posted
Hello, The printout that comes with the cyst busting drug tindamax says that it can cause cancer in laboratory animals. Also, it is usually used short term in humans.
Anyone have any info. on the safety of the longterm use of tindamax? Any experiences to share?
Is flagyl known to be any safer?
I'll continue to take my tindamax as prescribed, but I wish I didn't have such an uneasy feeling about it.
Thanks for listening, Ms. Myo
-------------------- Posts: 122 | From Texas | Registered: Jan 2005
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posted
Actually the cancer warning that is on Tindamax (Tinidazole is the same thing) comes from a study that was done on Flagyl. There is no long term study for Tindamax, but I know from experience that I would choose Tini over flagyl any day for safety and for cyst busting capabilities. It's also easier on the liver and GI tract. It's 2nd generation; Flagyl is 1st.
-------------------- You're only a failure when you stop trying. Posts: 945 | From U.S | Registered: Oct 2004
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SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
Agree 100%. Tinidazole is more advanced, better tolerated, and likely less problematic otherwise.
-------------------- Be well, Scott Posts: 4617 | From San Jose, CA | Registered: Jul 2005
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hiker53
Frequent Contributor (5K+ posts)
Member # 6046
posted
I tolerated Tindimax slightly better than flagyl(stomach wise). I believe a read a scientific report that says the study about flagyl causing cancer was flawed. Of course, now I can't remember the source.
However, I think any antibiotic taken for a long period has its dangers. Good luck. Hiker
-------------------- Hiker53
"God is light. In Him there is no darkness." 1John 1:5 Posts: 8890 | From Illinois | Registered: Aug 2004
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posted
In addition to pulsing the tindamax, I am on bicillin shots and oral zithromax. As far as I understand it, the tindamax is just to bust open the cyst form and the other antibiotics do the killing.
Maybe someone else who knows more than I do can illuminate all this for us.
Ms. Myo
-------------------- Posts: 122 | From Texas | Registered: Jan 2005
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posted
Tini or Flagyl should always be used with another abx that will kill the keets. Supposedly, Bb can sense when it is under attack, and it will convert to the cyst form, or it can revert back to the keet form, whatever it needs to do to survive. If you go after it with just Tini, then it could very well switch to the keet form and avoid being killed. The following are snippets from articles about Tinidazole and Flagyl. It does say that it kills the cysts, not just open them up:
"On December 4, 1998 Richard Horowitz called me to say that he too had had very good results on Flagyl. We agreed to publish at the forthcoming Lyme & Spirochetal Diseases conference. The paper was not accepted for full presentation, just the poster session. Who needs new treatments when the disease is readily cured? We presented on 140 patients and I was able to meet and discuss Flagyl with many of the well known Lyme physicians.
Since then things have gone from strength to strength. Tinidazole, very similar to Flagyl, has proven to be more effective in-vitro and in-vivo. I have run out of volunteers - they are all well thankyou.
Note that these three test patients repudiate the claims of certain researchers who invoke a "post-Lyme syndrome" to explain away chronic Lyme cases. These three were treated for 6 months with conventional therapy before the addition of Flagyl. Only after Flagyl treatment did they improve and then they relapsed despite ongoing conventional therapy. Clearly there is no need to conjecture a post-Lyme condition - symptoms reflect an ongoing infection."
"Tinidazole is very similar to metronidazole. Originally I suggested that tinidazole might be more suitable for the long term treatment of Lyme disease on the basis of safety and better tolerance by the patient. Long term safety data is not available on any of the nitroimidazoles but an educated guess is that tinidazole is probably better than metronidazole.
Suprisingly when an in-vitro test was done by Brorson et al, who had done in-vitro studies of metronidazole, they reported to me, as unpublished data, that tinidazole was 10x as effective as metronidazole in killing Lyme cysts. This seems to be supported by clinical results reported from a number of physicians and patients.
Tinidazole is currently the nitroimidazole of choice in treating Lyme."
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