Expert Review of Anti-infective Therapy October 2007, Vol. 5, No. 5, Pages 759-762 doi:10.1586/14787210.5.5.759
Lyme disease: a turning point Raphael B Stricker and Lorraine Johnson � Author for correspondence Sections: ChooseINTRODUCTIONReferences
Lyme disease is one of the most controversial illnesses in the history of medicine [1,2]. Over the past decade, two opposing camps have emerged in the controversy over this tick-borne illness.
One camp is represented by the Infectious Diseases Society of America [IDSA], which maintains that Lyme disease is a rare illness localized to well-defined areas of the world.
According to the IDSA, the disease is `hard to catch and easy to cure' because the infection is rarely encountered, easily diagnosed in its early stage by means of accurate commercial laboratory tests and effectively treated with a short course of antibiotics over 2-4 weeks. Chronic infection with the Lyme spirochete, Borrelia burgdorferi, is rare or nonexistent [3].
The opposing camp is represented by the International Lyme and Associated Diseases Society (ILADS), which argues that Lyme disease is not rare and, because its spread is facilitated by rodents, deer and birds, it can be found in an unpredictable distribution around the world accompanied by other tick-borne coinfections that may complicate the clinical picture.
According to the ILADS, tick bites often go unnoticed and commercial laboratory testing for Lyme disease is inaccurate [1,4]. Consequently, the disease is often not recognized and may persist in a large number of patients, requiring prolonged antibiotic therapy to eradicate persistent infection with the evasive Lyme spirochete [1,4].
The battle over chronic Lyme disease has taken some unprecedented turns. As of 2007, more than 19,000 scientific articles about tick-borne diseases have been published, and the dichotomy between basic science studies and clinical research articles is striking: while basic science studies continue to highlight the invasiveness and elusiveness of B. burgdorferi in culture systems and animal models, clinical research articles adhere to the dogma that B. burgdorferi produces a limited infection that is eradicated easily [5,6].
Patients with persistent symptoms are labeled as having `post-Lyme syndrome', hypothesized to be an autoimmune response to the previously eradicated infection. To date, attempts to elucidate the autoimmune mechanism of post-Lyme syndrome have been unsuccessful [7,8].
While IDSA followers have embraced the post-Lyme syndrome concept and foresworn long-term antibiotic treatment, followers of the ILADS have continued to use antibiotics to treat persistently symptomatic Lyme patients for chronic infection with B. burgdorferi and coinfecting tick-borne agents. They cite animal studies that demonstrate persistent infection by a complex organism, as well as numerous clinical reports that document failure of the standard 2-4 weeks of antibiotic therapy recommended by the IDSA [1,9-12].
The controversy came to a head in November 2006 when the IDSA released new guidelines severely limiting treatment options for patients with persistent Lyme symptoms [3]. The guidelines were so restrictive that the Attorney General of Connecticut [USA] initiated an unprecedented investigation into possible antitrust violations by the IDSA, the dominant infectious disease society in the USA, in its formulation of the guidelines [13,101].
To support its restrictive stance on Lyme disease, the IDSA cites a study by Klempner and colleagues published in the New England Journal of Medicine in 2001 [14]. Sponsored by the US NIH, the trial examined a well-defined cohort of patients with persistent symptoms of Lyme disease despite treatment with standard antibiotic therapy.
The patients were randomized to receive either placebo or 1 month of intravenous ceftriaxone followed by 2 months of oral doxycycline. Treatment was administered in a blinded fashion and response to treatment was evaluated with a validated quality-of-life outcome tool in an intent-to-treat analysis. The conclusion of this randomized, controlled trial was that patients who received 90 days of antibiotic therapy were no more likely to improve than patients who received placebo.
In fact, 60% of patients in the study either stayed the same or became worse, regardless of treatment. The results of this investigation were interpreted as showing that long-term antibiotic therapy is ineffective for patients with persistent symptoms of Lyme disease [15,16].
Owing to the prestigious nature of the study sponsor and publisher, this interpretation was circulated widely in the medical literature and the lay press, and was immediately adopted by insurance companies, who used the study results to deny antibiotic therapy beyond the 2-4-week IDSA limit to patients with chronic Lyme disease. As a result of the IDSA's promotion of the study conclusions, chronic Lyme disease ceased to be a treatable infection in the eyes of the medical community.
Physicians who continued to treat beyond the IDSA limit risked medical board sanctions or medical license revocation based on this solitary study [11].
More than 5 years after publication of the Klempner article, the `over-reaching impact' of the study has finally been challenged. Cameron examined the generalizability of the Klempner study findings in terms of the patient cohort, the treatment regimen and subsequent studies of prolonged antibiotic therapy in chronic Lyme disease [17].
Patients in the study cohort had been sick for an average of 4.7 years and had been treated with an average of three courses of antibiotics, making this a `retreatment' study of patients who had already failed similar therapy. Furthermore, based on the health-related quality-of-life scale that was used, the treatment regimen was inadequate for the degree of functional compromise in these patients in terms of intravenous antibiotic duration and oral antibiotic dose.
Cameron concluded that the study represents a `too-little too-late' approach to a highly selected, extensively treated patient group that differs significantly from more typical chronic Lyme patients who are either untreated or undertreated. Based on the lack of generalizability of the study results, the blanket interpretation that long-term antibiotics are ineffective for chronic Lyme disease is invalid [17].
Subsequent randomized, placebo-controlled trials of antibiotic treatment in chronic Lyme disease have failed to support the conclusions of the Klempner trial [Table 1]. Krupp et al. showed that 1 month of intravenous ceftriaxone improved the primary outcome measure of fatigue in a cohort of chronic Lyme patients [18].
