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» LymeNet Flash » Questions and Discussion » Medical Questions » HLA markers and post lyme syndrome

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Author Topic: HLA markers and post lyme syndrome
lou
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J Infect Dis. 2005 Sep 15;192(6):1010-3. Epub 2005 Aug 4.
Comment in:

* J Infect Dis. 2005 Sep 15;192(6):948-9.


A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease.

Klempner MS, Wormser GH, Wade K, Trevino RP, Tang J, Kaslow RA, Schmid C.

Boston University School of Medicine and Boston Medical Center, Massachusetts 02118, USA.

In a comparison of 95 patients with systemic symptoms that persisted after antibiotic treatment for acute Lyme disease (posttreatment chronic Lyme disease) and 104 control subjects without such symptoms after antibiotic treatment, we sought associations between human leukocyte antigen class II (DRB1 and DQB1) markers and posttreatment chronic Lyme disease. No strong association between posttreatment chronic Lyme disease and any class II allele or genotype was found.

PMID: 16107953 [PubMed - indexed for MEDLINE]

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seibertneurolyme
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Thanks Lou!!!!!

Really needed this reference to argue with insurance company that hubby does not have a "post Lyme autoimmune movement disorder". He didn't even have the specific HLA markers the doc expected to find when the genetic testing was done, but of course the office notes list this as a diagnosis.

The full journal article is free and can be found here.

http://www.journals.uchicago.edu/JID/journal/issues/v192n6/34407/34407.text.html

Bea Seibert

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