LymeNet Flash: Tickborne disease study in NE Italy and Slovenia

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Tickborne disease study in NE Italy and Slovenia

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Topic: Tickborne disease study in NE Italy and Slovenia

Sue vG
Frequent Contributor (1K+ posts)
Member # 3143

posted

Anybody read Italian? I just got back from a vacation to the Friuli- Venezia Giulia region of NE Italy, and lo and behold, here is an article on tickborne diseases in the area. (Zecche = ticks)

http://www.friulinews.it/modules.php?op=modload&name=News&file=article&sid=1495&mode=thread&order=0&thold=0

I don't know enough Italian to get the details (and Babelfish was no help), but at least they're going to study the incidence of Lyme and coinfections in the Carso (Karst) area of far NE Italy and Slovenia, particularly around Gorizia, as well as the pre-alpine areas (the hills leading up to the Alps -- wine country).

Maybe it'll take having the European Union validate this disease for the US to take it seriously enough to do their own (unbiased) research.

Posts: 1307 | From TX | Registered: Sep 2002 | IP: Logged |

Truthfinder
Frequent Contributor (1K+ posts)
Member # 8512

posted

Sue, there have been studies coming out of the Slovenia region for quite some time.... and I've been paying attention because one strain of Bb - B. bissettii - is known to cause severe illness in Slovenia, and the same strain (or extremely similar) has been found in several states in the U.S.

No one here in the USA is yet admitting that this strain can cause infection in humans, but of course, until there is actual research, we just sit here and wait and wonder.

Here are a couple of excerpts I have in my files:

*****************************************************

http://www.geocities.com/HotSprings/Oasis/6455/burgdorferi-links.html

1999 Dec;289(5-7):643-52.

Lyme borreliosis in Slovenia.

Strle F.

Department of Infectious Diseases, University Medical Centre Ljubljana, Slovenia.

....... The source material of human isolates has been skin, blood, cerebrospinal fluid, as well as synovial tissue and fluid. Thus far four Borrelia species were found by isolation to cause disease in humans: B. afzelii, B. garinii, B. burgdorferi sensu stricto, and B. bissettii. The majority of typed isolates belong to B. afzelii, but B. garinii slightly predominates among strains cultured from cerebrospinal fluid. Lyme borreliosis has been mandatory reportable in Slovenia for the last 11 years. It is the most common tick-borne disease and is present all over the country. The incidence has been increasing......

**************************************

http://home.pon.net/caat/lyme/research1.htm

... There are over 150 strains [of Borrelia] in the US and still counting..... The strains can vary a great deal in their effects on the human body.

.... Moreover, strains genetically similar to those of B. bissettii from New York, California, South Carolina, and Florida have been isolated from several humans in Slovenia. Those patients had clinical presentations ranging from relatively benign illness to some severe afflictions.

Some of the patients had variable and unpredictable serologic responses, including a lack of antibody response despite disseminated disease (29). Interestingly, some of the Lyme disease patients in the southern United States also lacked a serologic response to antigens derived from B. burgdorferi sensu stricto (9). More isolates of B. bissettii from humans and especially isolates from the United States need to be studied to allow a better understanding of its frequency and pathogenicity in humans.

... Considerable phenotypic heterogeneity was found among strains described from California and Colorado (26, 35), and substantial genetic diversity was reported among a large number of North American strains (24) on the basis of genomic macrorestriction analysis and ospA and rrl gene sequencing. Our study emphasizes that the genetic diversity among American strains is much greater than previously thought.

.... It is not known whether B. bissettii sp. nov. and the other novel genomic groups can infect humans.

--------------------
Tracy
.... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�.

Posts: 2966 | From Colorado | Registered: Dec 2005 | IP: Logged |

sonicbmx
LymeNet Contributor
Member # 12949

posted

this translation is brought to you by the courtesy of Sherlock on my Mac!
--
sonicbmx

----------------------------------------

"It introduces to you today near Knows it Cammarata to it of the
University of Trieste of a realized Interregional plan from

investigators of the giuliano athenaeum and the University of Lubiana, in collaboration with the guards of the Slovenian forest

Body. They were present, between the others, the prorettore of the University of Trieste, prof. Fabio Ruzzier, the responsible of

the plan, prof.ssa Marine Cinco, microbiologist of the Department of biomedical Sciences of the University of Trieste

and Dr. Alfredo Altobelli, ecologist of the Department of Biology of the University of Trieste. In recent years, several diseases

transmitted from carriers (between which the zecche) they are riemerse and they are diffuse in Europe and elsewhere

with important consequences on the sanitary, economic and social plan. In the greater part of the cases that is legacy to local

or total changes, which the climate and the various impact exercised from the man on the atmosphere. It becomes

therefore important to catalogue, in the European ecosystems, the variations it acclimatizes them that they can influence the

distribution spaces them and temporal of transmitted pathogenic agents by means of carriers. The zecche of the

species "Ixodes ricinus" they act as from carriers that condition the transmission of burgdorferi pathogenic agents which

"Borrelia" (disease of Lyme)"virus Tbe" (encephalitis turn them), "Anaplasma phagocythophilum" (anaplasmosi) and "Rickettsia

spp" (rickeziosi) and their presence determines the degree of risk to the transmission of the infection. With the scope of

mappare the territory constituted from the Friuli Venice Julia and from wrap transfrontaliera Italia/Slovenia in relation to the risk

to be infects to you, through the bite of mint, from agents of diseases which morbo of Lyme, encephalitis it turns them,

anaplasmosi and rickeziosi, has been realized this plan, supported from the European Community in the within of the

communitarian Program Interreg III Italia/Slovenia and
put into effect in the arc of 24 months in period 2005-2006.

