Topic: Lyme & multiple sclerosis associated with lymphoma
Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
1: Med Hypotheses. 2006 Dec 29; [Epub ahead of print]
Lyme borreliosis and multiple sclerosis are associated with primary effusion lymphoma.
Batinac T, Petranovic D, Zamolo G, Petranovic D, Ruzic A.
Department of Dermatovenerology, Rijeka University Hospital, Kresimirova 42, 51000 Rijeka, Croatia.
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by chronic inflammation and demyelination. Studies suggested that the viral, especially Epstein-Barr virus infection, and bacterial infections, especially Borrelia burgodorferi infection, play a role in etiology of MS.
MS prevalence parallels the distribution of the Lyme disease pathogen B. burgdorferi. Criteria used for diagnosis of MS can also be fulfilled in other conditions such as Lyme disease, a multisystem disorder resulting from infection by the tick-borne spirochete, B. burgdorferi.
In the late period of Lyme disease demyelinating involvement of central nervous system can develop and MS can be erroneously diagnosed. A Lyme borreliosis can mimick central nervous system lymphoma.
Also, B. burgdorferi has been implicated not only in etiology of MS, but also in etiology of lymphoma.
Studies suggested that there is an increased risk of non-Hodgkin lymphoma in patients, who had a history of autoimmune diseases such as MS and that both non-Hodgkin's lymphomas and Hodgkin's disease were associated with Epstein-Barr virus infection.
A small group of lymphomas called primary effusion lymphomas (PEL) is a recently individualized form of non-Hodgkin's lymphoma (WHO classification) that exhibit exclusive or dominant involvement of serous cavities, without a detectable solid tumor mass.
These lymphomas have also been linked to Epstein-Barr virus and human herpes virus type 8 infections but virus negative cases have been described.
Therefore, we propose that MS and neuroborreliosis are linked to central nervous system primary effusion lymphomas.
As a first step in confirming or refuting our hypotheses, we suggest a thorough study of CSF in the patients suspected for the diagnosis of MS and Lyme borreliosis.
PMID: 17197115 [PubMed - as supplied by publisher]
posted
i recall having read that b-cell lympoma(s) disappeared after abx treatmet. archives on one of the, non-flash-discussion sectionsa, though, i don't recall which section.
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MagicAcorn
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Member # 8786
posted
Wow !
Interesting - thanks for posting this.
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posted
With low CD 57 levels (natural killer lymphocyte)reported in Lyme patients, this kind of correlation with a malignancy is not surprising.
These cells have search and destroy duty for malignant cells.....not to mention that the infection could serve as the oncogenic stimuli to develop the malignancy to begin with and then with a reduced immune response.....It is scary....
?????
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kelmo
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Holy Cow...one more thing to think about. Thanks for posting this. I have a teenager, and they seem to be the majority of hodgkin's victims.
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MagicAcorn
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I have a teenager, and they seem to be the majority of hodgkin's victims.
I thought the same thing Kelmo.
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northstar
Frequent Contributor (1K+ posts)
Member # 7911
posted
Jackie Kennedy Onassis died from non-hodgkins lymphoma. She was avid horsewoman, and frequented Martha's Vineyard (not sure that is spelled right), and grew up in that area.
Northstar
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AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
Thanks, Tincup!
Excellent information!
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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