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Med Hypotheses. 2005;64(3):438-48. Related Articles, Links
Chronic Lyme borreliosis at the root of multiple sclerosis--is a cure with antibiotics attainable?
Fritzsche M.
Clinic for Internal and Geographical Medicine, Soodstrasse 13, 8134 Adliswil, Switzerland. [email protected]
Apart from its devastating impact on individuals and their families, multiple sclerosis (MS) creates a huge economic burden for society by mainly afflicting young adults in their most productive years. Although effective strategies for symptom management and disease modifying therapies have evolved, there exists no curative treatment yet. Worldwide, MS prevalence parallels the distribution of the Lyme disease pathogen Borrelia (B.) burgdorferi, and in America and Europe, the birth excesses of those individuals who later in life develop MS exactly mirror the seasonal distributions of Borrelia transmitting Ixodes ticks. In addition to known acute infections, no other disease exhibits equally marked epidemiological clusters by season and locality, nurturing the hope that prevention might ultimately be attainable. As minocycline, tinidazole and hydroxychloroquine are reportedly capable of destroying both the spirochaetal and cystic L-form of B. burgdorferi found in MS brains, there emerges also new hope for those already afflicted. The immunomodulating anti-inflammatory potential of minocycline and hydroxychloroquine may furthermore reduce the Jarisch Herxheimer reaction triggered by decaying Borrelia at treatment initiation. Even in those cases unrelated to B. burgdorferi, minocycline is known for its beneficial effect on several factors considered to be detrimental in MS. Patients receiving a combination of these pharmaceuticals are thus expected to be cured or to have a longer period of remission compared to untreated controls. Although the goal of this rational, cost-effective and potentially curative treatment seems simple enough, the importance of a scientifically sound approach cannot be overemphasised. A randomised, prospective, double blinded trial is necessary in patients from B. burgdorferi endemic areas with established MS and/or Borrelia L-forms in their cerebrospinal fluid, and to yield reasonable significance within due time, the groups must be large enough and preferably taken together in a multi-centre study.
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Thank you for the info - I have printed it out and will take it to my LLMD tomorrow. I have dx of both LD and MS. Currently I am only on the tx for LD. Although the MS dx is concerning me, I have to be further convinced to start the MS tx. I do have lesions on the brain MRI(s) but my evoked potentials are OK. I also had a LP done which one of the two bands for MS came back positive ( but the LLNeuro told me that this band could also be positive for certian types of cancer-which I do not have- and for viral/bacterial infection ). I do have + WB from IGNEX and Babesia - this is why I made the choice that I did. The only other thing that does concern me is that I've been tx for LD for almost 2 years and have shown only slight improvement. What do yoiu think?
Posts: 128 | From Brick, NJ, USA | Registered: Dec 2003
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Wrong abx treatment. Your DR. might have not addressed co-infections.....it take stime I have been on abx for 5 years.....and definitely there is improvement...
Posts: 983 | From The sky | Registered: Feb 2005
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Boy, do I feel stupid! Dr.P & I went through areas around the World in '99...He told me that areas w/a high incidence of "ms", also had a high incidence of Lyme...What a coincidence! THANK-YOU 4 POSTING THIS ~~Reno
-------------------- ~Life's too short, eat dessert first Posts: 134 | From PA | Registered: May 2005
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Dr.P & I went through areas around the World in '99...He told me that areas w/a high incidence of "ms", also had a high ![[woohoo]](graemlins/woohoo.gif)
incidence of Lyme...What a coincidence! ![[bow]](graemlins/bow.gif)
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