The processing of the data is finished in the past june. In the first phase the investigators have supplied to collect zecche in

some areas of the territory, selected on the base of their characteristics from the point of view of the climate and the

vegetation, beyond that representative of 4 main biogeografiche areas. In these stations the collection campaigns have been

organized three times to the year (spring, summer, autumn). In
all the collected exemplary have been

search the agents to you infecting by means of biomolecolari
techniques of "Pcr" and have been calculated the index of

territorial risk, that is the number of zecche infette for 100 mq of examined territory. Turned out E' that the risk is distributed

various to second of several the infecting agents searches to you: for "B. Burgdorferi", agent of the disease of Lyme, it is

maximum in the triestine Carso and goriziano transfrontaliero (20-18 zecche /mq), followed from the prealpine atmosphere;

he is instead bottom (Kranjska Gora, Socchieve) if not quite null (Valcanale, Val Pesarina) in the alpine atmosphere. The number

of the zecche infette has been always greater in the primaverile season. Premised that this is the first study in which the Tbe in

the carrier is evidenced virus mint in our E region is also the first relationship documented on the forehead of advancing (or

withdrawal) of the infection turns them in the South
Europe; the risk infection from virus Tbe is important along

wraps it transfrontaliera, above all in Slovenian territory. Less disseminated it turns out the presence of the others two

pathogenic agents, and that is of "Anaplasma phagocytophilum" and "Rickettsia". Of these, the second introduces variable indices

of risk from 0 to 4.6, with one disomogenea territorial distribution and in agreement with the meager number of

human cases attributable to these pathogenic ones. The area
of greater prevalence seems however to be the zone centers

them of the Friuli Venice Julia, to horse between wrap it alpine and prealpine. Since it is important to calculate the risk on the

territory in the space and in the time, the comparison of the percentages of infettivit� for biennium 2005-2006 evidences an

increment of the presence of Rickettsia in all the area survey object, in particular in wraps prealpine, while, in the two years it

examines to you, do not find variations in the presence of "B. Burgdorferi". The data epidemiologists, regarding the infettivit�

from "Borrelia burgdorferi", have been correlate to you with the main ecological factors that of it condition the distribution.

Through the analysis multivaried statistics it has been gained a model that has permission, through the Gis techniques, of

spazializzare the risk upgrades them of infection from "Borrelia burgdorferi" for all the region Friuli Venice Julia. The parameters

acclimatize meant them to you in the model, are the amount and density of the vegetation, skin temperature, superficial humidity,

trofiche appearance of the vegetation, resources (abundance of caprioli), altitude and average anniversary of the temperature.

The first three parameters have been obtained from the
satellitari data that allow to a cover much width of the territory

and a continuous monitoring. The model characterizes in the area of the goriziano and triestine Carso the zone rischiosa than

to contract the disease and, between the factors it acclimatizes considers them you, a weight greater assumes it the presence of

the caprioli and the medium temperature anniversary. Studies of this kind acquire greater meant if predisposed in key statistical-

thunderstorm to the aim of monitorare evolversi, or less, of the risk zecche on the regional andtransfrontaliero territory. It would

be therefore opportune riproporli annually, in order at least a lustro, so as to to estimate, also in perspective, the effective

incidence of the phenomenon."

--------------------
"The hell with Drs.. we have each other!"
My story began here:

http://forums.wrongdiagnosis.com/showthread.php?t=16210
http://forums.wrongdiagnosis.com/showthread.php?t=7833
http://forums.wrongdiagnosis.com/showthread.php?t=6873

Posts: 127 | From Van Nuys, CA | Registered: Aug 2007 | IP: Logged |

Truthfinder
Frequent Contributor (1K+ posts)
Member # 8512

posted

Thanks, Sonic, that was a very interesting read, but I still don't know what it said.

[Smile]

--------------------
Tracy
.... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�.

Posts: 2966 | From Colorado | Registered: Dec 2005 | IP: Logged |

Sue vG
Frequent Contributor (1K+ posts)
Member # 3143

posted

Thanks for the input, Truthfinder and Sonicbmx. The good news is that they recognize that there's a potential problem and want to understand it to be able to do something about it (unlike this country, where they KNOW there's a HUGE problem and won't admit it).

Posts: 1307 | From TX | Registered: Sep 2002 | IP: Logged |

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