susank
Frequent Contributor (1K+ posts)
Member # 22150
posted
I have read that after infection ie viral/bacterial/whatever that the IGM's eventually go away - but the IGG's remain. Also have read that with LD IGM's can persist. In the past I have tested positive for HHV6 and EBV - but that was years ago. My last EBV the VCA IGM was neg. Point: on the LD WB I continue to have positive IGM bands - some repeating - from first test end 2008 to third test beg 2011. IGM bands repeating: 18 and 66 twice, 41 three times, and 34IND twice. Cross-reaction these bands years after one would assume the IGM would have faded? Other diseases than LD can have IGM come and go? TIA.
-------------------- Pos.Bb culture 2012 Labcorp - no bands ever Igenex - Neg. 4 times With overall bands: IGM 18,28,41,66 IND: 23-25,34,39 IGG 41,58 IND: 39 Bart H IGG 40 Posts: 1613 | From Texas | Registered: Aug 2009
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posted
I don't know about others.. but for sure lyme does.
"With most infections, your immune system first forms IgM antibodies, then in about 2 to 4 weeks, you see IgG antibodies. In some infections, IgG antibodies may be detectable for years.
Because Borrelia burgdorferi is a chronic persistent infection that may last for decades, you would think patients with chronic symptoms would have positive IgG Western blots.
But actually, more IgM blots are positive in chronic borreliosis than IgG. Every time Borrelia burgdorferi reproduces itself, it may stimulate the immune system to form new IgM antibodies."
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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susank
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Member # 22150
posted
Yes - hence my wondering why I continue to have pos. IGM LD bands. To complicate: auto-immune diseases are not tested with IGM/IGG values? My symptoms fit Sjogren's and LD/Bart. For Sjogren's IIRC the values are Ro and La or such. Past five years have had five Sjogren's tests - blood - and all neg. I know that one can have "S" and be sero neg. "S" would be considered chronic. Wonder if one has "S" if that would skew/cross-react with LD IGM? Other auto-immune diseases can do that? Wonder what bands they would "appear as"? I also have more IGM than IGG bands. FWIW.
-------------------- Pos.Bb culture 2012 Labcorp - no bands ever Igenex - Neg. 4 times With overall bands: IGM 18,28,41,66 IND: 23-25,34,39 IGG 41,58 IND: 39 Bart H IGG 40 Posts: 1613 | From Texas | Registered: Aug 2009
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Lymeorsomething
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Member # 16359
posted
IGMs can persist in chronic lyme. They have for me and via a Lap Corp WB most recently. I doubt EBV is factor...very common and it reactivates when lyme is active.
I've had a pos band 31 confirmation too. So my main issue seems to be stubborn lyme infection despite fairly heavy treatment thus far.
I'll be throwing the kitchen sink at for the next several months. Unfortunately, I think some people are resistant to treatment for a variety of reasons.
-------------------- "Whatever can go wrong will go wrong." Posts: 2062 | From CT | Registered: Jul 2008
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susank
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Member # 22150
posted
Quick search seems to indicate that with Sjogren's the IGG's are usually elevated. Mine obviously not - having CVID. How many times a day do I wonder if I have Sjogren's or LD............
-------------------- Pos.Bb culture 2012 Labcorp - no bands ever Igenex - Neg. 4 times With overall bands: IGM 18,28,41,66 IND: 23-25,34,39 IGG 41,58 IND: 39 Bart H IGG 40 Posts: 1613 | From Texas | Registered: Aug 2009
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quote:Originally posted by Lymeorsomething: IGMs can persist in chronic lyme.
- That is correct. That is what I posted.
Having Sjogren's is a moot point because the treatment involves steroids. Don't think you want to go there.
I am positive for Sjogren's. No biggie.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96222 | From Texas | Registered: Feb 2001
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susank
Frequent Contributor (1K+ posts)
Member # 22150
posted
Tutu - thanks. I cannot remember - did you test positive on the "S" blood tests? Also, if you don't mind my asking - what are your positive bands? I don't know what Dx I would consider the worst. My worst symptoms have to do with dryness - eyes and mouth. My eyes hurt so badly and are so sensitive to light/sun/glare - and I mean really really bad. The only official Dx I have is CVID - subnormal IGG total and subclasses and subnormal IGA subclasses. That throws a monkey wrench in things for sure. Last night when I found the site that said most Sjogren's patients have elevated IGG levels - I was able to think for a few hours that perhaps it really is not S. Then of course it came to my mind that perhaps CVID -would interfere with that reasoning. Thoughts? I am inclined to think LD caused CVID and not vv.
-------------------- Pos.Bb culture 2012 Labcorp - no bands ever Igenex - Neg. 4 times With overall bands: IGM 18,28,41,66 IND: 23-25,34,39 IGG 41,58 IND: 39 Bart H IGG 40 Posts: 1613 | From Texas | Registered: Aug 2009
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