Topic: Aluminum-DNA bond..just talking you thru this
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
I suspect Bb uses aluminum (mineral, postive charge) to bond to our DNA (protein, negative charge).
How to break that bond?
Malic acid or
Magnesium D-aspartate combined with sodium L-glutamate or
Curcumin or
Melatonin!
NO wonder you are sleepy all the time! It appears the body is trying hard to keep your melatonin level up...as a major anti-oxidant as well as rid excess Al.
But...
Know what ELSE binds aluminum?
Chloride.
Ohhh...
We KNOW KCL can destroy Bb. Potassium + chloride.
How to get chloride back INTO the cells?
When glycine receptors are activated, Cl- enters the neuron...
Glycine.
A "lowly" amino acid.
That is needed to make...
Glutathione is called the master anti oxidant (MA) and is known as the toxic waste neutralizer of the body .
It is a small protein molecule formed from the amino acids Cysteine, Glyceine and Glutamic Acid.
Another source says:
The amino acids n-acetyl cysteine, glycine, and glutamic acid are the primary building blocks of glutathione.
The effectiveness of other anti oxidants like Vitamin A, Vitamin C, Vitamin E and Selenium all depends on he availability of Glutathione.
Lack of the MA leads to oxidative-related diseases such as accelerated aging, cell destrucion, Allergy, and asthma, among others.
Now about glycine:
Glycine is a protein amino acid found in the protein of all life forms.
It is the simplest amino acid in the body and the only protein amino acid that does not have chirality. (Note: chirality: an object which is non-superimposable on its mirror image)
Although most glycine is found in proteins, free glycine is found in body fluids as well as in plants.
The normal diet contributes approximately 2 grams of glycine daily.
Glycine is not considered an essential amino acid, i. e., the cells in the body can synthesize sufficient amounts of glycine to meet physiological requirements.
However, glycine is of major importance in the synthesis of proteins, peptides, purines, adenosine triphosphate (ATP), nucleic acids, porphyrins, hemoglobin, glutathione, creatine, *bile salts*, one-carbon fragments, glucose, glycogen, and L-serine and other amino acids.
Glycine is also a neurotransmitter in the central nervous system (CNS). Glycine and gamma-aminobutyric acid (GABA) are the major inhibitory neurotransmitters in the CNS.
Recently, a glycine-gated chloride channel has been identified in neurophils that can attenuate increases in intracellular calcium ions and diminish oxidant damage mediated by these white blood cells. Thus, glycine may be a novel antioxidant.
Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.
The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.
Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury.
Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide.
In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production.
This research is early-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS. (acute respiratory distress syndrome)
Following ingestion of glycine, the amino acid is absorbed from the small intestine via an active transport mechanism.
From the small intestine, glycine is transported to the liver by means of the portal circulation where a portion enters into one of several metabolic pathways.
Glycine not metabolized in the liver enters the systemic circulation and is distributed to various tissues in the body. Glycine readily crosses the blood-brain barrier.
Glycine may be indicated to help alleviate the symptoms of spasticity. An indication for potentiating some anti-convulsant drugs and preventing some seizures could emerge, as could an indication for its use in managing schizophrenia.
Research in progress also suggests usefulness in some cancers. There is no evidence to support use of glycine as an ergogenic aid, and it is too early to say whether it can play any useful role in lipid metabolism. There are no well-designed clinical trials to support its use in benign prostate hypertrophy.
Glycine first attracted interest in the medical research community for its reputed ability to dampen reflex excitability in the CNS.
A pilot study of its effects on severe chronic leg spasticity
(most of the subjects were suffering from chronic multiple sclerosis)
yielded improvement in spasticity and mobility of the lower limbs, rated at about 25% overall. The dose used was 1 gram daily for six months to a year. All patients noted some benefits, and no adverse events were recorded.
Other researchers have since reported that glycine can potentiate some but not all anticonvulsant drugs in some animal models. It has also been shown to prevent some experimentally produced seizures.
The effects of oral glycine (200 mg/kg/day) were tested in two siblings suffering from 3-phosphoglycerate dehydrogenase deficiency, an inborn error of L-serine biosynthesis.
