Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
"Increasing the CO2 levels in cultured rat liver cells led to an increase in the synthesis of glycogen from glucose."
Glycogen is then stored in fat...for emergency use...when we use those stores to produce glucose and...release amino acids. If "starving", we burn fat first then will use the proteins (amino acids) in muscle...as I understand it. That would make Bb happy...glucose and the amino acids to build its cell walls.
***Is this how Bb is gettin CH3 (methyl)?:***
Unlike other autotrophic pathways we've talked about,
the acetyl-CoA pathway of CO2-fixation is not a cycle.
* Involves the reduction of CO2 via two linear pathways.
**** One molecule of CO2 is reduced to form the methyl group and the other to form the carbonyl group.***
* A key enzyme is ***carbon monoxide dehydrogenase***, which
produces the CO
which ends up in the carbonyl position of the acetate.
* The methyl group of acetate originates from the reduction of CO2 by a series of reactions involving the coenzyme tetrahydrofolate.
* In the final step of the pathway, the ***CH3 group is combined with CO in CO dehydrogenase to form acetate***.
- Me: acetate?! As in sodium acetate?!!! YIKES.
* A Na+ motive force is established during acetogenesis which can be used to drive a Na+ -powered ATPase
1. We KNOW Bb is impacting the Na-Ca pump (looks to need Na!).
Now if someone is deficient in HO-1...you're not gonna believe what rescues the cells...
"Heme Oxygenase-1 Deficiency Accelerates Formation of Arterial Thrombosis Through Oxidative Damage to the Endothelium, Which Is
Rescued by Inhaled Carbon Monoxide
Heme oxygenase (HO)-1 (encoded by Hmox1) catalyzes the
oxidative degradation of heme to biliverdin and carbon monoxide."
and Fe = iron
"HO-1 is induced during inflammation and oxidative stress to protect tissues from oxidative damage."
On late night TV last night...genetic research re: *lowing insulin* to prolong life...and how all the bacteria communicate with one another!
In pancreatic cancer blocking insulin release was helpful.
This is curious:
"Researchers at Thomas Jefferson University in Philadelphia have discovered that an extract of nigella sativa seed oil, known as thymoquinone, can remedy one of the most virulent and difficult to treat cancers: pancreatic cancer.
The extract does this by blocking pancreatic cell growth, and actually enhancing the built-in cellular function that causes programmed cell death, or apoptosis."
Common Name Black seeds, Black cumin, fennel flower, black caraway, nutmeg flower, Roman coriander, black onion seed, kalonji
If you research the common names above, eventually you will find that they block insulin.
Insulin ACTIVATES PFK..."rate limiting enzyme for glycolysis". Bb is PFK "dependent".
"Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2."
MMP2 and MMP9 are upregulated. These bind to zinc (Bb has zinc fingers), but blocking those 2 metalproteinases (which trigger gelatinase and collagenase) may not be enough to destroy Bb.
MMP2 and MMP9 can be reduced by a number of OTC things and by minocycline (MMP9).
We need to back up...PGE-2 is upregulated.
COX-1 -> PGE1 -> HO-1
COX-2 (enter TNF alpha and IL1 B) -> PGE-2.
Blocking TNF alpha alone...(Humira) doesn't do the trick.
It looks like we have to trigger COX-1...because...
"Inhibition of In Vivo Insulin Secretion by Prostaglandin E1"
"expression of CD44 on pancreatic islet cells might be required to deliver a direct death sentence."
Beta cells are dying...Beta pancreatic cells produce insulin.
Looks like the body is trying to find a way.
Cancer cells have few mitochondria remaining, are dependent on "sugar", have DNA (***undermethylated***) damage...the list goes on.
Medical alternative possiblities:
To help your brain:
Lamictil...blocks Na channels and reduces glutamate (excitatory...up in lyme). It decreases folate. Given for manic-depression, seizures, etc. Watch for rash...can be deadly.
If pancreatic cancer...look at what "they" are trying to block: angiotensin II, VEGF (vascular endothelial growth factor), tyrosine kinase...nice try!
Watch your pancreatic enzyme levels! Pancreatitis can be a sign of cancer. (Sis-in-law...pancreatitis -> finding her breast cancer early).
Isn't this curious...Mn worsens tourettes (shakes)!
Bb uses Mn to replicate...
Makes me think about Parkinson's (shakes) too...
Onto some fun videos!
