Anyone know of any sites I could read pertaining to any of the bone marrow diseases and Lyme?

Thanks.

I got your email, and I will email you privately. but we'll be gone all day today.

I'll be getting my lab reports, probably in the mail today, and I'll tell you what my onc said.

Darn, like we need this problem! Talk about stress...

Still praying for you for good results from you MRI.

Talk to you later,

lifeline

I just tried to find a part within your "In a Nutshell" post about bone marrow/cancer, etc, and I must have missed it.

Can you point me in the right spot?

Thanks ever so much.

"Association of Lyme Disease with Monoclonal Gammopathies: 3 Case Studies"

"In our practice of rheumatology, we have observed 3 patients treated for chronic Lyme disease who have developed monoclonal gammopathies. Patient 1 developed IgG kappa Multiple Myeloma, while patients 2 and 3 developed IgG lambda monoclonal gammopathies. Chronic Lyme Disease is a infectious disease causing a chronic systemic inflammatory condition. We propose that chronic Lyme disease and IgG monoclonal gammopathy occuring concommittantly in our three patients implies a possible pathogenetic relationship."

Also, consider the following topic about Bb in the bone marrow.

http://flash.lymenet.org/ubb/Forum1/HTML/025812.html

Also, here is an abstract from PubMed about "fibrin-ring" granulomas (whatever that is) in the bone marrow, which can be found in LD as well as in other infectious diseases.

Pathologe. 2002 Nov;23(6):465-71. Epub 2002 Oct 08.

[Differentiation of granulomatous lesions in the bone marrow]

[Article in German]

Kvasnicka HM, Thiele J.

Zentrum fur Pathologie, der Universitat zu Koln, Joseph-Stelzmann-Strasse 9,
50924 Koln, Germany. [email protected]

Granulomas are an infrequent finding in bone marrow biopsies and may be
associated with a broad spectrum of infectious and non-infectious disorders. In
this context sarcoidosis generally reveals the highest incidence of such bone
marrow lesions. Other granulomas may be encountered in drug-induced secondary
changes (toxic myelopathy) and in particular also in HIV myelopathy. In these
cases the granulomas are small, ill-defined and difficult to recognize. Special
staining methods are required to detect microorganisms. Fibrin ring granulomas
(doughnut granulomas) are typical for Q-fever, but may also be seen in reactive
conditions, after drug therapy and in the course of other infectious disorders,
such as Lyme disease. Therefore a broad serological testing should be performed.
In conclusion, in most cases the morphological findings in the bone marrow are
not specific so that a synoptical approach regarding histological, clinical and
serological data is warranted to reach the correct diagnosis.

PMID: 12436300 [PubMed - indexed for MEDLINE]

The same authors published an article in English, but it doesn't have an abstract. Here is its citation, in case you want to try to obtain a copy of it (through the interlibrary loan service department of your local public library).

Br J Haematol. 2003 Mar;120(5):723.

Bone marrow manifestation of Lyme disease (Lyme Borreliosis).

Kvasnicka HM, Thiele J, Ahmadi T.

Institute of Pathology, University of Cologne, Cologne, Germany.
[email protected]

Publication Types:
Case Reports

PMID: 12614200 [PubMed - indexed for MEDLINE]

Thank you very much for this information. I am printing this out for my LLMD plus other docs.

These bugs migrate everywhere it seems.

Thanks again.

And then that same night, I see this post.

pseudo-lymphoma AND (Lyme OR borrelia OR borreliosis)

Here they are below:

1: Leinweber B, Colli C, Chott A, Kerl H, Cerroni L.
Differential diagnosis of cutaneous infiltrates of B lymphocytes with
follicular growth pattern.
Am J Dermatopathol. 2004 Feb;26(1):4-13.
PMID: 14726817 [PubMed - indexed for MEDLINE]

2: Ghislain PD, Woestyn S, Tennstedt D, Lachapelle JM, Bigaignon G, Delmee M.
Borrelia afzelii evidenced by polymerase chain reaction in a biopsy of nipple
lymphocytoma.
Br J Dermatol. 2003 Feb;148(2):377-9. No abstract available.
PMID: 12588408 [PubMed - indexed for MEDLINE]

3: Maraspin V, Cimperman J, Lotric-Furlan S, Ruzic-Sabljic E, Jurca T, Picken
RN, Strle F.
Solitary borrelial lymphocytoma in adult patients.
Wien Klin Wochenschr. 2002 Jul 31;114(13-14):515-23.
PMID: 12422593 [PubMed - indexed for MEDLINE]

4: Grange F, Wechsler J, Guillaume JC, Tortel J, Tortel MC, Audhuy B, Jaulhac
B, Cerroni L.
Borrelia burgdorferi-associated lymphocytoma cutis simulating a primary
cutaneous large B-cell lymphoma.
J Am Acad Dermatol. 2002 Oct;47(4):530-4.
PMID: 12271296 [PubMed - indexed for MEDLINE]

5: Gissler S, Heininger U.
Borrelia lymphocytoma ("lymphadenosis benigna cutis").
Arch Dis Child. 2002 Jul;87(1):12. No abstract available.
PMID: 12089112 [PubMed - indexed for MEDLINE]

6: Cerroni L, Hofler G, Back B, Wolf P, Maier G, Kerl H.
Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia (B-CLL)
at sites typical for Borrelia burgdorferi infection.
J Cutan Pathol. 2002 Mar;29(3):142-7.
PMID: 11972710 [PubMed - indexed for MEDLINE]

