hshbmom
Frequent Contributor (1K+ posts)
Member # 9478
posted
I have a family member with "hardware". ...3 screws in one hip, one in the other. At times this person states that it feels like Lyme is attacking the metal.
I have no idea what this feels like or if it's possible, but at least you know something is going on with the hardware.
Does your LLMD think there's an autoimmune reaction going on ...or is this your orthopdedist's opinion?
Lyme likes to settle in areas that have been traumatized.
Are you taking antibiotics now?
Posts: 1672 | From AL/WV/OH | Registered: Jun 2006
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posted
Dr K says the metals are causing an allergic reaction and the ions are settling onto the myelin and it is getting attacked. Classic autoimmune reaction.
Posts: 830 | From Colorado | Registered: Mar 2005
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daise
Unregistered
posted
Hello alyalex,
There are well over 80 diseases that have been termed "autoimmune disease." However, these are more or less defined diseases.
I recall none that happen due to metal plates, etc.
However, trauma to the body can bring Lyme out of hiding. That is possible, certainly!
I think you will find this post very helpful. It was sent to me recently by a "Texas Mom," who has helped hundreds of people around the country.
This is really interesting work and makes a lot of sense to me! _____________________________
This is the latest new research about biofilms and how to inhibit their formation from the chemical engineering department at TAMU which Hubby brought home for me. It has been published in several major journals, including one of the Nature Publishing Group's journals.
It pertains to everything from nosocomial (hospital acquired) infections to cystic fibrosis and chronic ear infections in small children, as well as to biofilm infections which form on implanted medical devices, such as hip, knee and spine replacements.
It heps me understand better now why my own mother suffered from "CFS or Th1 or whatever" for the last 3+ decades of her life, following a bad car accident which fractured her hip and which required an implanted surgical steel pin to fix her broken hip.
It also makes me wonder if Pres. Reagan's so-called Alzheimer's disease might not have been caused by biofilms which formed around the bullet which enetered his body in the assassination attempt on him? Likewise, Pope John Paul's infirmities of "old age" which followed the attempt on his life?
Also, here are some more links to similar stories about his work which I found via a Google search to locate this story (since Hubby brought it home in printed format, instead of sending it to me electronically).
June 12, 2008 Researchers identify biofilms that cause infection
COLLEGE STATION, Texas -- Understanding the way bacterial cells "talk" to each other could lead to more effective methods for fighting the often persistent and serious infections caused by the biofilms they form, says a Texas A&M University professor of chemical engineering who not only has deciphered their language but also discovered how to quell their conversation.
Examining Escherichia coli bacteria -- widely considered a model organism for microbiology studies -- Professor Thomas K. Wood of the Artie McFerrin Department of Chemical Engineering at Texas A&M has succeeded in identifying, decoding and even modifying cell-to-cell signals so that biofilm formation is inhibited.
His findings are covered in a series of five published articles, two of which appear in "The International Society for Microbial Ecology Journal" -- a member of Nature Publishing Group's stable of scientific publications. In addition, his progress is detailed in "The Public Library of Science ONE," "Applied and Environmental Engineering" and in "BMC Microbiology."
Wood's work is important in addressing the widespread health issues resulting from bacteria in its biofilm form. Put simply, biofilm is a protective and adhesive slime excreted by bacteria that have joined together to form a community. The substance can grow on a variety of living and nonliving surfaces, including submerged rocks, food, teeth (as plaque) and biomedical implants such as knee and hip replacements.
And where there's an infection, there is usually biofilm.
The National Institutes of Health, Wood noted, estimate that about 90 percent of infections in humans are caused by biofilm. The Centers for Disease Control estimate biofilm to be present in 65 percent of hospital-acquired (nosocomial) infections. Biofilms have been linked to everything from gum diseases to cystic fibrosis. They typically are the cause for the fatal infections that develop post surgery. More commonly, biofilm is the chief culprit behind the nagging ear infections so common among children.
"It's been only in the last few years that pediatricians have realized that children are crying day in and day out from ear infections because it's a bacterial biofilm on their eardrums," Wood said. "Prior to that, the approach was to treat the infections with drugs that got rid of bacteria but not bacteria in a biofilm, and it was completely ineffective.
