...to see the mention of tyrosine...on page one. It is a very, very important clue!
Use your edit feature to find the word "borrelia" to zoom into the paragraph.
Now...about tyrosine...the lowly amimo acid.
It is ONE of the things that INactivates NFkB.
NFkB (an enzyme) is believed to cause the prolonged course of this disease.
Now...
There is an MAO enzyme, actually 2 of them - MAO A and MAO B.
MAO B looks to be linked to Try326 (tryosine).
If Bb is using OUR tyrosine, thus lowering MAO -B is this -> an INCREASE in MAO A?
In other words if MAO B is down, MAO A goes up and then LESS norepinephrine, serotonin and dopamine are available...perhaps.
If we block MAO A -> INcreased Norepinephrine, serotonin and dopamine. But tyramine (tyrosine as it is broken down) increases too, normally.
You've likely heard of MAO inhibitors before. And how one had to be careful what they ate when they were on them. They were the "antidepressants" of old.
"The newest class of MAO compounds is the MAO A Inhibitor (RIMAs) * These compounds are much safer than the older MAO inhibitors that are irreversible
Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA, a type of monoamine oxidase inhibitor (MAOI)) and acts on epinephrine (adrenaline), norepinephrine (noradrenaline), serotonin, and dopamine.
Unlike standard MAOIs, possible side effects do not include cardiovascular complications (hypertension) with encephalopathy, liver toxicity or hyperthermia.
A single 300mg dose of moclobemide inhibits 80% of monoamine oxidase A (MAO-A) and 30% of monoamine oxidase B (MAO-B),
blocking the decomposition of
norepinephrine, serotonin and, to a lesser extent, dopamine. No reuptake inhibition on any of the neurotransmitters occurs.
The pharmacodynamic action encompasses activation, elevation of mood, and improvement of symptoms like dysphoria, fatigue, and difficulties in concentration. The duration and quality of sleep may be improved. In the treatment of depression the antidepressant effect often becomes evident in the first week of therapy (earlier as noted with TCAs/SSRIs). Moclobemide should not be taken concurrently with other antidepressants.
A washout period of two days is necessary when switching to a tricyclic antidepressant, and for SSRIs, a washout period of at least four to five half-lives is required. Fluoxetine requires a five-week washout period before beginning treatment with moclobemide."
Bb looks (to me) to be "upregulating" acetylcholine and "downregulating" norepinephrine...the 2 major neurotransmitters that are present in both the brain and body.
The difference is Bb is using
C-acetyltransferase to make acetylcholine
NOT N-acetyltransferase to convert serotonin-> melatonin, a very powerful antioxidant which works best in an alkaline environment.
Alka Max by TriMedica and SOD by Solar Ray should help with the antioxidant status.
Vitamin E, too, of course.
Too many free radicals. Too MUCH nitric oxide.
Incidentally, in a pinch, Mn will "sub" for Mg.
Bb wants Mn, not Mg...it would appear.
Posts: 9426 | From Sunshine State | Registered: Mar 2001
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posted
is there any way to state this in simpler terms? i would like to understand what you are saying, but can't fathom it.
Posts: 73 | From connecticut | Registered: Aug 2006
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posted
Does this mean that we should be replacing the lost manganese that Bb uses? as we do with the Magnesium. Or are we feeding it by adding more Manganese.
And the Tyrosine if it inactivates NFkB then what you are saying is it would be beneficial to add it as a supplement?
Posts: 465 | From New York, NY | Registered: Aug 2005
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posted
You might want to ask your doctor about that. My LLMD insisted that I NOT take any manganese since it feeds the Borrelia. He said that was very important.
He suggested that I do take magnesium, but he said never, ever take manganese because the Borrelia is dependent upon it for its metabolic functions. It's been a while, but we discussed whether or not to supplement magnesium or manganese at the link below, if you are interested.
Thank you for this information. I have received Manganese in IV vit drip and by IM with other vitamins.
This is confusing - My thinking was too simple I guess. I thought if the Bb uses magnesium we replace that. Then if it is dependent on the Manganese- it is using it up and therefore one could become depleted.
I will certainly omit the Manganese from the drip if I am actually helping Bb in it's metabolic process.
I will read the link that you provided.
And the only concern I had about the IV's was should I be using glutathione if I still have amalgams.
Yikes! What you don't know can kill ya.
Posts: 465 | From New York, NY | Registered: Aug 2005
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GiGi
Frequent Contributor (5K+ posts)
Member # 259
posted
There is evidence that some workers exposed to manganese in manganese mining suffer from Parkinsons symptoms.
I do not think it is wise to supplement any single minerals unless you or your doctor tests that you have a deficiency and actually should have it. Same with single amino acids.
Take care.
Posts: 9834 | From Washington State | Registered: Oct 2000
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Below is a quote from Marnie from the previous discussion link I gave you up at the top of this post. I think it sums it up pretty well.
Marnie said, ``It is a Mg deficiency that I am most concerned about because Mg is needed to make ATP, controls most of the enzymes, is needed to make healthy antibodies...''
I know that LLMD Dr. B feels that it is important to supplement magnesium, as did my LLMD. It did make a difference in my symptoms, although even IV magnesium and IM shots were not enough to treat my disease without proper antibiotic therapy.
You will have to ask GiGi about the use IV glutathione with amalgams. She would know much more about that than I would. I didn't have amalgams, but I did find glutathione very helpful. These days I don't take any supplements anymore. I did for many years, though.) I'm finally at 99.9% as a result of proper treatment and I'm glad not to have to worry about the expense or any of the rest of it. Sorry that I can't help you more but it's my bedtime.
Good night all : )
Posts: 487 | From USA | Registered: Feb 2002
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charlie
Frequent Contributor (1K+ posts)
Member # 25
posted
welders often have symptoms resembling parkinsons from the manganese in welding rods...I've seen some with that kind of 'shaking palsy'.
Posts: 2804 | From Texas | Registered: Oct 2000
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
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