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» LymeNet Flash » Questions and Discussion » Medical Questions » TISSUE BOUND IMMUNE COMPLEXES

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Author Topic: TISSUE BOUND IMMUNE COMPLEXES
Al
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When a foreign substance enters the body it is an offender called an antigen which elicits a response from our immune defenses. The immune system will detect the antigen and then release immunoglobulins called antibodies that confront the antigens. The antibodies are Y shaped. One leg attaches to the antigen and another leg attaches to another antigen. Another antibody may attach to the same antigen with one leg and another antigen with the other leg. As this process continues a larger molecule is formed composed of antigens and antibodies. These are known as immune complexes. They are important in the elimination of such structures as bacteria, viruses, fungi, ect.. They immobilize the offenders and stimulate the body's scavenger cells (macrophages) and their relatives the monocytes to immobilize the offenders. This is the non-specific defense system. Every immune complex transmits signals to other body defenses to come and destroy it. The command is for its own destruction. Macrophages are ideal for this job. They engulf the immune complex and break it down enzymaticly. This is not sufficient, so the immune complex then alarms the death squad called the compliment system which has nine principle components with many different enzymes. These are protein degrading enzymes. These plasma proteins and glycol proteins are a powerful weapon in the body's defense system. Their job is to destroy by bursting bacteria, viruses, ect. and prepare for removal by the macrophages. This is done by coating the particles with the compliment proteins. The third function is regulation of the immune responses. This is accomplished by mediators that lead to migration of specific cells such as monocytes, the release of histamine and activation of adhesion molecules.
Histamine is needed to produce hydrochloric acid (stomach acid). The continuous release of histamine causes excess acid in the stomach. I believe this to be the major cause of acid reflux. Mass cell activation may also cause flushing, palpitations, shortness of breath, headache, light headiness, hypertension, and syncope. An increase in urinary methyl histamine, a marker of mass cell activation, can be found in these patients. Mass cell activation results in the vasodilator histamine, which may also contribute to postural orthostatic tachycardia.
This is a simple view of the immune system, so without going into this complex system any further lets focus on tissue bound immune complexes, which has been ignored by the medical establishment for decades. In order for the immune system to successfully do its job tissue bound immune complexes must be broken down. Hydrolytic enzymes have proven to do just that. Studies with multiple sclerosis and rheumatoid arthritis have been successful using hydrolytic enzyme combinations. It may be possible, that an antibiotic treatment for an infection while breaking down the tissue bound immune complexes would bring about eradication of the organism and a normalization of the immune system. Only time will tell that the microbes that causes lyme disease, babesia, bartonella, ect. can be treated successfully in this manner. Research looks promising.

Posts: 789 | From CT, | Registered: Jun 2006  |  IP: Logged | Report this post to a Moderator
Tincup
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Ignore Betty when she changes your post around.

[Big Grin]

Al..

Gotta wonder.. why did you post this here tonight? It's like you KNEW I needed it!

I am THRILLED!!! But stumped! I have been researching myself stupid trying to find EXACTLY this kind of info!!! And here it is.. suddenly.... right under my nose!

NO where have I found it explained any better. The other stuff I've located is so stinking complicated, I'd never absorb it all.

Soooooooooooooooo...

THANK YOU!

And.. now that I've done an adequate job of sucking up...

What do you know about C4a being elevated?

Doc just contacted me as mine is elevated... and I was just ordered to have more blood work.

The C4a results are suppose to be between 0-2000.

Mine is over 9,000.

Trying to figure out what that means.. and if it is like most other stuff.. and nothing can/should be done for it?

Any assistance appreciated!

[Big Grin]

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

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Robin123
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Hi Al -- people here will need you to break down your text complex into two or three lines...

So I gather there is research going on with hydrolytic enzymes?

Posts: 13116 | From San Francisco | Registered: May 2006  |  IP: Logged | Report this post to a Moderator
pq
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see http://www.mucos.de for description of this.
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stella marie
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up

--------------------
Stella Marie

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luvs2ride
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Al,

This is exactly the treatment approach my doctor has taken with me. My lyme has created RA. He has me on Similase 1 3x daily with meals and Vitalzym 12 daily away from meals.

I had read earlier that enzymes taken with meals help digest the food and taken away from meals clean up the immunocomplexes.

You explain it very well and remind me of my doctor's plan of action. I've not hear of hydrolytic enzymes. I'll research it and see if I can determine if the Similase of Vitalzym include this.

Thanks.

Luvs

--------------------
When the Power of Love overcomes the Love of Power, there will be Peace.

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cantgiveupyet
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Thanks Al for this post.

Hey Tincup- My C3a and c4a are both very high. C3a is 13,000 and C4a is 9,000

here is the link to my recent post

C3a/C4a

--------------------
"Say it straight simple and with a smile."

"Thus the task is, not so much to see what no one has seen yet,
But to think what nobody has thought yet, About what everybody sees."

-Schopenhauer

pos babs, bart, igenex WB igm/igg

Posts: 3156 | From Lyme limbo | Registered: Oct 2005  |  IP: Logged | Report this post to a Moderator
Parisa
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Great post. Something new for me to research and look into.

I wonder if the Rechs Regulat (sp?) has any hydrolytic enzymes in it. It's on my ponder/possibly buy list.

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Tincup
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Hey can't...

Good post. I replied there instead of here.. cause I am a dork.

Sooooooooooooooooo.. bottom line cause I ain't gonna grasp all this stuff easily right now...

What.. in simple baby words does this all mean.. in one sentence or less..

And is there a simple way to fix it... and does it even need fixing?

Thanks for the baby talk for me!

[Big Grin]

pq.. is this link in a different language?

Luvs.. You said..

"My lyme has created RA. He has me on Similase 1 3x daily with meals and Vitalzym 12 daily away from meals."

Is it helping? You better?

Thanks for any input.

[Big Grin]

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

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AliG
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quote:
Originally posted by pq:
see http://www.mucos.de for description of this.

Hi Tincup!

Click on the British flag in the top left corner of the page for English, instead of German.
[Wink]

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

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pq
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Tincup,

sorry, just caught your response.

yes, but theres an english version, as well.

the site used to be much simpler to navigate.

i suggest reading about the use of different multi-enzyme formulations, both across medical specialties(diseases/conditions), and the uses of different multi-enzyme formulations at different phases/stages of a given disease/condition.

somewhere on the site is a summary-table of medical conditions, and the use of the different multi-enzyme formulations. this might be in the german version, which, even if it is in german, is readable/interpretable in this tabular form.

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