Hoosiers51
Frequent Contributor (1K+ posts)
Member # 15759
posted
Hey everyone.
I forgot the name of this gene, but I remember testing positive for it.
Has anyone else with this gene had success treating your tick infections? I am hoping I am not screwed with this, so looking for success stories! Thanks!
Posts: 4590 | From Midwest | Registered: Jun 2008
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sparkle7
Frequent Contributor (5K+ posts)
Member # 10397
posted
Your genes are not written in stone. There's a field of science called epigenomics that has found that you can alter your genes.
posted
I have the DR2 (HLA-DRB1*1501) which - as they say - can make you therapy-refractory and can cause autoimmunity. I'm right now checking into this as I'm not very successful with abx.
Gabrielle
Posts: 767 | From Germany | Registered: Feb 2004
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posted
I have the "dreaded genotype"! I forget what the actual #s are.
It makes things tough, and I have had Lyme for 30+ years before diagnosis, but I can get into remission with the right treatment
-------------------- "We must be willing to get rid of the life we've planned, so as to have the life that is waiting for us" - e.m. forster Posts: 921 | From PA | Registered: Jan 2004
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adamm
Unregistered
posted
Wait--DR2 as well?!? Yikes! Would you mind posting some
The following subtypes have been described often in patients who didn't create any (or only weak) antibodies, despite of proven infection with Borrelia.
DR1-Allele (HLA-DRB1*0102, *0101, *0104, *0105)
Gabrielle
Posts: 767 | From Germany | Registered: Feb 2004
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sparkle7
Frequent Contributor (5K+ posts)
Member # 10397
Association of chronic Lyme arthritis with HLA-DR4 and HLA-DR2 alleles.
A C Steere, E Dwyer, R Winchester
BACKGROUND AND METHODS. A small percentage of patients infected with Borrelia burgdorferi have chronic Lyme arthritis that does not respond to antibiotic therapy.
To learn whether genetically determined variations in the host immune response might account for such outcomes, we determined the immunogenetic profiles of 130 patients with various manifestations of Lyme disease.
RESULTS. Of the 80 patients with arthritis, 57 percent of those with chronic arthritis (12 to 48 months in duration) had the HLA-DR4 specificity; only 23 percent of those with arthritis of moderate duration (6 to 11 months) and only 9 percent of those with arthritis of short duration (1 to 5 months) had this specificity (P = 0.003).
After the HLA-DR4-positive patients were excluded from each group, a secondary association was noted with HLA-DR2, which was found in 75 percent of the remaining patients with chronic arthritis and in 50 percent of those with arthritis of moderate duration, but in only 20 percent of those with arthritis of short duration (P = 0.023).
Altogether, 25 of the 28 patients with chronic arthritis (89 percent) had HLA-DR2 or HLA-DR4, or both, as compared with 27 percent of those with arthritis of short duration (relative risk, 22; P = 0.00006).
These HLA specificities appeared to act as independent, dominant markers of susceptibility. Nucleotide-sequence typing, performed in five patients with chronic arthritis, identified the HLA-DR2 allele as Dw2 (DR beta 1*1501), and the HLA-DR4 alleles as Dw4, Dw14, and Dw13 (DR beta 1*0401, DR beta 1*0404, and DR beta 1*0403, respectively).
The presence of HLA-DR4 in patients with arthritis was associated with a lack of response to antibiotic therapy (P = 0.01).
CONCLUSIONS. Particular Class II major histocompatibility genes determine a host immune response to B. burgdorferi that results in chronic arthritis and lack of response to antibiotic therapy.
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Note who the author is... and the date.
It's amazing how much research they have done on the topic of genetics & Lyme.
It just makes me wonder why it is so hard to get a proper diagnosis & treatment. They seem to be very good at diagnosing & analyzing Lyme in mice.
Look at how many studies have been done by clicking on the above link...
Posts: 7772 | From Northeast, again... | Registered: Oct 2006
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adamm
Unregistered
posted
Does anyone know how common each of the genotypes is?
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adamm
Unregistered
posted
Does anyone know how common each of the genotypes is?
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lpkayak
Honored Contributor (10K+ posts)
Member # 5230
posted
well i have hla-dr4 and my llmd yrs ago said that was a reason to stop abx (after 2-3 yrs aggressive orals)even tho i still had pain
i stopped , did a yr of detox and many symptoms went away...but not the pain
also i started traditional osteo arthrits tx...xrays showed no cartilage...
arthroscopy helped...but doc said will need knee replacemtns cuz no cartilage to work with
cosamine ds and ibuprofen kept me working for 10 yrs until a trauma totalled me out
i am recovering really well from knee replacements
i am off ibuprofen
i still take cosamine for hands and back
probably need hand surgery-but i'm going slow-getting over knees
pt will have to help back...no surgery
BUT...i do feel very clearly that abx help my other symptoms: cog, fatigue, neuro pain,
the doc didn't say i wouldn't respond to abx...but he did say if joint pain was the only symptom remaining, it was worth trying traditional arthritis tx: cosamine, nsaid, surgery, etc and going off abx for awhile
-------------------- Lyme? Its complicated. Educate yourself. Posts: 13712 | From new england | Registered: Feb 2004
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tailz
Unregistered
posted
Exposure to EMF/RF has been shown to alter DNA, so I no longer believe in genetics.
If diseases seem to run in families, it's only because, as a family, you all shared germs and common EMF/RF exposures for at least 18 years.
Likewise, if you're having trouble fighting Lyme, chances are you are still being overexposed, so in my opinion, moving to a low EMF/RF area is the 'cure', though I can't afford it myself.
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sparkle7
Frequent Contributor (5K+ posts)
Member # 10397
posted
I don't know adamm... it's pretty complex stuff.
I think alot more research has to be done in this field before they can say who has what & what it all means.
Meanwhile, there are many companies making money off of all this "genetic" testing...
Posts: 7772 | From Northeast, again... | Registered: Oct 2006
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Hoosiers51
Frequent Contributor (1K+ posts)
Member # 15759
posted
This is what Gabrielle said above that she has: DR2 (HLA-DRB1*1501)
and she said it was linked with autoimmunity.
For some reason, I want to say that might be the one I have, because joint pain is not a big issue for me, which is the one a lot of people mentioned here.
Also, autoimmune illness runs in my family.
Hmmmmm......thanks for all the replies though. Just things to think about.
And, you never know if people who share these genes have suggestions of certain things that helped them! Posts: 4590 | From Midwest | Registered: Jun 2008
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Hoosiers51
Frequent Contributor (1K+ posts)
Member # 15759
posted
PS---I used the fact that I have that gene as part of my case to get SS disability, along with a doc's brief description of what it means.....
so looks like the genetic testing companies aren't the only one's making money off the testing!
Posts: 4590 | From Midwest | Registered: Jun 2008
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