaminants. Any of these may contribute to brain fog.

NUTRIENT DEFICIENCIES

The brain requires many nutrients, including all the vitamins and two dozen or more minerals. A range of amino acids are required for the brain, as are essential fatty acids, antioxidants and other nutrients. Among the most important nutrients are calcium, magnesium, zinc, copper, L-glutamine, L-taurine, choline, thiamine, B6, B12 and other B-complex vitamins. B-vitamin deficiency is known to cause confusion, irritability, stupor and death.

The author recalls a 7-year old patient who had recurrent ear infections. The ear infections cleared up on a nutrition program. During a follow-up visit, her mother mentioned the girl's school grades also went from Cs to As. This is not an unusual story. Though part of the reason may have been better school attendance, improved brain function is often a side effect of nutritional correction.

Electrolyte imbalance, as occurs after excessive physical exertion or sweating, often causes symptoms of brain fog. This may be due to lowered blood pressure with impaired circulation to the brain, metabolic waste products in the blood or impaired cellular energy production.

MINERAL TOXICITY

A common cause of brain fog is copper imbalance. Copper induces the production of the biogenic amines, epinephrine, norepinephrine and dopamine. Copper also affects thyroid gland activity and female hormone levels. Excessive copper or biounavailable copper often result in spaciness, mood swings, racing thoughts which can cause confusion, and excessive emotions.

Causes of copper imbalance include weak adrenal glands, zinc deficiency, stress, fatigue, birth control pills, copper intra-uterine devices or copper contamination of water supplies or food. The week before the menstrual period the copper level rises, contributing to monthly episodes of brain fog in some menstruating women.

Vegetarian diets are high in copper and low in zinc, a mineral that balances copper. These diets are also often low in other nutrients essential for the brain, like taurine, carnitine, essential fatty acids, alpha lipoic acid, B-complex vitamins and others.

High tissue levels of calcium and magnesium frequently cause diminished awareness, mental fatigue and brain fog. The condition is sometimes called a `calcium shell', as the person is literally slightly numb. Elevated tissue calcium raises the voltage at which nerve cells fire, leading to mental heaviness and numbness that is common in the population. Magnesium is required for some 500 vital enzymes. Elevated tissue levels are often biounavailable or unusable by the body.

Excessive levels of other trace elements such as iron, manganese and chromium may also affect brain activity and give rise to symptoms of brain fog.

All the toxic metals such as lead, mercury, cadmium, arsenic, aluminum, nickel, beryllium and others are neurotoxic. Brain fog may accompany any heavy metal toxicity.

LIVER, KIDNEY OR BOWEL TOXICITY

Toxicity of sluggishness of the important eliminative organs will cause symptoms of brain fog. If these organs do not do their job properly, many toxic chemicals such as ammonia remain circulating in the blood. The brain is one of the first organs affected by toxins, as it requires a lot of blood and its functions are delicate and intricate.

Sluggish eliminative organs are common today, thanks to the enormous amount of chemicals we are exposed to on a daily basis. Liver diseases such as hepatitis, alcoholic cirrhosis and others may also impair the function of the liver.

Weak digestion, intestinal infections, stress, poor eating habits or an improper diet often cause food to putrefy or ferment in the intestines. Some of the food-related toxins produced are absorbed into the bloodstream. These can easily overwhelm the normal detoxification ability of the liver and kidneys. Constipation makes the problem one hundred times worse.

Drinking inadequate water or worse, drinking soda pop, excessive coffee and other irritating beverages can damage or overwhelm the kidneys and impair their ability to remove poisons from the blood.

Finally, the liver, bowel and kidneys are affected by emotions. Liver problems may be associated with anger, intestinal problems with perfectionism and holding on, while kidney problems are associated with fear.

Be wary of cleansing programs such as fasts to correct liver and kidney toxicity. These may give temporary relief, but do not address basic causes such as food allergies, toxic chemicals in the diet or environment and nutrient deficiencies. Fasting can easily cause one to become even more nutrient deficient. I highly recommend the low-temperature sauna at least once a week for 30 minutes unless you have very high blood pressure, very low blood pressure, in which case shorter time is better. Daily skin brushing when you shower is another basic detoxification method helpful for everyone. Acupuncture, acupressure, energy balancing and other natural therapies may also be helpful to reduce the body's toxic burden.

OXYGENATION

Another common cause of brain fog is reduced oxygen to the brain. This may be due to clogged arteries, but it is often due to shallow breathing or holding one's breath. This is far more common than imagined. If it is severe enough, one may pass out. If it is mild, it can cause spaciness, confusion and impairment of cognition.

Many people under stress forget to breathe deeply and regularly. Fear or anxiety often causes holding of the breath. Sometimes a physical disease such as asthma, chronic bronchitis or emphysema impairs respiration.

STRUCTURAL MISALIGNMENT

Misalignment of the spine, or any impingement on the cranial, cervical or other nerves may cause symptoms of brain fog. The cause may be a trauma to the head or to another part of the body. However, sleeping in the wrong position, lifting incorrectly or just normal daily activities can contribute to a nerve impingement that affects the brain. Chiropractic and osteopathic manipulation, physical therapy and craniosacral therapy can be most helpful to address structural misalignments and head trauma.

MEDICATIONS

A long list of prescription and over-the-counter drugs can cause mental confusion, irritability and other brain fog symptoms. The list includes drugs for allergies, pain, high blood pressure, heart arrythmias, glaucoma, infections, depression, anxiety, inflammation and other disorders. Many people are taking two to five of these drugs at once.

