LymeNet Flash: *58-kDa (not GroEL)?

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»	LymeNet Flash » Questions and Discussion » Medical Questions** » 58-kDa (not GroEL)?*

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Topic: *58-kDa (not GroEL)?

wiserforit
LymeNet Contributor
Member # 9732

posted

I have a friend who is deathly ill and down to 90 lbs. with every symptom on the Lyme list for the past 14 months of non-treatment. Besides weight loss, she hasn't had any consistent sleep since July.

Like so many sero-neg folks, she's been to about 18 ID Ducks & Co. -- they've told her what they think she doesn't have within the realms of their specialties and they offer valium and sleeping pills.

She finally went to a LLMD who did testing. The testing showed nothing other than elevated ANA (immune system marker?) and a positive on the 58-kDa marker.

I looked it up on the Newbie info Western Blot link and it said "*58-kDa (not GroEL)" -- what does that mean?

She feels so uncertain about Lyme since the tests aren't "proving" anything definitive.

Anybody able to give some helpful info about 58-kDa?

Thanks in advance --

wiserforit

Posts: 508 | From Banks of the Hudson | Registered: Jul 2006 | IP: Logged |

treepatrol
Honored Contributor (10K+ posts)
Member # 4117

posted

(not GroEL) versus (GroEL)
GroEL belongs to the chaperonin family of molecular chaperones, and is found in the bacteria E coli. It is required for the proper folding of many proteins in the bacteria.
So its not that protien chaperone its specific to that particular bacteria not GroEL.

http://en.wikipedia.org/wiki/GroEL

What does GroEL do

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Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003 | IP: Logged |

lymednva
Frequent Contributor (1K+ posts)
Member # 9098

posted

Treepatrol said:

quote:
(not GroEL) versus (GroEL)
GroEL belongs to the chaperonin family of molecular chaperones, and is found in the bacteria E coli.

It is required for the proper folding of many proteins in the bacteria.
So its not that protien chaperone its specific to that particular bacteria not GroEL.

Huh??!?!

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Lymednva

Posts: 2407 | From over the river and through the woods | Registered: Apr 2006 | IP: Logged |

wiserforit
LymeNet Contributor
Member # 9732

posted

say tree --

Thanks for your reply!

what does it mean in the scheme of Lyme -- if anything?

[confused]

wiserforit

Posts: 508 | From Banks of the Hudson | Registered: Jul 2006 | IP: Logged |

Lemon2Lyme
Member
Member # 13561

posted

Well, just ask your friend if the LLMD did an Igenex test (I'm assuming Igenex would be used though.)

I had IGG bands 58 and 41 show on another lab's WB test. Then, my Igenex WB came back positive.

It may not hurt to repeat the test. Accuracy is a nightmare on Lyme tests so repeating tests or trying different type tests may be useful.

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"Whatever can go wrong will go wrong."

Posts: 36 | From Connecticut | Registered: Oct 2007 | IP: Logged |

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