posted
I'm curious if anybody has had success with this protocol. I think the basic form is to take Minocin (Lederle Brand) 100mg Monday, Wednesday, and Friday.
It's primarly intended for mycoplasma type conditions such as RA, Fibromyalgia, CFS, etc.
I think that after the initial aggressive abx treatment most Lyme patients get, most are left with lots of Cell Wall Deficient stealth organisms (similar to Mycoplasmal infection), which low dose pulsed Minocycline is supposed to clear over long term treatment.
Any inputs?
BTW this stuff seems to be very broad spectrum. Below is a list of stuff it works against. I wonder why Minocycline hasn't received more attention!
quote: MINOCIN minocycline hydrochloride pellet-filled capsules are indicated in the treatment of the following infections due to susceptible strains of the designated microorganisms:
Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by Rickettsiae.
Respiratory tract infections caused by Mycoplasm pneumoniae .
Lymphogranuloma venereum caused by Chlamydia trachomatis .
Psittacosis (Ornithosis) due to Chlamydia psittaci.
Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescence.
Inclusion conjunctivitis caused by Chlamydia trachomatis.
Nongonococcal urethritis in adults caused by Ureaplasma urealyticum or Chlamydia trachomatis.
Relapsing fever due to Borrelia recurrentis.
Chancroid caused by Haemophilus ducreyi.
Plague due to Yersinia pestis.
Tularemia due to Francisella tularensis.
Cholera caused by Vibrio cholerae.
Campylobacter fetus infections caused by Campylobacter fetus.
Brucellosis due to Brucella species (in conjunction with streptomycin).
Bartonellosis due to Bartonella bacilliformis.
Granuloma inguinale caused by Calymmatobacterium granulomatis.
Minocycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:
Escherichia coli.
Enterobacter aerogenes.
Shigella species.
Acinetobacter species.
Respiratory tract infections caused by Haemophilus influenzae.
Respiratory tract and urinary tract infections caused by Klebsiella species
MINOCIN minocycline hydrochloride pellet-filled capsules are indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
Upper respiratory tract infections caused by Streptococcus pneumoniae.
Skin and skin structure infections caused by Staphylococcus aureus. (Note: Minocycline is not the drug of choice in the treatment of any type of staphylococcal infection.)
Uncomplicated urethritis in men due to Neisseria gonorrhoeae and for the treatment of other gonococcal infections when penicillin is contraindicated.
When penicillin is contraindicated, minocycline is an alternative drug in the treatment of the following infections:
Infections in women caused by Neisseria gonorrhoeae.
Syphilis caused by Treponema pallidum.
Yaws caused by Treponema pertenue.
Listeriosis due to Listeria monocytogenes.
Anthrax due to Bacillus anthracis.
Vincent' infection caused by Fusobacterium fusiforme.
Actinomycosis caused by Actinomyces israelii.
Infections caused by Clostridium species
In acute intestinal amebiasis, minocycline may be a useful adjunct to amebicides.
In severe acne minocycline may be useful adjunctive therapy.
I think this is a well-thought out program and I have talked with a few people who did well on it. They had other dx but, still, it might be work consideration.
I began it - several times - but cannot tolerate minocycline due to severe tinnitus and vertigo.
For those taking minocycline, B6 or NAC may help lessen effects on ears and balance. I've been trying to find something to help with that, but not there yet.
Minocycline is on many ototoxic lists, but not all of them. Some do fine. Some don't.
If any hearing or balance stuff comes from it, be sure to consult your doctor. A different med may need to be used.
I was told that the timed-released minocin is best, but my insurance would not cover that and my pharmacist said she would not order it even if I had the script and paid out of pocket.
posted
I'm on mino, but not low dose .... 100 2X daily.
Interesting psittacosis is on the list .... I was believed to have had that (vet figured it out, went to the doctor and told him what I needed and got it) .... it was the psittacosis and treatment of it that seemed to make my Lyme active again.
It's good to know that if it's lingering in my system, that I'm taking something that will get rid of it. Originally I took 100 mg. doxy three times per day for 21 days.
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
ANTIVERTIGINOUS ACTION OF B-6 ON EXPERIMENTAL MINOCYLINE-INDUCED VERTIGO IN MAN
[Article in German]
Claussen CF, Claussen E. Neurootologie, Universit�ts-HNO-Klinik W�rzburg.
By means of a former investigation it has been proved equilibriometrically that the application of 7 X 100 mg minocycline may induce a central equilibrium dysregulation of the brainstem type.
It was the purpose of this study to further assure that the minocycline induced brainstem vertigo is due to a destabilization of a supervisory gamma-aminobutyric acid (GABA)ergic loop from the archeocerebellum upon the pontomedullary vestibular regulating pathways.
As it is pharmacologically known that pyridoxine is essential for the synthesis of GABA, an inhibitory CNS neurotransmitter, 2 separate double blind trials on 20 healthy young persons each were carried out after the intake of 7 X 100 mg minocycline during 3 days with and without 7 X 40 mg pyridoxine simultaneously.
