posted
I copied this from a post by Sarah/ Calalyme.
""I am allergic to sulfa too- have you heard of the G6PD deficiency? one sign of that is allergy to sulfa drugs- because you are allegic to sulfa drugs you should get a simple blood test to see if you have that because it could make a big deal with what kind of Babs meds you could take or not""
Can some one explain what the deficinacy is or provide a link??
Does it cause other problems, besides limiting the abx you can take?
I am also allergic to sulfas or so I was told....But looking way back it may have been a herx? Thanks.
-------------------- Take Care, DakotasMom01 Posts: 371 | From NJ | Registered: Dec 2007
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TerryK
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Info from the book "The Diagnosis and Treatment of Babesia" Appendix B Babesia and G6PD problems can look the same.
As many as hundreds of millions of people worldwide have some degree of G6PD deficiency. It can cause red blood cells to rupture in a way similar to most species of babesia. If one has this problem, medications as simple as aspirin or foods as basic as certain bean types can cause red blood cells to rupture.
Some have no symptoms and some have marked symptoms. Depending on your genetics, you could have a few red blood cells rupture or a lot.
This should be checked in anyone with possible babesia.
The test: Glucose 6-phosphate Dehydrogenase (G-6-PD), Quantitative, Blood and Red Blood Cell Count (CBC)
-------------------- Take Care, DakotasMom01 Posts: 371 | From NJ | Registered: Dec 2007
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CaliforniaLyme
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It is an enzyme deficiency that exists in all peoples of all countries but has higher rates in people of certain genetic backgrounds.
If you are G6PD deficient you will be allergic to sulfa drugs and depending on the kind of deficiency you have you will have reactions to certain other drugs & substances- like mothballs- fava beans- that can vary between a chronic fatigue response and hemolytic anemia.
If you are G6PD deficient and become ILL with a disease like Lyme, you may APPEAR to have blood negative Babesiosis but it could be just an activated deficiency sstate- and if you treated it with anti-malarials you could get hemolytic anemia-
It is a simple blood test to check!!! It is most common in African Americans, but that is the least lethal kind. It is common in South Asians & Asians, people of mediterranean ancestry, of arab ancestry- of jewish ancestry-
it is RARE in northern european genes but it DOES happen in EVERY population just in smaller numbers/rates-
For some peopel even aspirin can be a G6PD trigger! Can make you feel sick-
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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CaliforniaLyme
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Different genetic subtypes have to avoid different triggers- ********************************** Drugs & Foodstuffs to avoid-
Miscellaneous elements besides drugs that should be avoided Fava Beans (Some, but only some, prefer also to avoid red wine, all legumes, blueberries also yogurts containing these, soya products, tonic water).
DRUGS AND FOODSTUFF TO AVOID Drug names in red are of high risk to all deficiency types.
Name Molecular Forumla Risk Level j For whom Acetanilide (acetanilid) C8 H9 N O High Medit., Asian Acetylphenylhydrazine (2-Phynylacetohydrazide)c C8 H10 N2 O High All Aldesulfone sodium (sulfoxone) C14 H14 N2 Na2 O6 S3 High All Aminophenazone (aminopyrine) C13 H17 N3 O Low All Antazoline (antistine) C17 H19 N3 Low All Arsinec As-H3 High All Ascorbic Acid C6 H8 O6 Low All Beta-Naphthol (2-Naphthol) C10 H8 O High All Chloramphenicol C11 H12 C12 N2 O5 High Medit., Asian Chloroquined C18 H26 Cl N3 High Medit., Asian Ciprofloxacinb C17 H18 F N3 O3 High Medit., Asian Colchicine C22 H25 N O6 Low All Dapsone (diaphenylsulfone)c C12 H12 N2 O2 S High All Dimercaprol C3 H8 O S2 High All Diphenhydramine (difenilhydramine) C17 H21 N O Low All Dopamine (L-dopa) C8 H11 N O2 Low All Doxorubicin C27 H29 N O11 High Medit., Asian Furazolidone C8 H7 N3 O5 High All Glibenclamideb C32 H28 Cl N3 O5 S High Medit., Asian Glucosulfone (glucosulfone sodium) C24 H34 N2 Na2 O18 S3 High All Isobutyl Nitrite C4 H9 N O2 High Medit., Asian Isoniazid C6 H7 N3 O Low All Menadiol Sodium Sulfate (Vitamin k4 sodium sulfate)f C11 H8 Na2 O8 S2 High All Menadione (menaphtone)f C11 H8 O2 High All Menadione sodium Bisulfite (Vitamin K3 sodium bisulfite)f C11 H8 O2 NaHSO3 High All Mepacrine (Quinacrine) C23 H3O Cl N3 O High Medit., Asian Mesalazine - 5-Aminosalicylic Acid (paraminosalicylic acid) C7 H7 N O3 High Medit., Asian Methyltioninium Chloride (methylene blue) C16 H18 Cl N3 S High All Nalidixic Acidb C12 H12 N2 O3 High Medit., Asian Naphtalene, Pure (naphtalin) C10 H8 High All Niridazole C6 H6 N4 O3 S High All Nitrofural (nitrofurazone) C6 H6 N4 O4 High All Nitrofurantoin C8 H6 N4 O5 High All Norfloxacin C16 H18 F N3 O3 Low All O-Acetylsalicylic Acid (acetylsalicylic acid)a C9 H8 O4 High Medit., Asian Oxidase, Urate (urate oxidase) High Medit., Asian Pamaquine C42 H45 N3 O7 High All Para-Aminobenzoic Acid (4-Aminobenzoic Acid) C7 H7 N O2 Low All Paracetamol (acetaminophen) C8 H9 N O2 Low All Pentaquine C18 H27 N3 O High All Phenacetin (acetophenetidin)e C10 H13 N O2 High Medit., Asian Phenazone (antipyrine) C11 H12 N2 O Low All Phenazopyridine C11 H11 N5 High Medit., Asian Phenylbutazone C19 H20 