posted
I know this was talked about in some other lyme threads here and in Bryan Rosner's new book that Plaquenil has the ability to kill the lyme disease cyst form... I would like to find a good source or information that supports this or what your thoughts are...
I am on plaquenil/Biaxin right now and I hear that Flagyl is really a knock out drug (in terms of powerful herxes) and I could imagine that if plaquenil doesn't causethe same herxes that flagyl does, then is plaquinil really that good...?
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Boomerang
Frequent Contributor (1K+ posts)
Member # 7979
posted
According to our LLMD, Plaquenil with Biaxin has a 54% response rate...for babesiosis. I think the Biaxin/Plaquenil did husband some good for a little while.
Yes, Flagyl is a "knock out" drug..... if you start it, go easy!
Posts: 1366 | From Southeast | Registered: Sep 2005
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posted
I'm currently on minocycline (100mg 3x a day), and hydroxychloroquine (plaquenil) (200mg 2x a day). I think I'm starting to feel better sometimes. I had previously been on doxycycline (200mg 2x a day) for about 2 full months, with seemingly no effects.
I'm also taking serrapeptase to hopefully increase the effectiveness of the antibiotics, as it has been shown to degrade bacterial biofilm, and increase concentrations of antibiotics like minocycline to certain areas(1). I'm taking other supplements and herbs. Anyway, here's some of the information you've requested. Thanks for bringing it up, as I just stumbled upon more research mentioned here that I hadn't read before.
------------ "At high concentrations of HCQ (256 microg/ml) about 95% of the cysts were ruptured. When the concentration of HCQ was > or = MBC, core structures did not develop inside the cysts, and the amount of RNA in these cysts decreased significantly. Spirochetal structures inside the cysts dissolved in the presence of high concentrations of HCQ. When the concentration of HCQ was > or = MBC, the core structures inside the cysts were eliminated."...(2) ------------
------------ "We recently demonstrated that the cystic forms are susceptible to metronidazole [8], but becuase of the heterogeneity of the bacteria, some strains might be resistant to this agent. Therefore, we propose that antibiotics which are used against protozoa could be of value against cystic forms of B. burgdorferi.".......
"Our results show that HCQ alone may be sufficient in the treatment of intracellular cystic forms of borreliae, since cystic forms are susceptible to this agent at concentrations which are achievable in vivo intracellularly at normal body temperature [45]. However, when the infection is located at the dermis, and when free-living B. burgdorferi circulate in the bloodstream, the MBC of HCQ is not achievable. ".......
"We have established that mobile and cystic forms of B. burgdorferi are susceptible to HCQ in vitro in a time-temperature- and concentration-dependant manner. As far as we know, this is the first susceptibility testing of cystic forms of B. burgdorferi to HCQ. We did not use metabolites of HCQ in this study, although these compounds could theoretically be more effective than the parent drug."(3) ------------
------------ "As minocycline, tinidazole and hydroxychloroquine are reportedly capable of destroying both the spirochaetal and cystic L-form of B. burgdorferi found in MS brains, there emerges also new hope for those already afflicted.
The immunomodulating anti-inflammatory potential of minocycline and hydroxychloroquine may furthermore reduce the Jarisch Herxheimer reaction triggered by decaying Borrelia at treatment initiation."(4) ------------
Here's an excerpt on the idea of using a macrolide/plaquenil combo, and possible reason why it would work, when neither drug worked well on its own... ------------ "CONCLUSIONS: These results support the hypothesis that the Lyme borrelia reside in an acidic endosome and that the use of a lysosomotropic agent augments the clinical activity of macrolide antibiotics in the treatment of patients with chronic Lyme Disease. In contrast, the efficacy of tetracycline in such patients is not affected by hydroxychloroquine."...(5) ------------
-------------------- "You know, the worst, meanest, nastiest, ticks in the world are politicks," - Steve Nostrum Posts: 242 | From South NJ | Registered: Dec 2006
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