7: Hwong H, Jones D, Prieto VG, Schulz C, Duvic M.
Persistent atypical lymphocytic hyperplasia following tick bite in a child:
report of a case and review of the literature.
Pediatr Dermatol. 2001 Nov-Dec;18(6):481-4. Review.
PMID: 11841632 [PubMed - indexed for MEDLINE]

8: Kerl H, Fink-Puches R, Cerroni L.
Diagnostic criteria of primary cutaneous B-cell lymphomas and pseudolymphomas.
Keio J Med. 2001 Dec;50(4):269-73.
PMID: 11806505 [PubMed - indexed for MEDLINE]

9: Cherubini M, Rizzardi C, Melato M.
[Pseudolymphoma of the breast involving the periareolar area]
Chir Ital. 2001 Sep-Oct;53(5):689-95. Italian.
PMID: 11723901 [PubMed - indexed for MEDLINE]

10: Chodynicka B, Flisiak I, Okrasinska K, Andrzejewska A, Schwartz RA.
Lymphocytoma cutis: cases linked with Lyme disease.
Cutis. 2000 Oct;66(4):243-6. No abstract available.
PMID: 11109143 [PubMed - indexed for MEDLINE]

11: Couilliet D, Guillaume JC.
[Cutaneous manifestations of Lyme borreliosis]
Ann Dermatol Venereol. 2000 May;127(5):523-7. Review. French. No abstract
available.
PMID: 10863189 [PubMed - indexed for MEDLINE]

12: von Orelli S, Schnarwyler B, Maurer R, Hirsch H, von Castelberg B.
[Vulvar pseudolymphoma: detection of infection by Borrelia burgdorferi using
polymerase chain reaction]
Gynakol Geburtshilfliche Rundsch. 1998;38(3):143-5. German.
PMID: 9885354 [PubMed - indexed for MEDLINE]

13: Sonck CE, Viljanen M, Hirsimaki P, Soderstrom KO, Ekfors TO.
Borrelial lymphocytoma--a historical case.
APMIS. 1998 Oct;106(10):947-52.
PMID: 9833696 [PubMed - indexed for MEDLINE]

14: Kaminsky P, Grignon Y, Deibener J, Maurer P, Duc M.
[Nervous system borreliosis with pseudo-lymphoma cells in cerebrospinal fluid]
Rev Neurol (Paris). 1998 Feb;154(2):170-2. French.
PMID: 9773040 [PubMed - indexed for MEDLINE]

15: Pohl-Koppe A, Wilske B, Weiss M, Schmidt H.
Borrelia lymphocytoma in childhood.
Pediatr Infect Dis J. 1998 May;17(5):423-6. Review. No abstract available.
PMID: 9613660 [PubMed - indexed for MEDLINE]

16: Hassler D.
[Dermatologic findings in Lyme-Borreliosis. 4. Borrelia lymphocytoma
(lymphadenosis cutis benigna Baferstedt)]
Fortschr Med. 1997 Nov 30;115(33):46-8. German. No abstract available.
PMID: 9480283 [PubMed - indexed for MEDLINE]

17: Berger BW.
Current aspects of Lyme disease and other Borrelia burgdorferi infections.
Dermatol Clin. 1997 Apr;15(2):247-55. Review.
PMID: 9098634 [PubMed - indexed for MEDLINE]

18: Obihara CC, de Geer DB, van Diemen-Steenvoorde JA, de Jongh BM.
[Borrelia lymphocytoma ('winter ears') in children]
Ned Tijdschr Geneeskd. 1997 Mar 8;141(10):482-4. Dutch.
PMID: 9173289 [PubMed - indexed for MEDLINE]

19: Strle F, Maraspin V, Pleterski-Rigler D, Lotric-Furlan S, Ruzic-Sabljic E,
Jurca T, Cimperman J.
Treatment of borrelial lymphocytoma.
Infection. 1996 Jan-Feb;24(1):80-4.
PMID: 8852477 [PubMed - indexed for MEDLINE]
_____________________________________________

Comment:
If you want to read any of these abstracts, then here is the link to the search page at PubMed. You can either perform the same search, exactly as I did (with parentheses and capital letters -- spell correctly), or else you can just enter the PMID # (last item) for each article into the query box and hit "go". The citation will pop up. Click on it to find the abstract. Sometimes, if the publisher's icon appears, some (not all) articles are available for free downloading from the publisher's website, while others are available for purchase.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

When I substituted the search term "lymphocytoma" for "pseudo-lymphoma" instead, I got 67 reference citations. By including all three terms for Lyme disease (Borrelia OR borreliosis OR Lyme), I can "caste a wider net" and find a lot more listed references than if I only use just either "borreliosis" or "Lyme" alone.

There is a tutorial at PubMed to learn how to design your own searches. Look for it in the sidebar on the left side of the search page.

In other words, don't panic. It might not really be malignant afterall. Do your homework first, before accepting any dire diagnosis like cancer, so that you are prepared to ask all of the right questions.

According to Trevor Marshall (at the SarcInfo-dot-com website), there is a special stain which pathologists are supposed to use to be sure it's really cancer, but unless the doctor requests it, they often don't bother to use it. For this reason, sometimes patients are told their lesions are cancerous when they really aren't. I have no idea at all what kind of special stain he was talking about, but you might want to post a question there for Trevor Marshall, if you really want to know more about this. Here's the link to the discussion "Phorum" at the SarcInfo website:

http://sarcinfo.com/phorum/list.php?f=1