Hello Everyone! I copied the following info. This was a supplement my LLMD put me on my first visit. Took a month or so to make a difference. Thought I would pass it on. New Study finds D-Ribose Successful in Treating Fibromyalgia and Chronic Fatigue Syndrome
A new study published by the Journal of Alternative and Complementary Medicine found that D-Ribose significantly improves the clinical symptoms to those suffering from Fibromyalgia and Chronic Fatigue Syndrome. These conditions have been associated with impaired cellular energy metabolism, of which this double blind placebo, D-Ribose has shown to increase cellular energy synthesis in heart and skeletal muscle resulting in significant improvement. The study had five categories that were measured on a visual analog scale (VAS) which included energy, sleep, mental clarity, pain intensity, and well-being, as well an improvement in patients global assessment. Approximately 66% of patients experienced significant improvement while on D-ribose, with an average increase in energy on the VAS of 45% and an average improvement in overall well-being of 30%. For more information on the study visit www.fibroandfatigue.com.Posts: 88 | From Carnation | Registered: Feb 2007
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"The general hypothesis is that under certain pathologic cardiac conditions, nucleotides (particularly ATP, ADP, and AMP) are degraded and lost from the heart. The heart's ability to resynthesize ATP is then limited by the supply of D-ribose, which is a necessary component of the adenine nucleotide structure.
In support of this hypothesis, recent reports have used D-ribose to increase tolerance to myocardial ischemia.
Its use in patients with stable coronary artery disease improves time to exercise-induced angina and electrocardiographic changes. In conjunction with thallium imaging or dobutamine stress echocardiography, D-ribose supplementation has been used to enhance detection of hibernating myocardium.
In this article, we review the biochemical basis for using supplemental D-ribose as metabolic support for the heart and discuss the experimental evidence for its benefit. PMID: 11150394
D-Ribose (ribose) is the rate-limiting compound regulating the activity of the purine nucleotide pathway of adenine nucleotide metabolism. Ribose plays a central role in the synthesis of ATP, coenzyme-A, flavin adenine dinucleotide (FAD), nicotinamide adenine dinucleotide (NAD), vitamin B2 , DNA, RNA, and other important cellular constituents.
Ribose is the only compound the body can use to perform this vital metabolic function. Ribose is formed in the cell via the pentose phosphate pathway (PPP) of glucose metabolism....(go to link for more)
quote:Originally posted by Marnie: d ribose looks to stand for DELTA ribose!
I believe D stands for Dextro in this case. As in, Dextrorotary, which means, 'rotated to the right'. It is the one enantiomer from a chiral chemical. Where there is a D-, there is also an L-, which stands for Levorotary (Levo, rotated to the left).
"D-ribose is a sweet, solid, water-soluble substance that is also known as alpha-D-ribofuranoside. L-ribose does not have biological activity. D-ribose is sometimes referred to as just ribose. Supplemental D-ribose is produced from the fermentation of corn syrup."
So there is also an L-Ribose, which is probably useless and biologically inactive. A lot (if not most drugs), are racemic, or single enantiomers. For example, Provigil (modafinil) is R,S-modafinil. The company is currently working on making a 'cleaner', longer lasting version with just the R- isomer (will be called Nuvigil). The S isomer apparently just sort of gets in the way.
Amino acids are all mostly Levos, as that's it their naturally occuring biologically active form.
The Alpha, Beta, Gamma, Delta's are also all known as epimers. Delta just means "the 4th in a series." Hence, stage 4 sleep = delta.
"In chemistry, an epimer is a stereoisomer of another compound that has a different configuration at only one of several stereogenic centers"
"For example, the sugars α-glucose and β-glucose are epimers. In α-glucose, the -OH group on the first (anomeric) carbon is in the direction opposite the methylene group. In β-glucose, the -OH group is oriented in the same direction as the methylene group"
Isomerization is tricky to learn, and I not even going to pretend to understand it much myself. But the fact that a chemical like a tocopherol is a gamma or delta, does not give it any direct relation to a delta or other T-cell.
But back on topic! Ribose sounds cool I'd like to try it when I have some money sometime. You'd want to take large doses though, starting at 3 grams, probably more along 5+g. Beware it can cause hypoglycemia.
Inosine is made from ribose and some other things, which has been shown to cause a massive axonal growth in the brain after injury. I'd like to get both inosine and ribose.