LymeNet Flash: Excellent study Treatment of human brucellosis

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Excellent study Treatment of human brucellosis

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Topic: Excellent study Treatment of human brucellosis

Monica922
LymeNet Contributor
Member # 13496

posted

Treatment of human brucellosis: systematic review and meta-analysis of randomised controlled trials

This was a metaanalysis and it was done well.
http://www.bmj.com/cgi/content/full/336/7646/701

Main results:
What is already known on this topic

Several classic combination regimens are available for the treatment of brucellosis in addition to newer antibiotics, such as quinolones

Many randomised controlled trials have assessed these regimens, though the evidence has not recently been summarised

Treatment recommendations from authoritative sources are contradictory

What this study adds

A triple drug regimen of doxycycline, gentamicin, and rifampicin offers an advantage over doxycycline with an aminoglycoside, and doxycycline-aminoglycoside regimens are superior to doxycycline-rifampicin

Quinolones are inferior to other drugs

Six weeks' treatment is associated with a lower rate of relapse than shorter regimens

Posts: 422 | From CT | Registered: Oct 2007 | IP: Logged |

Lymetoo
Moderator
Member # 743

posted

We've had several here who found out they had brucellosis, got treated and are fine today!!

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 96222 | From Texas | Registered: Feb 2001 | IP: Logged |

Monica922
LymeNet Contributor
Member # 13496

posted

Thats good news. I am a math stat geek with clincal trial expertise and this is one of the first studies that I thought was actually done well. The problem with met-analyses for Lyme is that there are no GOOD studies to combine. When you take crud and combine it statistically you still have crud..LOL. Maybe one day I will post something nice about a Lyme study I see. I sure hope they start doing some decent research to help everyone.

Posts: 422 | From CT | Registered: Oct 2007 | IP: Logged |

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