posted
OCD primarily involves the brain regions of the striatum, the orbitofrontal cortex and the cingulate cortex.
OCD involves several different receptors, mostly H2, M4, nk1, NMDA, and non-NMDA glutamate receptors. The receptors 5-HT1D, 5-HT2C, and the μ opioid receptor exert a secondary effect. The H2, M4, nk1, and non-NMDA glutamate receptors are active in the striatum, whereas the NMDA receptors are active in the cingulate cortex.
The activity of certain receptors is positively correlated to the severity of OCD, whereas the activity of certain other receptors is negatively correlated to the severity of OCD. Those correlations are as follows:
NMDA μ-opioid 5-HT1D 5-HT2C The central dysfunction of OCD involves the receptors nk1, non-NMDA glutamate receptors, and NMDA, whereas the other receptors exert secondary modulatory effects.
Pharmaceuticals that act directly on those core mechanisms are aprepitant (nk1 antagonist), riluzole (glutamate release inhibitor), and tautomycin (NMDA receptor sensitizer). Also, the anti-Alzheimer's drug memantine is being studied by the OC Foundation in its efficacy in reducing OCD symptoms due to it being a NMDA antagonist. One case study published in The American Journal of Psychiatry "suggests that memantine may be an option for treatment-resistant OCD, but controlled studies are needed to substantiate this observation."[6] The drugs that are popularly used to fight OCD lack full efficacy because they do not act upon what are believed to be the core mechanisms.
Cass A
Frequent Contributor (1K+ posts)
Member # 11134
posted
Dear Thomas,
Some of the herbs in the Buhner protocol work on late-stage Lyme neurologic problems, and might help you. His book is HEALING LYME.
The situation with any psychiatric drug is that they don't really treat the source of the problem and they are very difficult to withdraw from safely. Any change of dose can cause serious problems. And, I mean SERIOUS.
You could check out the book YOUR DRUG MAY BE YOUR PROBLEM by Dr. Peter Breggin, which describes how to go about getting off psychiatric drugs safely. This should always be done under medical supervision, in my opinion.
Hope this helps.
Love,
Cass A
Posts: 1245 | From Thousand Oaks, CA | Registered: Feb 2007
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