Combinations of drugs may be toxic in ways that no one can anticipate. Combining medication with alcohol or recreational drugs may also produce unusual symptoms. Studies show that an important factor in mental impairment, particularly in the elderly, are the toxic effects of medications, especially combinations of drugs. Often this is misdiagnosed as Alzheimer's disease or another type of dementia.

If you must take medication, check the side effects and know that there may be side effects that are not listed on the labeling information.

OTHER CAUSES

Brain fog is occasionally caused by an illness like a brain tumor, epilepsy, meningitis or encephalitis. Electrical interference from computer screens or televisions can cause brain disturbance in sensitive people. Vision problems may affect mental clarity and cognition.

Conditions like dyslexia and autism syndromes may cause confusion, though they may also be the result of causes listed above. For example, many autistic children improve when the factors above are addressed. Emotional conditions such as neuroses, paranoia or mental fixations may cause brain fog.

CONCLUSION

Brain fog affects thousands of people and contributes to school failures, crime, delinquency, economic losses, accidents and ruined relationships.

I recommend that anyone with brain fog begin by improving their diet and lifestyle. Eliminate the junk food, excessive sugar and chemicalized foods. Eliminate wheat, dairy and other foods that may be cause reactions. Drink at least 6 glasses of filtered or bottled water every day, rather than soda pop. Be sure to get enough rest and sleep, and breathe deeply. Detoxification methods like enemas, colonic irrigation and dry sauna baths can be very helpful.

Go to a competent chiropractor or osteopath to rule out structural causes. Experiment with a diet low in sugars and starches, and perhaps try an anti-candida regimen if you suspect this cause.

If symptoms continue, consider a hair mineral test that will identify nutrient deficiencies, toxic metals, and other imbalances such as an unbalanced oxidation rate or chronic fatigue. Some people need to meditate, do therapy or other techniques to help control unwanted thoughts and emotions. Other natural therapies may also be helpful.

In a few cases, more extensive testing for allergies, illnesses and brain diseases may be necessary. Many people start with a CAT scan or an MRI. However, this is not where I would begin. Brain fog due to diet, lifestyle, toxicity, medication, spinal misalignments and blood sugar imbalance will not show up on these expensive tests. In my experience, most cases of brain fog will clear up quickly when approached this way.
http://www.drlwilson.com/articles/brain_fog.htm

Cognitive Disorders
LTS: Apart from subjective reports of diminished ability. to concentrate by LTS patients (20), no data on cognitive impairment in LTS has been found, even though the abnormal sleep found in LTS (58) might be expected to lead to transient diminished cognitive capacity.

On the other hand, severe human Mg deficiency causes brain dysfunction that can include apathy, poor memory, confusion, disorientation and hallucinations, before coma or convulsions ensue (76). Alcoholism, which has long been known to be one of the important causes of Mg deficiency (76-79), has more recently been implicated in the learning defects of infants borne to alcoholic mothers, via the resultant Mg loss-induced abnormality in regulation of the NMDA receptor (80, 81), which has been proposed to be important in learning (81,82).

Additionally, Mg administration has been shown to lessen cognitive dysfunction caused by experimental trauma (83) or directly by perinatal NMDA-induced brain damage in rats (84), mice (85) or piglets (86).

CFS: Cognitive dysfunction that includes impaired attention, loss of ability to concentrate, and memory loss is not uncommon in CFS (65,70,87-97). It is not often detectable by magnetic resonance imaging and single-photon emission computed tomography that indicate cortical lesions (95,96).

These changes may appear abruptly, and are often associated with mood changes (90). Response-related processes (91) and tasks requiring conceptually driven encoding and retrieval processes and conceptualization (92) are the findings in CFS that differ most from controls.

The overall pattern indicates a significant memory deficit, which is consistent with temporal-limbic dysfunction and differs from that of depressed patients and control subjects (94). Patients have been found to be impaired on tests of spatial span, spatial working memory, and selective reminding condition of pattern-location associated learning, but not in executive test of planning (97).

In an attentional test, eight patients were unable to learn a response set; the remainder exhibited no impairment in the executive set shifting phase of the test. CFS patients were also impaired on verbal tests of unrelated word association learning and letter fluency. Better performance on cognitive measures occurred with improvement in fatigue and depression (97).
http://www.mgwater.com/clmd.shtml

Oxidative Phosphylation and COQ10:

If Mg levels drop and along with it, B6, this impacts COQ10 levels.

CoQ10 Deficiency caused by lack of other vitamins (like Vitamin B6) the body needs to manufacture CoQ10. If CoQ10 is deficient, nerve cells in the brain and elsewhere may not have the ability to withstand the overstimulation caused by excess glutamate.
http://www.msgtruth.org/why.htm.

COQ10 regulates the ATP -generating capabilities as an electron carrier. Recent studies have shown that it transports protons for the proton gradient used to drive oxidative phosphorylation.

Hard breathing, aerobic exercise, increases oxidative phosphorylation to make ATP which may boost our immune by virtue of reducing PFK and dependent pathogens.
In addition:

``The body makes most of its own CoQ10. Physical exercise increases the body's CoQ10 supply. The remainder of CoQ10 necessary for the body is obtained from dietary sources.''
http://www.akins.com/hh/co_q10.htm



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