Posts: 9426 | From Sunshine State | Registered: Mar 2001
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
The Potbelly Syndrome: How Common Germs Cause Obesity, Diabetes, And Heart Disease (Paperback) - 2005
by Russell Farris (Author), Per Marin (Author)
8 customer reviews and you can look inside the book
about $13.00 -
Editorial Reviews
Product Description
Potbelly syndrome (PBS) is a metabolic disorder that affects about one-third of the adults in industrialized countries.
Its most important symptoms are abdominal obesity, high blood pressure, and type 2 diabetes.
Contrary to popular belief,these conditions are caused by chronic infections, not by bad habits. (Keebler's note: well, unless one DOES have bad habits.)
PBS is initiated by a small, long-term excess of the stress hormone cortisol.
The extra cortisol stimulates our appetite and slows down our metabolism. It makes fat accumulate in places where it isn't wanted or needed. Most of the fat settles around our waists, but some of it settles in our liver and muscles.
Liver and muscle cells aren't supposed to store fat, and the fat prevents them from working correctly.
As a result, we feel tired and hungry much of the time. As our potbellies grow and our PBS gets worse, our blood pressure, cholesterol, insulin, and blood sugar levels rise.
Most of the excess cortisol is produced in response to mild, chronic infections. Some of the germs that cause PBS also produce sores in our arteries. When these sores are large enough, they can block arteries and cause heart attacks.
"The Potbelly Syndrome" explains how to diagnose and treat some of the germs that cause PBS and heart disease. If you've done everything you were supposed to do and still gained weight, became diabetic, (or)
or had a heart attack,or if you are a medical professional who suspects that there are serious gaps in the current understanding of obesity, disbetes, and heart disease, "The Potbelly Syndrome" will provide you with the answers you need to bring about better health.
About the Author
Russell Farris is a retired artificial-intelligence researcher who spent most of his life solving problems for the U.S.
Navy. After suffering a heart attack in 1998, he began to apply his problem-solving skills to the study of heart disease and related illnesses.
Per Marin, M.D., Ph.,is a distinguished scientist, physician, and clinical teacher from Sweden.
He has been writing about obesity since 1985, and many of his eighty-two publications deal with the effects of cortisol on weight and health.
==
Yes, and I'm with Marine in that after we study, diversion, laugher is a good idea.
J Clin Laser Med Surg, 2003 Aug, 21 - 4, 231 - 5 A preliminary investigation into light-modulated replication of nanobacteria and heart disease; Sommer AP et al.;
OBJECTIVE: The purpose of this preliminary study is to evaluate the effect of various wavelengths of light on nanobacteria =NB . BACKGROUND
DATA: NB and mitochondria use light for biological processes .
NB have been described as multifunctional primordial nanovesicles with the potential to utilize solar energy for replication .
NB produce slime, a process common to living bacteria .
Slime release is an evolutionary important stress-dependent phenomenon increasing the survival chance of individual bacteria in a colony .
In the cardiovascular system, stress-induced bacterial colony formation may lead to a deposition of plaque .
METHODS: Cultured NB were irradiated with NASA-LEDs at different wavelengths of light: 670, 728 and 880 nm . Light intensities were about 500k Wm -2, and energy density was 1 x 10 - 4 J m -2 . RESULTS: Monochromatic light clearly affected replication of NB . Maximum replication was achieved at 670 nm .
CONCLUSIONS: The results indicate that suitable wavelengths of light could be instrumental in elevating the vitality level of NB,
***preventing the production of NB-mediated slime,***
and simultaneously ***increasing the vitality level of mitochondria .***
The finding could stimulate the design of cooperative therapy concepts that could reduce death caused by myocardial infarcts.''
Posts: 9426 | From Sunshine State | Registered: Mar 2001
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Hoosiers51
Frequent Contributor (1K+ posts)
Member # 15759
posted
Marnie, I have a question for you......
What is that about Lamictal you put at bottom of your first post? I totally didn't follow what you were saying because, well, it was way too advanced for me.
Basically, I was just randomly reading this thread, then saw something about Lamictal, which caught my eye because I have been on it for 3 years. Were you saying it's good? Why is that? (maybe dumb it down?)
I have had docs tell me to get off it because of the folate thing....they are like, "do you really need that? That will suck up your vitamin B and make you tired."
But I get really irritable when I go off it. Let's just say I am not a pleasant person without it. I was originally prescribed it for depression that didn't respond to any SSRIs, etc.
So, is it good for people with Lyme? Most of my Lyme/babs/bart symptoms are cognitive, along with horrible fatigue.
Also, I saw something about Na. I noticed taking salt pills makes me feel better. I would keep doing it, but everyone says too much salt if bad for you. UGH! Anyways, sorry so many questions........thanks!
Posts: 4590 | From Midwest | Registered: Jun 2008
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