A significant amount of glycine is made from L-serine. Among the features of this disorder are intractable seizures. L-serine in doses up to 500 mg/kg/day failed to control the seizures, but oral glycine completely stopped them, and electroencephalographic abnormalities resolved after six months of treatment.
High-dose glycine may be beneficial in the management of enduring negative symptoms of schizophrenia.
Twenty-two treatment-resistant schizophrenic patients participated in a double-blind, placebo-controlled, six-week, crossover treatment trial with 0.8 grams per kilogram daily of glycine added to their ongoing antipsychotic medication.
Glycine intake ranged from 40 to 90 grams daily. Only mild gastrointestinal side effects (nausea and vomiting) were reported in one patient taking glycine. Patients taking glycine experienced significantly diminished negative symptoms. Followup studies are planned.
Recent animal studies suggest that glycine may have some anti-cancer properties.
In one recent study, 51 weeks of glycine supplementation did not stop early foci formation of cancer but
reduced formation of small liver tumors by 23%, medium-sized tumors by 64% and large tumors by nearly 80% in rats given an agent that is a peroxisome proliferator and liver carcinogen.
In another recent study, dietary glycine inhibited B16 melanoma tumors in mice. Glycine-supplemented mice had tumors that were 50 to 70% smaller in size than those in controls.
The protective mechanism in this case appeared to be inhibition of angiogenesis effected by
suppressed endothelial-cell proliferation.
Tumors in mice fed glycine had 70% fewer arteries than were present in the tumors of controls.
Whether very preliminary data suggesting some positive effects of glycine on lipid metabolism will be mirrored in human research remains to be seen.
Partly because glycine is a precursor of creatine, some have assumed that it might have some of the same ergogenic potential that has been claimed for creatine.
This, so far, has not been demonstrated. Glycine is claimed to be beneficial for benign prostatic hypertrophy based on a dated clinical study that has never been confirmed.
Glycine supplementation is contraindicated in those hypersensitive to any component of the preparation. It is also contraindicated in those who are anuric (some glycine gets converted to ammonia).
PRECAUTIONS
Glycine supplementation should be avoided by pregnant women and nursing mothers. Because of some conversion of glycine to ammonia, those with hepatic impairment should avoid glycine supplementation unless prescribed.
ADVERSE REACTIONS Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tolerated.
INTERACTIONS Antispastic drugs. Theoretically, supplemental glycine might have additive effects when used in conjunction with baclofen, diazepam, dantrolene sodium and tizanidine.
No other drug, nutritional supplement, food or herb interactions are known.
OVERDOSAGE There are no reports of overdosage in humans. The majority of mice receiving 3 to 4.5 grams per kilogram by intravenous infusion experienced bradycardia, prolongation of the PQ interval, QRS duration and death.
DOSAGE AND ADMINISTRATION Glycine is available in 500 milligram tablets and capsules. Those who supplement use up to 1 gram daily in divided doses. Doses used for management of schizophrenia have ranged from 40 to 90 grams daily.
Because glycine is an amino ACID...I think it is wise to take a sugar - alkaline - in conjunction.
It looks like d-ribose might be a good one.
In addition...to further "repair the mitochondria" - powerhouses - I particularly like Juvenon, by Professor Bruce Ames of Berkeley. Juvenon contains carnitine which comes from L-tyrosine and L-methionine. I highly suspect lyme patients are undermethylated (low methionine).
How did this all come about?
Bb doesn't grow in gelatin. Gelatin is a complete protein. It is particularly high in glycine. When researching glycine, I found an article that said it wasn't "optically active".
That hit a key. Light does not effect it.
At NIGHT when the Western Fence Lizard goes hunting for insects to eat, it is covered in ticks that have Bb in them. However, when the ticks are full and fall off, they are no longer infected. There is something in that lizard's blood that is capable of killing Bb (Robert Lane, Berkeley).
Insects produce glycine as a defense. That lizard, hunting at NIGHT, has to have a high level of THAT optically INactive amino acid in its blood (in additon to others).
Now...since all the amino acids sort of compete for entry into the cells, it maybe necessary to take the supplements apart - time wise. D-ribose with glycine separate from Juvenon.
