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» LymeNet Flash » Questions and Discussion » Medical Questions » Information on Nat. Killer Cell and IP6(inositol 6-posphate)

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Author Topic: Information on Nat. Killer Cell and IP6(inositol 6-posphate)
pq
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fwiw,a patent on the description of inositol 6 phosphate and the production of NK cell count and/ or activity.
while technical, there is enouh "english" in the document to get through it.

http://tinyurl.com/hsf48

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Marnie
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Yea...phosphorus takes a hit too and this impacts many other things...

Bone health...Mg, Ca, P, vitamin D, boron...

And they only "emphasize" Ca...geeze.

Balance...it's all about the balance.

"We demonstrate for the first time that upon activation, naive NK cells release the choline phosphate-containing lysolipid PAF, which binds to perforin and acts as an agonist on perforin-induced membrane damage."
PMID: 10733503


What if the body is choline-deprived? Say, from an infection?

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pq
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with ip6 and a medical condition, some well planned regimen is needed if one is to take this at high doses, and for long time-periods.

some probable pros and cons

pro
nabs iron, thereby mitigating against the diseases and negative effects caused/promoted by excess iron in the body, some of which are: free radical production; many, if not most cancers; iron storage and processing conditions.

con

nabs di-valent cations; thats to say, minerals(= cations) with two positive charges(minerals with an electron deficient);BUT, this means both good and bad minerals(di-valent cations).

in medical conditions, and/or treatments that induce moderate to severe mineral deficits of good minerals, this could become very problematic very quickly.

so, before doing ip6, i'd do a compensatory mineral intake(w/o iron), and stagger mineral intake away in time from the ip6 intake.

taking this with untreated lyme, along with the concurrent moderate to severe magnesium deficit that lyme, and perhaps other tbd microbes cause, could mean a trip to the emerg. room within a week with some scary heart symptoms for sure. (my guess, no factual basis). little stretch of the imagination to arrive at this conclusion.


to be fair,by contrast and comparison, at least one of abx, and probably all of them in the class of tetracyclines, chelates di-valent cations,both good and bad, as well. they could be worse than ip6. who knows.
the mercury,plutonium, cadmium,and lead, as well as the magnesium, calcium and zinc--all get chelated out.

many other abx,and meds. in general also bind both good and bad minerals.

[ 15. March 2006, 12:08 AM: Message edited by: pq ]

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pq
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Marnie
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How to lyse a gram-negative bacteria (e.g. E. coli):

1. Add a chelating agent of divalent metals (e.g. EDTA) to disrupt outer membrane lipopolysaccharides

2. Add lysozyme to break up peptidoglycan layer

3. cell wall is now structurally weakened and cannot protect the protoplast from osmotic shock

4. osmotically shock the cell to disrupt protoplast and release cytoplasmic contents (i.e. high osmotic shock using sucrose solution; low osmotic shock using pure water),

5. or use mechanical shear/cavitation (French Press, Menton Gaulin press)

6. Ultrasounic

(website no longer avail. - class notes so I assume general "knowledge")

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pq
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having read about lysozyme,an enzyme in the eye, i once took an enzyme prep. containing 10mg. of lysozyme, and my left eye became watery, after months of dryness. i don't recall anything significant occuring with the right eye, but it was dry as well.

it has a physico-chemical property, difficult to explain in distillate form, that i'll post at a later date, but its has a bactericidal property for certain kinds of microbes. although i don't think it would be against Bb. not sure. nonetheless helpful. i think this belongs in the armmamentarium of enzymes.

having read about rechts regulat, i think enzymes in this product cleave bacterial membranes, creating osmotic shock.

[ 08. March 2006, 09:32 PM: Message edited by: pq ]

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Marnie
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Osmotic shock = dryness...Na problem.

Bb causes osmotic shock.

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pq
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a high sugar content of the diet will interfere with lysozyme's bactericidal action on susceptible microbes.
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Marnie
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Our OWN antibodies...if not damaged by lack of Mg and Ca to make them...can handle the cell wall form.

It's the cell wall deficient form and the cyst form that concern me.

Bowen lab seldom sees anything but the CWD form...as I remember reading.

Now...food for thought/discussion.

After dividing and what looks like "budding" ie. multiple pregnancies...

Does the "mother" pathogen shed her cell wall to "feed" her "offspring"? Are the "offspring" CWD?

Now back to osmotic shock...using a simple sugar...

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pq
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pq
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lymeHerx001
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Im taking high dosages of IP6 now.

Would the mineral deficiency come up in a standard test?

How long should I wait before I get my minerals tested.


THANKS TO ALL THE PEOPLE WHO CAN THINK!!!!!!!

I sure cant, at least not that well.

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