N2 O2 Low All Phenytoin C19 H20 N2 O2 Low All Phynylhydrazinec C6 H8 N2 High All Phytomenadione (Vitamin K1) C31 H46 O2 Low All Primaquineg C15 H21 N3 O High All Probenecid C13 H19 NO4 S High All Procainamide C13 H21 N3 O Low All Proguanil (chlorguanidine) C11 H16 Cl N5 Low All Pyrimethamine C12 H13 Cl N4 Low All Quinidine C20 H24 N2 O2 Low All Quinine C20 H24 N2 O2 Low All Stibophen (2-(2-Oxido-3,5-Disulphonatophenoxy)-1,3,2,Benzodioxastibole-4-6-Disulphonate) C12 H4 Na5 O16 S4 Sb High All Streptomycin C21 H39 N7 O12 Low All Sulfacetamide C8 H10 N2 O3 S High All Sulfacytine C12 H14 N4 O3 S Low All Sulfadiazine C10 H10 N4 O2 S Low All Sulfadimidine C12 H14 N4 O2 S High All Sulfafurazole (sulfafurazone, sulfisoxazole) C11 H13 N3 O3 S High Medit., Asian Sulfaguanidine C7 H10 N4 O2 S Low All Sulfamerazine C11 H12 N4 O2 S Low All Sulfamethoxazoleh C10 H11 N3 O3 S High All Sulfamethoxypyridazine C11 H12 N4 O3 S Low All Sulfanilamide (Sulphanilamide) C6 H8 N2 O2 S High All Sulfapyridine C11 H11 N3 O2 S High All Sulfasalazine, Salazosulfapyridine (salazopyrin) C18 H14 N4 O5 S High All Thiazosulfone (thiazolesulfone) C9 H9 N3 O2 S2 High Medit., Asian Tiaprofenic Acid C14 H12 O3 S Low All Tolonium Chloride, Tolonium Chloride (toluidine blue) C15 H16 Cl N3 S High All Trihexyphynidyl (benzhexol) C20 H31 N O Low All Trimethoprimk C14 H18 N4 O3 Low All Trinitrotoluene (2,4,6-Trinitrotoluene) C7 H5 N3 O6 High Medit., Asian Tripelennamine C16 H21 N3 Low Medit., Asian
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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CaliforniaLyme
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Chinese Herbs to avoid if G6PD Deficient *********************************************
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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CaliforniaLyme
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It can be triggered by illness or anti-malarial drugs and it can manifest identically to blood negative BABESIOSIS- ************************************************
What is G6PD Deficiency
G6PD Deficiency is a hereditary abnormality in the activity of an erythrocyte (red blood cell) enzyme. This enzyme, glucose-6-phosphate dehydrogenase (G-6-PD), is essential for assuring a normal life span for red blood cells, and for oxidizing processes.
This enzyme deficiency may provoke the sudden destruction of red blood cells and lead to hemolytic anemia with jaundice following the intake of fava beans, certain legumes and various drugs (see a complete list of drugs and foodstuffs to avoid).
The defect is sex-linked, transmitted from mother (usually a healthy carrier) to son (or daughter, who would be a healthy carrier too; see a diagram of inheritance probabilities). This is due to the fact that the structure of G-6-PD is carried on the X chromosome: As stated by Ernest Beutler, M.D., "in females, only one of the two X chromosomes in each cell is active; consequently, female heterozygotes for G-6-PD deficiency have two populations of red cells; deficient cells and normal cells."
The deficit is most prevalent in Africa (affecting up to 20% of the population), but is common also around the Mediterranean (4% - 30%) and southeast Asia. Please note that there are more than 400 genetic variants of the deficiency. You can determine whether you are G-6-PD deficient by a simple blood test. To determine your variant, you must test yourself at specialized genetic labs.
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The symptoms Sudden rise of body temperature and yellow coloring of skin and mucous membrane. Dark yellow-orange urine. Pallor, fatigue, general deterioration of physical conditions. Heavy, fast breathing. Weak, rapid pulse.
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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A few yrs after my first bite, I got some petechie/ cherry spots, when I showed them to the dr, he said they were common in people of european decent...and nothing to worry abt.
""it is RARE in northern european genes but it DOES happen in EVERY population just in smaller numbers/rates""
I am going to ask my rheummy to test for this. I wasn't allergic to sulfas for many yrs, then suddenly it happened.
Thanks again.
-------------------- Take Care, DakotasMom01 Posts: 371 | From NJ | Registered: Dec 2007
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CaliforniaLyme
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posted
If you weren't allergic to sulfas for many years then you are not G6PD deficient!!! It is genetic so you either are or you aren't!!!
If you are G6PD deficient you are going to have a bad reaction to sulfa!!! When I took sulfa, I had to be hospitalized because my rb cells burst all over my body- I was dark red like a stain- and my lungs were affected- see this photo- like that except it was all over my face and whole body- very bad- almost died- http://www.mednet.gr/pim/images-hematology/h3_1.jpg
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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SForsgren
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Unless there is a higher incidence of this deficiency in people with Lyme and/or chronic illnesses, it seems that the rate in Northern America is 0.6% to 2.9%. It seems to be fairly rare and I am wondering whether or not there is enough of an indication to start asking for this to be tested for or not? Seems that it may not be necessary.
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