I do not have any idea about how much D-ribose and glycine. The bottle of Juvenon says 1 or 2 separate or together once a day.
I would go slow and see what happens with the D-ribose and glycine. Then I would slowly "ramp up".
Yes, I do think Mg is still needed. However, while I have been promoting Mg citrate (citrates INactivate PFK), it now looks like we are really trying to ACTIVATE PFK...PFK1...to halt PFK2 being triggered. Bb is depleting this enzyme (PFK1). PFK1 low -> PFK2 triggered to produce glucagon, to trigger insulin (activates PFK1) to carry sugar into the cells.
So..the form of Mg to use might well be Mg malate (magnesium + malic acid because malic acid is another thing that can chelate Al) OR Magnesium D-aspartate. Mg needs to be taken with a nice small dose B complex.
For researchers, why Mg?
CONCLUSIONS: These data suggest that short-term magnesium sulfate administration results in increased inhibition of the ion channel.
This effect is also continued with prolonged treatment, along with decreased sensitivity of the N-methyl-D-aspartate receptor channel complex to its agonists glutamate and glycine.
This proposed time-dependent, twofold effect may provide insight into the mechanisms of magnesium sulfate's central anticonvulsant effect. (Am J Obstet Gynecol 1996;175:575-81.)
Normally Mg and Zn control the NMDA (glutamate) receptors. With those minerals low...it appears other factors come into play.
Ancora Imparo!
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
P.S. in case you are wondering about the components of glutathione re: cysteine...
ALA (R form is best, by far) comes from cysteine. It is a co-enzyjme for pyruvate dehydrogenase and a- ketoglutarate dehydrogenase. Lipoic acid is reduced to DHLA which reduces the amino acid cystine to cysteine.
Nobody cares to learn here?
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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cactus
Frequent Contributor (1K+ posts)
Member # 7347
posted
Thank you, Marnie - I was excited to see this post.
Great info!
-------------------- �Did you ever stop to think, and forget to start again?� - A.A. Milne Posts: 1987 | From No. VA | Registered: May 2005
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Hi Marnie, Thanks for the recent posts. I haven't been on Lymnet much since late last fall until recently...too much going on and ups and downs with my health from weeks of trying to meet work deadlines, family problems and more family problems created by the holidays and recently herxing from quinine while getting through a flooded basement, #2 son's college graduation & Mother's Day while hosting a ungrateful relatives with only one asking me about my health...and I have to go through it all again this coming weekend for #3's high school graduation. (At least my younger sister who was so totally rude to me and insulted me with my parents just sitting there - hubby was not around but the next day he did call her after she left and nicely told her to get a hotel room next weekend.)
I had decided a couple of weeks ago that I needed to change to Mg-malate, but finances are low and I have a lot of Mg-citrate, especially since things have been so hectic on my good days that I have forgotten to take more than one 400mg pill.
Dr. C had convinced me that I should be taking Vit D3 at my last appt (April 27) and it was cheap so I started taking it...but now have quit it as I have been outside trying to get house ready for these graduations and also have a small garden planted.
When I was trying to figure out how to save our yard a couple weeks ago, I came across the humates and today I read more about fulvic acid, so I wanted your opinion and thought I would also post a notice for others to read.
-------------------- God's mercies are new every morning.
Karla Posts: 85 | From KANSAS | Registered: Jul 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Fulvic acid...interesting. I will try to research more later, but meantime...
fulvic acids have higher oxygen but lower carbon contents than the high - molecular..
That stuck out...
less carbon, higher oxygen...as in D-ribose, a 5 carbon chain (not 6) needed to make RNA which just happens to differ from DNA because it contains an oxygen molecule.
Been working on a letter to those who are calling the shots...
We gotta get chloride into the cells. Into our neutrophils as well as the endothelial cells that Bb is inhabiting.
"When glycine receptors are activated, Cl- enters the neuron."
Glycine binds Al.
Normally Mg and zinc and glycine and glutamate impact the NMDA (glutamate) receptors. With Mg, Zn and glycine low...up goes glutamate.
Ouch...Chinese Restaurant syndrome. MSG...monosodium glutamate.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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