These trials were checked against an additional placebo or initial non drug investigation.
In all the 40 test persons it could be proved that the amount of vertigo and nausea symptoms was increased significantly due to the application of minocycline only.
However, when combining minocycline with vitamin B 6, the vertigo and nausea symptoms as well as the nystagmus signs from the monaural and the binaural vestibular ocular tests as well as the vestibular spinal signs from the craniocorpography recordings of the stepping and the standing procedures were remarkably reduced.
There were no statistical differences between the initial or placebo trials versus the trials with a combination of minocycline with vitamin B 6.
The same holds for the vestibular vegetative reactions, measured by the simultaneous electrocardiography during the vestibular tests.
All the equilibriometric tests applied showed a significant destabilization under the influence of a pure minocycline loading.
Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
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NAC (N-ACETYLCYSTEINE) & OTO-PROTECTION
poster's note: Gentamicin is not generally used in lyme/TBI tx and it many not be used much anymore, anyway. However, this is about NAC it its abilty to aid in oto-protection.
I make an assumption in hoping it would also help with other oto-toxic drugs if there were no other choices. More to learn.
But, as minocycline is on a few oto-toxic lists, I would sure ask a doctor about taking B6 and NAC if I were to take mino again.
Comment on: Kidney Int. 2007 Aug;72(3):359-63. (posted below)
N-ACETYLCYSTEINE IN THE PREVENTION OF OTOTOXICITY.
Tepel M.
Charit� Campus Benjamin Franklin, Medizinische Klinik IV, Nephrologie, Berlin, Germany. [email protected]
Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease.
Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients.
That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.
Gentamicin-induced ototoxicity in hemodialysis patients is ameliorated by N-acetylcysteine.
Feldman L, Efrati S, Eviatar E, Abramsohn R, Yarovoy I, Gersch E, Averbukh Z, Weissgarten J.
Nephrology Division, Assaf Harofeh Medical Center, Zerifin, Israel.
Aminoglycoside (AG) antibiotics are associated with several side effects, including a reversible nephrotoxicity and a permanent ototoxicity.
Oxidative stress is thought to contribute to the pathophysiology of both conditions. We studied the possible protective effect of the antioxidant N-acetylcysteine (NAC) in gentamicin-induced hearing loss in hemodialysis patients.
This study includes 53 hemodialysis patients scheduled to receive gentamicin for dialysis catheter-related bacteremia that were randomized to receive the antibiotic with or without NAC.
Hearing function was assessed by the standard technique of pure-tone audiograms over a range of frequencies. Audiometric evaluations were performed at baseline, 1 week and at 6 weeks after the completion of gentamicin therapy.
A total of 40 patients completed the study protocol with a mean duration of therapy of almost 15 days.
At both 1 and 6 weeks after the completion of antibiotic therapy, there were significantly more patients exhibiting ototoxicity in the control group compared with the group receiving NAC.
Additionally, significantly more patients in the control group had bilateral ototoxicity.
The greatest otoprotective effect of NAC was noticed in the high audiometric tone frequencies. Taken together, our study suggests that NAC treatment may ameliorate gentamicin-induced ototoxicity in hemodialysis patients.
PMID: 17457375 [PubMed - indexed for MEDLINE]
========
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kelmo
Frequent Contributor (1K+ posts)
Member # 8797
posted
My daughter has made the largest progress on minocycline. She started with tiny doses and worked up to 100mg 2x daily.
She recently took a break for another infection, but could hardly wait to get back on the mino.
luvs2ride
Frequent Contributor (1K+ posts)
Member # 8090
posted
I have RA and was on this protocol with 100mg Mino MWF for 1 yr.
I never felt it helped, but I kept doing it just in case. Other stuff was making obvious improvements. Mino is much more subtle. I chat frequently at the roadback website and there are many there who have great results with it.
As soon as I began with my current LLMD, she switched my mino to doxy. Same dose. Said she likes the doxy better but didn't say why. She also put me on 7 other drugs.
She just completed a genetic detox test that showed I can't eliminate drugs and she stopped all my antibiotics, plaquenil, methrotrexate. All that is except the doxy. She wants me to continue it. Again, I'm not sure why.
I did notice my most current bloodwork showed a positive reading for mycoplasmas. This is the first time I have had a positive and that may be why she continues the doxy.
Luvs
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posted
kelmo: is she doing pulsed?
Posts: 655 | From USA | Registered: Sep 2007
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johnnyb
Frequent Contributor (1K+ posts)
Member # 7645
posted
Good information.
Thanks, everyone
- JB
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kelmo
Frequent Contributor (1K+ posts)
Member # 8797
posted
No. She was pulsing in the beginning, but really wanted to give these bugs a one-two punch.
She was doing really well until insurance dropped her and her psyche meds are now all screwed up.
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