LymeNet Flash: Borrelia T cell epitope associated with ABX-refractory Lyme Arthritis (Steere Dung?)

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Borrelia T cell epitope associated with ABX-refractory Lyme Arthritis (Steere Dung?)

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Topic: Borrelia T cell epitope associated with ABX-refractory Lyme Arthritis (Steere Dung?)

AliG
Frequent Contributor (1K+ posts)
Member # 9734

posted

Mol Immunol. 2008 Jan;45(1):180-9. Epub 2007

Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis.

Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. [email protected]

Antibiotic-refractory Lyme arthritis, which may result from infection-induced autoimmunity, is associated with HLA-DR molecules that bind an epitope of Borrelia burgdorferi (Bb) outer-surface protein A (OspA(165-173)) and with T cell reactivity with this epitope.

One potential mechanism to explain these associations is molecular mimicry between OspA(165-173) and a self-peptide.

Here, we searched the published human genome for peptides with sequence homology with OspA(165-173).

The two peptides identified with the greatest sequence homology with the OspA epitope were MAWD-BP(276-288), which had identity at eight of the nine core amino acid residues, and T-span7(58-70), which had identity at six residues. MAWD-BP mRNA was expressed by synoviocytes, while T-span7 mRNA was not.

However, neither peptide bound all of the HLA-DR molecules associated with antibiotic-refractory Lyme arthritis.

Among 11 patients, 9 had T cell reactivity with OspA(161-170), 6 had responses to MAWD-BP(276-288), and 3 had reactivity with T-span7(58-70), but reactivity with the self-peptides was lower than that induced by the spirochetal epitope.

Thus, there remains an association between OspA(165-173) and antibiotic-refractory Lyme arthritis, and infection-induced autoimmunity is an attractive hypothesis [Roll Eyes]

to explain this outcome.

However, molecular mimicry due to sequence homology between OspA(165-173) and a human peptide seems unlikely to be the critical mechanism.

PMID: 17555819 [PubMed - indexed for MEDLINE]

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Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006 | IP: Logged |

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