Marnie
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Member # 773
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Article Date: 09 Nov 2005
Scientists recently discovered an anti-aging hormone called Klotho. Now, a new study shows that this protein acts by increasing the cell's ability to detoxify harmful reactive oxygen species. The research appears as the "Paper of the Week" in the November 11 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.
The klotho gene, named after the Greek goddess who spins life's thread, is associated with preventing aging in mammals. The klotho gene product, or Klotho protein, is secreted in the blood and functions as an anti-aging hormone.
A defect in the klotho gene in mice leads to a syndrome closely resembling human aging, while overexpression of the gene extends lifespan in mice.
Now Makoto Kuro-o, assistant professor of pathology at the University of Texas Southwestern Medical Center at Dallas, has discovered one way in which Klotho extends lifespan. Using both cultured cells and transgenic mice, the researchers showed that
Klotho increases resistance to oxidative stress.
"Increased longevity is always associated with increased resistance to oxidative stress," explains Kuro-o. "Oxidative stress causes the accumulation of oxidative damage to important biological macromolecules such as DNA, lipids, and proteins that would result in functional deterioration of the cell, which eventually causes aging."
"In this study," says Kuro-o, "we propose that Klotho does its job by increasing the ability of the cell to detoxify harmful reactive oxygen species, thereby increasing resistance to oxidative stress of the body." The protein acts by
***turning on an enzyme called manganese superoxide dismutase. ***
This enzyme, found in the mitochondria of the cell, then hydrolyzes harmful superoxide into less harmful hydrogen peroxide.
This research may eventually lead to the development of anti-aging drugs, a long-standing goal of many pharmaceutical companies. "We showed that the anti-aging hormone Klotho confers resistance to oxidative stress in cells and animals," says Kuro-o. "This means that Klotho protein itself or small molecule mimetics may be potentially useful as anti-aging medicines."
In lyme there appears to be an imbalance between SOD, glutathione peroxidase and catalase (our most abundant anti-oxidant enzyme).
Bb, by virtue of using Mn, appears to be able to protect itself against the powerful superoxide free radical by triggering MnSOD. Bb appears to be able to ``handle'' H2O2 (a weak acid), but NOT superoxide.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Not sure if you're talking about Hgh(human growth hormone), but a lot of weightlifters use it. It starts diminishing as we get older. And people who use it as they get older, stay looking young.
I think the treatment is about $3,000/month. From what I have read, you have to have it injected for it to work, and there are $40 a bottle pill-form knockoffs.
I've heard that it enlarges your intestines though from long term use.
-------------------- Never walk through a cornfield backwards.
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
No, I am not talking about Human Growth Hormone.
We've had some pretty heated discussions about that a long time ago on this board.
I understand how it can HELP, but I am concerned about the "downsides".
Specifically the testosterone levels.
While some is indeed good! (and both sexes have some testosterone and estrogen - the amts. just vary - too much testosterone and we become quite hostile and engage in some pretty risky behavior.
There is also a high testosterone (too high OR too low)-prostate cancer link.
It's all about the right LEVEL.
Rebalancing all these levels is really tough!
[ 23. January 2007, 04:39 PM: Message edited by: Marnie ]
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Marnie, I take a million supplements (including, of course, magnesium of various kinds etc.). I just recently bought a bottle of Life Extension's Mitochondrial Energy Optimizer. A capsule includes: Acetyl-l-carnatine Carnosine SOD RLA Rhodiola in addition to a few others.
I notice a HUGE difference in my energy and my ability to focus when I take the recommended dose of 4 caps a day. (I tried to take 2 caps to get just a little energy and save costs, but it doesn't work....the company explains why).
It is (naturally) extremely expensive, but it is certainly doing something..... makes me break into a gallop!
~Spotted Posts: 72 | From Loudoun county, VA | Registered: Dec 2003
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Carol in PA
Frequent Contributor (5K+ posts)
Member # 5338
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quote:Originally posted by Spotted pony: I just recently bought a bottle of Life Extension's Mitochondrial Energy Optimizer.
I notice a HUGE difference in my energy and my ability to focus when I take the recommended dose of 4 caps a day.
This looked interesting, so I looked it up at iHerb.com.
Life Extension, Mitochondrial Energy Optimizer with SODzyme, 120 Capsules SRP: $82.00 Our Price: $61.50
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