posted
Found this while searching for something else and felt I should share it with the group.
The way I read this is that meningitis from strep could be stopped by administering IV phosphatidylcholine and it would stop the inflammatory process and prevent any further cell death.
Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain.
Zweigner J, Jackowski S, Smith SH, Van Der Merwe M, Weber JR, Tuomanen EI.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.
Streptococcus pneumoniae is the most common cause of bacterial meningitis of high mortality and morbidity. Neurological sequelae include paralysis, mental retardation, and learning disorders. In humans, neurons of the hippocampus undergo apoptosis as a result of meningitis.
Phosphatidylcholine (PtdCho) is an essential component of mammalian cell membranes and PtdCho deficiency, either due to chemicals or altered nutrition, leads to apoptosis, especially in hippocampal neurons.
We show that apoptosis of a variety of brain cells after pneumococcal infection arises from inhibition of PtdCho biosynthesis, the first such activity described for a bacterium. Apoptosis inhibitors did not prevent the bacterial-dependent inhibition of PtdCho biosynthesis.
Supplementation with exogenous lyso-phosphatidylcholine prevents cell death and treatment of mice with cytidine diphosphocholine attenuates hippocampal damage during meningitis, even after the onset of infection. We conclude that bacterial inhibition of PtdCho biosynthesis activates an apoptotic cascade that is a causative event in pathogenesis and amenable to therapeutic intervention.
PMID: 15238609 [PubMed - indexed for MEDLINE]
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Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004
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posted
I have been getting phosphatidylcholine in the form of a push method on and off for some time along with glutathione. Both of them are also very helfull with liver deficency issues. You also can get phosphatidylcholine in the cap form. My LLMD has the one made by Nutrasal called PhosChol- I take 6 cap per day. These two also cam up as testing very high for helping my liver issues through biofeed testing.
Posts: 582 | From milwaukee wi | Registered: May 2005
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Carol in PA
Frequent Contributor (5K+ posts)
Member # 5338
posted
After reading some of Marnie's info on this, I purchased some also.
Carol
Posts: 6947 | From Lancaster, PA | Registered: Feb 2004
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
does anyone know what phosphatidyl serine is? they add choline to it (and inositol)
is it the same as what you are taking? does the dosage matter?
thanks
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
There are more than 2 pathogens (bacterial/viral) that take the cholesterol and/or glycolysis pathways.
The above post is not surprising. At least they are getting closer...
There is more than 1 cause for cell destruction...normal programmed cell death or
PKC (protein kinsase C) inhibitors from pathogens...or man-made targeted PKC inhibitors -targeted to destroy estrogen dependent cancer cells, for example.
"Glutamate and GABA (a) levels and the status of the NMDA and GABA (a) receptors during critical growth spurt periods (called synaptogenesis) is very important to prevent neurons from dying (apoptosis)."
Elevated homocysteine levels from undermethylation.
Too much ethanol. Think alcoholism. Liver cell destruction.
Toxins (acidic) and/or too many acids/negative charges (think radiation / hit by lightning) destroy healthy cells. TOO MUCH TNF alpha (some is beneficial).
The kidney cells are esp. vulnerable from exposure to too many acids all at once.
The toxins in cigarette smoke = lung cell destruction.
To name a few.
We are supposed to be slightly alkaline. Only at death are we the most acidic.
Raise the pH. Supply more hydrogen from nutrient combos. Get the hydrogen released (vitamin E) and carried into the cells via CoQ10 (made with soybean or rice bran oil which contain the nec. nutrients + the enzyme).
Healing starts in the gut. We have to be able to absorb nutrients and to MAKE nutrients. The beneficial bacteria are very likely damaged due to the ethanol as well as the abx.
Get the liver functioning...it can help out if given a chance to do so. Tremendous stores of Mg-ATP are in the liver cells.
If using ALA...remember it "competes" with biotin...must correct.
To treat a serious mushroom poisoning...ALA, selenium and milk thistle. Lots of acids, little mineral...make what...
all together now...
HYDROGEN.
Hydrogen bonds weakly hold DNA strands together. It can be easily damaged by the free radicals. This is why the "antioxidants" are so important.
Hydrogen INactivates PFK and Mg INactivates HMG CoA reductase.
Lithium (mineral) and Depakote (acid)...or Mg and malic acid/ Mg citrate...which is safer? I think you all know which 2 I would pick! ;-)
And remember...it takes ENOUGH Mg and Ca to make HEALTHY FIGHTING antibodies...ones that work, ones that don't have a damaged "fab" portion. We MAKE our own antibiotics (antibodies) IF we have the nutrients to do so.
TIMING. The "directions" are in Valletta's U.S. patent, "Magnesium for autoimmune".
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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