"When bacteria are growing within a biofilm, that growth takes place in a different way than when bacteria are swimming freely in suspension. Pharmaceutical firms make antibiotics to kill bacteria in suspension. Those are 1,000 times less effective on a biofilm. It's only in the last 10 years that we've realized people have died not because of free-floating bacteria but because of bacteria in a biofilm."
Wood's efforts to mitigate biofilm formation began with the recognition that construction of this substance was anything but random. To the contrary, biofilm formation is an extremely ordered process -- a fact affirmed by examining biofilm structure on a microscopic level.
Though it appears as slime to the naked eye, biofilm is actually composed of several hills and valleys of varying heights and depths. These structural differences allow for nutrients to make their way to all bacteria within the biofilm community, Wood said. Despite the numerous formations present, these pillars and plateaus seldom collide with each other. The reason for that, Wood said, is that each bacterial cell is able to "talk" to one another and signal its location so that neighboring cells do not begin construction in an occupied space. If that happened, the bottom layers of the community could be sealed off from the nutrients on which they depend, Wood explained.
In-depth examination of those critical signals by Wood and his team of researchers found that E. coli relies on a compound known as autoinducer-2 (AI-2) for biofilm formation. Each E. coli bacterium produces this compound and then releases it in the cell�s external environment. Eventually a large amount of AI-2 becomes present outside of the cells, and through a process called quorum sensing each bacterium re-absorbs the AI-2 when a specific concentration has been achieved, Wood explained. When the AI-2 re-enters the cells it activates an entirely new set of behaviors for the bacterium - in this case, signaling when and how to begin building a biofilm.
"What we're doing is examining how AI-2 is prompting the cell to make more biofilm," Wood said. "Sugars are the mortar. We identified the specific type of mortar -- the sugar known as colonic acid. We found that AI-2 helps E. coli produce more biofilm by making colonic acid, which is a kind of sugar. If you can understand how a biofilm is formed, then you can start to attack it at different stages."
And that's exactly what Wood has done.
Further research by Wood revealed that E. coli uses two different signals to control biofilm formation. Which signal is utilized depends on the temperature of the external environment, Wood said. In other words, these bacteria change their "language" if they are inside the body versus outside the body. Whereas AI-2 is the signal utilized by E. coli inside the body, Wood discovered that a compound known as indole is used for biofilm growth outside of the body -- for instance on surgical replacement parts yet to be implanted.
"The second signal that we unraveled is indole -- a derivative of amino acids," Wood said. "Amino acids are what proteins are made out of. All living things need to make amino acids. All living things make this specific amino acid called tryptophan. It turns outs E. coli converts tryptophan into indole."
Armed with that knowledge, Wood discovered a method for inhibiting biofilm formation by modifying the indole signal in a way that would confuse the bacteria. In lay terms, think of Wood's achievement as adding a few extra letters to a spoken word. The resulting gibberish is not understood by other bacterial cells in the community, and the massive construction project never gets off the ground.
"Once we realized that indole was the signal, then we could slightly modify indole by putting an OH [hydroxide] molecule on it." Wood said. "The new compound is called 7-hydroxyindole. We also found that a different type of modification would not be successful. We learned that you can trick bacteria, but you have to do it well, and another modification does not have any effect on stopping biofilm formation.
"By adding that hydroxyl group and making the 7-hydroxyindole, we turn off the bacterium's ability to talk. We short-circuit the bacterium, and it becomes less of a bad actor."
For more information, contact Source: Thomas K. Wood (979) 862-1588 thomas.wood(at)che.tamu.edu
-------------------- My biofilm film: www.whyamistillsick.com 2004 Mycoplasma Pneumonia 2006 Positive after 2 years of hell 2006-08 Marshall Protocol. Killed many bug species 2009 - Beating candida, doing better Lahey Clinic in Mass: what a racquet! Posts: 830 | From Mass. | Registered: Aug 2006
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northstar
Frequent Contributor (1K+ posts)
Member # 7911
posted
Cold Feet, That is a really interesting posting, and contains much beneficial information.
It is difficult , to impossible, to read with the second url so being so long that it stretches out all of the sentences in your post.
Would you help readers by editing that url using a tinyurl.com to shorten width?
Thank you, Northstar
Posts: 1331 | From hither and yonder | Registered: Sep 2005
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