For the other two primary outcome measures, cognitive function remained unchanged and borrelial antigen persisted in cerebrospinal fluid in a subset of patients after this relatively short treatment course (1 vs 3 months in the other placebo-controlled trials described here). Of interest, patients who had not received previous intravenous antibiotic therapy did significantly better than controls in terms of improvement in fatigue [69 vs 0% improvement; p < 0.01].
This observation underscores the significance of prior treatment failure and the poor generalizability of the Klempner trial. Three cases of life-threatening sepsis occurred in the placebo group [11%] versus none in the ceftriaxone group [0%]. This finding demonstrates the relative safety of indwelling catheters when antibiotic therapy is administered through these catheters [19] [Stricker RB, Unpublished data].
Conversely, the risks of placebo treatment with these catheters may limit future controlled trials of long-term therapy in chronic Lyme disease.
In two additional studies, Fallon et al. showed that retreatment with 10 weeks of intravenous ceftriaxone improved cognitive and physical function in chronic Lyme patients [20]. Although improvement in physical functioning was sustained for 14 weeks after treatment cessation, cognitive improvement was not.
The investigators employed a highly sensitive testing system to define the cognitive deficits in their patients [21]. Cameron showed that 90 days of oral amoxicillin improved quality of life in a similar group of patients [22]. In this study, patients with the best initial quality of life did significantly better with retreatment than patients with the worst initial quality of life.
Cameron noted that patients with the best quality of life were significantly different from patients in the Klempner trial in terms of baseline level of dysfunction and treatment failure rate [22]. In a subsequent analysis, Cameron found that poor quality of life was associated with delay of initial antibiotic treatment, a variable that was not examined in the Klempner trial [23].
Taken as a whole, these studies support the conclusion that longer antibiotic therapy is effective in subsets of patients with chronic Lyme disease, and that adoption of the opposite interpretation based on the Klempner study is premature.
In the absence of consensus regarding the diagnosis and treatment of Lyme disease, the battle will continue over appropriate treatment of patients with persistent symptoms of this tick-borne illness [24]. It is helpful to recall that B. burgdorferi shares certain pathophysiological features with mycobacterial and other chronic infections, including secretion of autoinducer enzymes designed to resuscitate dormant organisms [25], signaling via the same cell receptors [26] and induction of immunosuppressive factors [10,27-29]. Furthermore, chronic infection with these organisms may require prolonged antibiotic therapy [6-36 months], and the risks of long-term treatment are considered justifiable in those situations [24].
The lesson here is that the medical community should keep an open mind regarding treatment options for Lyme disease and not jump to conclusions based on a solitary study with poor generalizability.
Financial & competing interests disclosure RB Stricker serves on the advisory panel for QMedRx Inc.. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Posts: 48 | From New Jersey | Registered: Aug 2007
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Greatcod
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Stricker said "Cameron found that poor quality of life was associated with delay of initial antibiotic treatment, a variable that was not examined in the Klempner trial [23]."
A major factor in Lyme treatment, never much discussed on this forum. Thanks for posting this.
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Greatcod
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I take a doxy if I spend even a little time in the woods. I heard Nancy Shattick, a Seteerite researcher, say that's what she did if she even suspected a bite. I think the issue of lenght of time before treatment starts is central to any discussion of Lyme. Probably the most important factor in any form of treatement of Lyme. People here discuss their treatment's effectivenss, ABX or alternative, seldom mentioning how long they were infected since that treatment started..One of my biases in all this is at the end of my second year, I experienced a vast improvement without treatment other than resting a lot.
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Geneal
Frequent Contributor (5K+ posts)
Member # 10375
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What if you never saw the tick that got you?
Never got a rash?
Like me and so many others on this board.
Makes delay of diagnosis a no brainer.
Then add in the months and years of misdiagnosing and voila! Chronic Lyme....
I really like that the study was finally picked apart for threats to validation.
Hugs,
Geneal
Posts: 6250 | From Louisiana | Registered: Oct 2006
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Don't smack me - but....I think that ALL doctors are right in the matter of "what they have learned. Kinda like anyone who studies anything.
You take what you learn to be gospel and don't want to believe that there is another way(treatment) out there.
BUT....Every commericial that I see on tv about our local hospitals talks about how medicine is an evolving science. And, they BRAG on and on about how they will research to come up with new and better ways to treat all illnesses. (Does that include Lyme Disease?)
I have to wonder??? And that will be my first question to the new doc we are being sent to.
Maybe antibiotics are not the way..but it sure seems to help MANY MANY MANY people (if they would only research more then 90 days and a handful of people.
As a mother of a LD infected daughter, I will stop at nothing to make sure she receives the best care and treatment that I can find. I just wish that our medical profession would do the same.(Maybe if it were their daughter or son)
There is more then one way to look at anything. Why do "they" (IDSA AND ILADS) choose not to finding something better by working together then.
And..Why should the patients have to suffer in the mean time.
If ILADS has found something that works for the time being (even though the long term antibiotic use has side effects that are SOOOO bad, accoridng to IDSA) then work together to find something that has little or no side effects -
But they don't even seem interested in doing that much for patients with LD.
It's a conspiriacy, I'm telling ya!
-------------------- Those who say it can't be done, should get out of the way of those who are doing it! Posts: 34 | From South Dakota | Registered: Sep 2007
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Like I said in an earlier post...I never used to be a conspiracy Theororist...
Until Now.
LM
Posts: 212 | From Eastern CA | Registered: Apr 2007
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CaliforniaLyme
Frequent Contributor (5K+ posts)
Member # 7136
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Good article.
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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