Topic: Fluoroquinolones: an important class of antibiotics against tuberculosis.
Dave6002
Frequent Contributor (1K+ posts)
Member # 9064
posted
Curr Med Chem. 2006;13(4):455-63.
Fluoroquinolones: an important class of antibiotics against tuberculosis.
De Souza MV, Vasconcelos TR, de Almeida MV, Cardoso SH.
FioCruz-Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos-Far Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-25650 Rio de Janeiro, RJ, Brazil. [email protected]
Tuberculosis (TB) is a global health problem due to the lack of new drugs in the market and also due to the advent of multidrug resistant strains (MDR).
This disease affects around 8 million people and kills almost 3 million people each year and it is estimated that there are 1 billion infected with TB worldwide.
Due to this problem fluoroquinolones have attracted much attention as the new class of anti TB drugs due to their fewer toxic side effects, improved pharmacokinetic properties and extensive and potent activity against Gram-positive and Gram-negative bacteria, including resistant strains.
In this present review we report fluoroquinolones as a promising new class of anti TB.
PMID: 16475933 [PubMed - indexed for MEDLINE]
Posts: 1078 | From Fairland | Registered: Apr 2006
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Dave6002
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Table 1. MICs of LVFX, GFLX and MFLX Against 23 Mycobacterium Tuberculosis Isolatesa
MIC ( g/mL)b Fluoroquinolone 50%, 90%
Levofloxacin (LVFX, 3rd generation) 0.5, 1
Gatifloxacin (GFLX, 3rd generation) 0.031, 0.031
Moxifloxacin (MFLX, 4th generation) 0.062, 0.125.
Has anybody tried GFLX or MFLX, which is 10 times effective than Levaquin?
Posts: 1078 | From Fairland | Registered: Apr 2006
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Foggy
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Interesting how MDs don't question lt abx for TB, Whippets, both resistant strains. bb is a docummented virulent & resistant strain yet the other camp maligns lt abx. Posts: 2451 | From Lyme Central | Registered: Aug 2001
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Ann-OH
Frequent Contributor (5K+ posts)
Member # 2020
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Be careful with Fluoroquinolones! They can cause neuological problems and severe tendonitis, even rupture of tendons. Been there, done that.
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