Topic: Thought you should know...lurking researchers
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
1. The origin and development (pathogenesis) of lyme arthritis is dependent on the alpha(4)beta(1) mediated influx of inflammatory cells. But they do NOT influence the protective immune response. PMID: 16177120
2. What is alpha (4) beta (1)? An integrin.
3. What are integrins? Cell surface proteins. The integrins also act as cellular sensor and signaling molecules.
4. So, the development of lyme arthritis is dependent on these cell surface proteins mediating the influx of the inflammatory cells.
5. Integrin alpha (4) beta (1) mediates leukocyte recruitment, activation, mediator release and apoptosis inhibition and it plays a central role in inflammatory pathophysiology. PMID: 10072689
6. BIO 1211 appears to be an ***inhibitor*** of integrin alpha (4) beta (1).
7. What is BIO 1211? An ester.
8. What is an ester? A class of organic compounds corresponding to the inorganic salts and formed from an organic acid and an alcohol, usually with the elimination of water.
9. Okay...what else is an ester? Acetylcholine.
Now...let's go back...
Mg levels drop. This triggers a calcium influx which then triggers TNF alpha which in turn triggers angiotensin II.
Now we know that if we block angiotensin II with high doses of either Benicar or Magnesium (blocking the cholesterol pathway), this appears to cure this disease.
Keep in mind too...that:
What is in the ticks' saliva?
angiogenesis INHIBITORS. PMID 16113800.
What happens when we BLOCK angiotensin II?
It appears this RELEASES acetylcholine. IF the ``reverse'' of the following is true:
"Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for congnition." PMID 2337775.
Thus it would appear now from yet another angle that we need more acetylcholine to halt the pathogenesis of lyme disease.
Now...once again if there was enough Mg available at the outset, it would follow there would be no calcium influx, TNF alpha and angiotensin II would not climb and acetylcholine release would not be inhibited.
Like Hippocrates said, ``That which makes sick shall heal.'' All lyme symptoms are magnesium deficiency symptoms. That is what is making you sick. Magnesium levels are spiraling down. Restore the level to heal.
Other alternative paths do exist...Rife, O3 saunas, The Marshall protocol, The Na-Vitamin C protocol, IV Mg doses following Valletta's patent, and now...restoring acetylcholine levels? How much, how often, when?
Keep in mind acetylcholine is the neurotransmitter needed during REM sleep which is WHEN we make PROTEINS...including enzymes, hormones, immunoglobulins...these are all proteins.
I missed the private message sent by, I think, lymester...try again and I will link.
Posts: 9426 | From Sunshine State | Registered: Mar 2001
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Carol in PA
Frequent Contributor (5K+ posts)
Member # 5338
Acetyl L-Carnitine is an amino acid like compound that is related to choline. It may assist in the conversion of choline into acetylcholine. Acetylcholine, one of the body's key neurotransmitters, chemically transmits messages from one nerve cell to another.
Acetyl L-Carnitine
ALC is structurally related to acetylcholine, a major neurotransmitter responsible for memory and proper brain function. In Alzheimer's disease-- and to a lesser extent in the normal aging human brain--there is a defect in acetylcholine utilization. The close structural similarly between ALC and acetylcholine led researchers to begin testing ALC in alzheimer's disease. The results have been incredibly encouraging.
posted
I tried to take it and got really sick to my stomach from it. Kathy
[QB] So, would taking this supplement help?
Acetyl L-Carnitine
-------------------- You never know how strong you are until being strong is the only choice you have. Posts: 807 | From South Dakota | Registered: Jul 2005
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posted
I took it for 6 months and never saw any change. That was before I got the lyme diag. 1 1/2 years ago. As I recall it was expensive so after 6 months I didnt reorder
Posts: 561 | From connecticut | Registered: May 2004
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*Fabulous* summary of the key molecular bio issues. Fascinating. I didn't realize the key role of acetylcholine. I wish more of this information was available in current literature ( or maybe I just haven't found it).
My understanding (limited) is that the L Carnitine taken thru supplement is not bio-available via the gut to form acetylcholine.
Thanks, Marnie!
DocJen
Posts: 393 | From Washington, DC | Registered: Jun 2005
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Jellybelly
Frequent Contributor (1K+ posts)
Member # 7142
posted
Another couple of options for lowering Angiotensin II are heparin and nattokinase. Here is an abstract on Natto.
The Benefits of Nattokinase on Blood Pressure
Traditionaly in Japan, Natto has been consumed not only for cardiovascular support, but also to lower blood pressure. In recent years, this traditional belief has been confirmed by several clinical trials. In 1995, researchers from Miyazaki Medical College and Kurashiki University of Science and Arts in Japan studied the effects of nattokinase on blood pressure in both animal and human subjects (see below). In addition, the researchers confirmed the presence of inhibitors of angiotensin converting enzyme (ACE), which converts angiotensin I to its active form angiotensin II within the test extract, which consisted of 80% ethanol extract of lyophilized viscous materials of natto. ACE causes blood vessels to narrow and blood pressure to rise - by inhibiting ACE, nattokinase has a lowering effect on blood pressure.1,2
Posts: 1251 | From california | Registered: Apr 2005
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Jellybelly
Frequent Contributor (1K+ posts)
Member # 7142
posted
Here is the info on heparin blocking Angiotensin II.
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